Below you may find selected research articles from faculty in the School of Pharmacy.

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Submissions from 2011

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The Mechanosensory Role of Primary Cilia in Vascular Hypertension, Surya M. Nauli, Xingjian Jin, and Beerend P. Hierck

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Cumulative Clinical Experience from Over a Decade of Use of Levofloxacin in Community Acquired Pneumonia; Critical Appraisal and Role in Therapy, Ayman M. Noreddin, Walid F. Elkhatib, Kenji M. Cunnion, and George G. Zhanel

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Improved Inactivation Effect of Bacteria Fabrication of Mesoporous Anatase Films with Fine Ag Nanoparticles Prepared by Coaxial Vacuum Arc Deposition, Hamid Oveisi, Simin Rahighi, Xiangfen Jiang, Yoshiaki Agawa, Ali Beitollahi, Soichi Wakatsuki, and Yusuke Yamauchi

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3-Substitued Indoles: One Pot Synthesis and Evaluation of Anticancer and Src Kinase Inhibitory Activities, V. Kameshwara Rao, Bhupender S. Chhikara, Amir Nasrolahi Shirazi, Rakesh Tiwari, Keykavous Parang, and Anil Kumar

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Comparative Pharmacodynamics of Ceftobiprole, Daptomycin, Linezolid, Telavancin, Tigecycline, and Vancomycin in the Treatment of Methicillin Resistant Staphylococcus aureus: A Monte Carlo Simulation Analysis, Ahmed H. Salem, Ehab A. Noreddin, George G. Zhanel, and Ayman M. Noreddin

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Polyethylenimine-Conjugated Gold Nanoparticles: Gene Transfer Potential and Low Toxicity in the Cornea, Ajay Sharma, Ashish Tandon, Jonathan C. K. Tovey, Rangan Gupta, J. David Robertson, Jennifer A. Fortune, Alexander M. Klibanov, John W. Cowden, Frank G. Rieger, and Rajiv R. Mohan

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Thyroglobulin Gene Mutations in Congenital Hypothyroidism, Héctor M. Targovnik, Cintia E. Citterio, and Carolina M. Rivolta

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Co-Creation of Experiential Qualities, Vuk Uskoković

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Turning the Paradigm Upside Down: Postdocs as Principal Investigators’ Mentors, Vuk Uskoković

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Hydrolysis of Amelogenin by Matrix Metalloprotease-20 Accelerates Mineralization in vitro, Vuk Uskoković, Feroz Khan, Haichuan Liu, Halina Ewa Witkowska, Li Zhu, Wu Li, and Stefan Habelitz

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Biomimetic Precipitation of Uniaxially Grown Calcium Phosphate Crystals from Full-Length Human Amelogenin Sols, Vuk Uskoković, Wu Li, and Stefan Habelitz

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Dynamic Light Scattering and Zeta Potential of Colloidal Mixtures of Amelogenin and Hydroxyapatite in Calcium and Phosphate Rich Ionic Milieus, Vuk Uskoković, Roselyn Odsinada, Sonia Djordjevic, and Stefan Habelitz

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Extrapolating Strategies for the Scientific and Technological Development of Underdeveloped Societies from the Examples of South Korea, Slovenia and Serbia, Vuk Uskoković and Dragan Uskoković

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Antivirulence Potential of TR-700 and Clindamycin on Clinical Isolates of Staphylococcus aureus Producing Phenol-Soluble Modulins, Jason Yamaki, Timothy Synold, and Annie Wong-Beringer

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Ceftaroline Pharmacodynamic Activity versus Community-Associated and Healthcare-Associated Methicillin-Resistant Staphylococcus aureus, Heteroresistant Vancomycin-Intermediate S. aureus, Vancomycin-Intermediate S. aureus and Vancomycin-Resistant S. aureus Using an In Vitro Model, George G. Zhanel, Emma Rossnagel, Kim Nichol, Lauren Cox, James A. Karlowsky, Sheryl Zelenitsky, Ayman M. Noreddin, and Daryl J. Hoban

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Altered Self-Assembly and Apatite Binding of Amelogenin Induced by N-terminal Proline Mutation, Li Zhu, Vuk Uskoković, Thuan Le, Pamela DenBesten, Yulei Huang, Stefan Habelitz, and Wu Li

Submissions from 2010

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Synthesis, Antiviral and Contraceptive Activities of Nucleoside-Sodium Cellulose Sulfate Acetate and Succinate Conjugates, Hitesh K. Agarwal, Anil Kumar, Gustavo F. Doncel, and Keykavous Parang

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Synthesis of Nucleoside 5′-O-α,β-methylene-β-triphosphates and Evaluation of Their Potency Towards Inhibition of HIV-1 Reverse Transcriptase, Yousef Ahmadibeni, Chandravanu Dash, M. J. Hanley, S. F. J. Le Grice, Hitesh K. Agarwal, and Keykavous Parang

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5¢-O-b,g-Methylenetriphosphate Derivatives of Nucleoside, Yousef Ahmadibeni, Chandravanu Dash, S. F. J. Le Grice, and Keykavous Parang

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Isolation and Cultivation of Equine Corneal Keratocytes, Fibroblasts and Myofibroblasts, Dylan G. Buss, Elizabeth A. Giuliano, Ajay Sharma, and Rajiv R. Mohan

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Efficacy and Safety of Mitomycin C as an Agent to Treat Corneal Scarring in Horses Using an in vitro Model, Dylan G. Buss, Ajay Sharma, Elizabeth A. Giuliano, and Rajiv R. Mohan

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Gene Delivery in the Equine Cornea: A Novel Therapeutic Strategy, Dylan G. Buss, Ajay Sharma, Elizabeth A. Giuliano, and Rajiv R. Mohan

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Development of Cytarabine Prodrugs and Delivery Systems for Leukemia Treatment, Bhupender S. Chhikara and Keykavous Parang

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Intravenous Artesunate for Severe Malaria, Karl M. Hess, Jeffery A. Goad, and Paul M. Arguin

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Selective Binding of Linear Ubiquitin Chains to NEMO in NF-κB Activation, Fumiyo Ikeda, Simin Rahighi, Soichi Wakatsuki, and Ivan Dikic

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In Vitro Release of Indian Penny Wort, Walnut, and Turmeric from Topical Preparations Using Two Different Types of Membranes, Sonia Khiljee, Nisar Ur Rehman, Muhammad Khan Sarfaz, Hamidreza Montazeri Aliabadi, Tanzila Khiljee, and Raimar Löbenberg

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Fibroblast Specific Expression of AC6 Enhances ß-Adrenergic and Prostacyclin Signaling and Blunts Bleomycin-Induced Pulmonary Fibrosis, Xiaoqiu Liu, Shu Qiang Sun, Muthusamy Thangavel, Joseph Kaminsky, Joseph Kaminsky, Louisa Balazs, and Rennolds S. Ostrom

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A Participation Requirement to Engage Students in a Pharmacokinetics Course Synchronously Taught at a Local and Distant Campus, Reza Mehvar

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Vector Delivery Technique Affects Gene Transfer in the Cornea in vivo, Rajiv R. Mohan, Ajay Sharma, Tyler C. Cebulko, and Ashish Tandon

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Good Research Practices for Measuring Drug Costs in Cost-Effectiveness Analyses: Medicare, Medicaid and Other US Government Payers Perspectives: The ISPOR Drug Cost Task Force Report—Part IV, C. Daniel Mullins, Brian Seal, Enrique Seoane-Vazquez, Jayashri Sankaranarayanan, Carl V. Asche, Ravishankar Jayadevappa, Won Chan Lee, Dorothy K. Romanus, Junling Wang, Joel W. Hay, and Jim Smeeding

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A Comparative Study of Embedded and Anesthetized Zebrafish in Vivo on Myocardiac Calcium Oscillation and Heart Muscle Contraction, Brian S. Muntean, Christine M. Horvat, James H. Behler, Wissam A. AbouAlaiwi, Andromeda M. Nauli, Frederick E. Williams, and Surya M. Nauli

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Impaired M3 and Enhanced M2 Muscarinic Receptor Contractile Function in a Streptozotocin Model of Mouse Diabetic Urinary Bladder, K. J. Pak, Rennolds S. Ostrom, M. Matsui, and F. J. Ehlert

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The M2 Muscarinic Receptor Inhibits the Development of Streptozotocin-Induced Neuropathy of Mouse Urinary Bladder, K. J. Pak, Rennolds S. Ostrom, M. Matsui, and F. J. Ehlert

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Plasma Pharmacokinetics and Tissue Disposition of Novel Dextran- Methylprednisolone Conjugates with Peptide Linkers in Rats, Suman Penugonda, Hitesh K. Agarwal, Keykavous Parang, and Reza Mehvar

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Failure to ubiquitinate c-Met Leads to Hyperactivation of mTOR Signaling in a Mouse Model of Autosomal Dominant Polycystic Kidney Disease, Shan Qin, Mary Taglienti, Surya M. Nauli, Leah Contrino, Ayumi Takakura, Jing Zhou, and Jordan A. Kreidberg

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Hypertension in Autosomal Dominant Polycystic Kidney Disease: A Clinical and Basic Science Perspective, Shobha Ratnam and Surya M. Nauli

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Practice Patterns for Antibiotic De-escalation in Culture-Negative Healthcare-Associated Pneumonia, M. Schlueter, C. James, A. Dominguez, Laura V. Tsu, and G. Seymann

AAV Serotype Influences Gene Transfer in Corneal Stroma in vivo, Ajay Sharma

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Localization of Angiotensin Converting Enzyme in Rabbit Cornea and Its Role in Controlling Corneal Angiogenesis in vivo, Ajay Sharma, Daniel I. Bettis, John W. Cowden, and Rajiv R. Mohan

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"Transduction Efficiency of AAV 2/6, 2/8 and 2/9 Vectors for Delivering Genes in Human Corneal Fibroblasts ", Ajay Sharma, Arkasubhra Ghosh, Eric T. Hansen, Jason M. Newman, and Rajiv R. Mohan

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AAV Serotype Influences Gene Transfer in Corneal Stroma in vivo, Ajay Sharma, Jonathan C. K. Tovey, Arkasubhra Ghosh, and Rajiv R. Mohan

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Acute Depression of Energy Metabolism After Microdialysis Probe Implantation is Distinct from Ischemia-Induced Changes in Mouse Brain, Rachita K. Sumbria, Jochen Klein, and Ulrich Bickel

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Polystyrene-Supported Aluminum Chloride as an Efficient and Reusable Catalyst for Condensation of Indole with Various Carbonyl Compounds, Bahman Tamami, Amir Nasrolahi Shirazi, and Kaveh Parvanak Borujeni

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Role of Transforming Growth Factor Beta in Corneal Function, Biology and Pathology, Ashish Tandon, Jonathan C. K. Tovey, Ajay Sharma, Rangan Gupta, and Rajiv R. Mohan

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Synthesis and Evaluation of Conformationally Constrained Peptide Analogues as the Src SH3 Domain Binding Ligands, Rakesh Tiwari, Alex Brown, Seetha Narramaneni, Gongqin Sun, and Keykavous Parang

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HCMV pUS28 Initiates Pro-Migratory Signaling via Activation of Pyk2 Kinase, Jennifer Totonchy, Susan Varnum, Ryan Melnychuk, Patricia Smith, Ljiliana Pasa-Tolic, Janani I. Shutthanadan, and Daniel N. Streblow

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Major Challenges for the Modern Chemistry in Particular and Science in General, Vuk Uskoković

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Morphological Study of Emulsion-Assisted Cholesterol Precipitation Processes, Vuk Uskoković

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Prospects and Pits on the Path of Biomimetics: The Case of Tooth Enamel, Vuk Uskoković

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The Metaphorical Model: The Bridge between Science and Religion, Vuk Uskoković

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Nanotechnology in Dental Sciences: Moving Towards a Finer Way of Doing Dentistry, Vuk Uskoković and Luiz Eduardo Bertassoni

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Zeta-Potential and Particle Size Analysis of Recombinant Human Amelogenins, Vuk Uskoković; Z. Castiglione; P. Cubas; L. Zhu; W, Li; and S. Habelitz

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Strategies for the Scientific Progress of the Developing Countries in the New Millennium: The Case of Serbia in Comparison with Slovenia and South Korea, Vuk Uskoković, Milica Ševkušić, and Dragan P. Uskoković

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Nanosized Hydroxyapatite and Other Calcium Phosphates: Chemistry of Formation and Application as Drug and Gene Delivery Agents, Vuk Uskoković and Dragan Uskoković

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Disparity Implications of Medicare Eligibility Criteria for Medication Therapy Management Services, Junling Wang, C. Daniel Mullins, Lawrence M. Brown, Ya-Chen Tina Shih, Samuel Dagogo-Jack, Song Hee Hong, and William C. Cushman

Submissions from 2009

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Primary Cilia: Highly Sophisticated Biological Sensors, Wissam A. AbouAlaiwi, Shao T. Lo, and Surya M. Nauli

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Ciliary Polycystin-2 Is a Mechanosensitive Calcium Channel Involved in Nitric Oxide Signaling Cascades, Wissam A. AbouAlaiwi, Maki Takahashi, Blair Mell, Thomas J. Jones, Shobha Ratnam, Robert J. Kolb, and Surya M. Nauli

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Synthesis of Nucleoside Mono-, Di-, and Triphosphoramidates from Solid-Phase cyclo Saligenyl Phosphitylating Reagents, Yousef Ahmadibeni, Rakesh Tiwari, Gongqin Sun, and Keykavous Parang

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The Proteolytic Stability and Cytotoxicity Studies of l‐Aspartic Acid and l‐Diaminopropionic Acid derived β‐Peptides and a Mixed α/β‐Peptide, Sahar Ahmed and Kamaljit Kaur

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Rat Cytomegalovirus Infection Depletes MHC II in Bone Marrow Derived Dendritic Cells, Carmen C. Baca Jones, Craig N. Kreklywich, Ilhem Messaoudi, Jennifer Totonchy, Erin McCartney, Susan L. Orloff, Jay A. Nelson, and Daniel N. Streblow

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The First Total Synthesis of (±)-4-methoxydecanoic Acid: A Novel Antifungal Fatty Acid, Nestor Carballeira, Carlos Miranda, and Keykavous Parang

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Novel Approach Against Central Venous Catheter Associated Infection with Acinetobacter baumannii Biofilm, Walid Elkhatib and Ayman M. Noreddin

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The Guinea Pig Ileum Lacks the Direct, High-Potency, M2-Muscarinic, Contractile Mechanism of the Mouse Ileum, Michael T. Griffin, Minoru Matsui, Rennolds S. Ostrom, and Frederick J. Ehlert

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Isoniazid Completion Rates for Latent Tuberculosis Infection Among College Students Managed by a Community Pharmacist, Karl M. Hess, Jeffery A. Goad, Joanne Wu, and Kathleen Johnson

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Eugenia jambolana Lam. Berry Extract Inhibits Growth and Induces Apoptosis of Human Breast Cancer but Not Non-Tumorigenic Breast Cells, Liya Li, Lynn S. Adams, Caroline Killian, Aftab Ahmed, and Navindra P. Seeram

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Pharmacodynamic Target Attainment Potential of Azithromycin, Clarithromycin and Telithromycin in Serum and Epithelial Lining Fluid (ELF) of Community Acquired Pneumonia (CAP) Patients with Penicillin-Susceptible, Intermediate and Resistant Streptococcus pneumoniae, Ayman M. Noreddin, Walid El-Khatib, Jason Aolie, Ahmed H. Salem, and George G. Zhanel

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Updated Guidelines for Manuscripts Describing Instructional Design and Assessment: The IDEAS Format, Therese Poirier, Michael Crouch, George MacKinnon, Reza Mehvar, and Mary Monk-Tutor

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Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-κB Activation, Simin Rahighi, Fumiyo Ikeda, Masato Kawasaki, Masato Akutsu, Nobuhiro Suzuki, Ryuichi Kato, Tobias Kensche, Tamami Uejima, Stuart Bloor, David Komander, Felix Randow, Soichi Wakatsuki, and Ivan Dikic

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Provision of Health Care Services in Canada: Challenges and Opportunities, Rosa Rodriguez-Monguio, Enrique Seoane-Vazquez, and Fernando Antoñanzas Villar

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Trichostatin A Inhibits Corneal Haze in vitro and in vivo, Ajay Sharma, Maneesh M. Mehan, Sunilima Sinha, John W. Cowden, and Rajiv R. Mohan

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Localization and Coupling of Adenylyl Cyclase Isoforms 2, 3 and 6 With G Protein-Coupled Receptors in Mouse Bronchial Smooth Muscle Cells, Muthusamy Thangavel, Piyatilake Adris, and Rennolds S. Ostrom

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The C1 and C2 Domains Target Human Type 6 Adenylyl Cyclase to Lipid Rafts and Caveolae, Muthusamy Thangavel, Xiaoqiu Liu, Shu Qiang Sun, Joseph Kaminsky, and Rennolds S. Ostrom

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Differential Ligand Binding to a Human Cytomegalovirus Chemokine Receptor Determines Cell Type-Specific Motility, Jennifer Totonchy, Ryan Melnychuk, Patricia P. Smith, Joshua Powell, Laurel Hall, Victor R. DeFilippis, Klaus Fruh, Martine Smit, David D. Schlaepfer, Jay A. Nelson, and Daniel N. Streblow

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Human Cytomegalovirus US28: A Functionally Selective Chemokine Binding Receptor, Jennifer Totonchy, Jay A. Nelson, and Daniel N. Streblow

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A Collection of Micrographs: Where Science and Art Meet, Vuk Uskoković

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Challenges for the Modern Science in its Descend Towards Nano Scale, Vuk Uskoković

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New Dosing Schedules of Dasatinib for CML and Adverse Event Management, Siu Fun Wong

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CD82 Endocytosis Reveals Cholesterol-Dependent Reorganization of Tetraspanin-Enriched Microdomains and Lipid Rafts, Congfeng Xu, Yanhui H. Zhang, Muthusamy Thangavel, Mekel M. Richardson, Lu Liu, Bin Zhou, Yi Zheng, Rennolds S. Ostrom, and Xin A. Zhang

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The Complete Genome of Teredinibacter turnerae T7901: An Intracellular Endosymbiont of Marine Wood-Boring Bivalves (Shipworms), Joyce C. Yang, Ramana Madapu, A. Scott Durkin, Nathan A. Ekborg, Chandra S. Pedamallu, Jessica B. Hostetler, Diana Radune, Bradley S. Toms, Bernard Henrissat, Pedro M. Coutinho, Sandra Schwarz, Lauren Field, Amaro E. Trindade-Silva, Carlos A. G. Soares, Sherif Elshahawi, Amro Hanora, Eric W. Schmidt, Martha G. Haygood, Joanos Posfai, Jack Benner, Catherine Madinger, John Nove, Brian Anton, Kshitiz Chaudhary, Jeremy Foster, Alex Holman, Sanjay Kumar, Philip A. Lessard, Yvette A. Luyten, Barton Slatko, Nicole Wood, Bo Wu, Max Teplitski, Joseph D. Mougous, Naomi Ward, Jonathan A. Eisen, Jonathan H. Badger, and Daniel L. Distel

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Synthesis and Evaluation of Phosphopeptides Containing Iminodiacetate Groups as Binding Ligands of the Src SH2 Domain, Guofeng Ye, Aaron D. Schuler, Yousef Ahmadibeni, Joel R. Morgan, Absar Faruqui, Kezhen Huang, Gongqin Sun, John A. Zebala, and Keykavous Parang

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Pharmacodynamic Activity of Ceftobiprole Compared with Vancomycin versus Methicillin-Resistant Staphylococcus aureus (MRSA), Vancomycin-Intermediate Staphylococcus aureus (VISA) and Vancomycin-Resistant Staphylococcus aureus (VRSA) Using an In Vitro Model, George G. Zhanel, Dylan Voth, Kim Nichol, James A. Karlowsky, Ayman M. Noreddin, and Daryl J. Hoban

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Liquid Chromatography-Tandem Mass Spectrometry for the Determination of Methylprednisolone in Rat Plasma and Liver After Intravenous Administration of Its Liver-Targeted Dextran Prodrug, Shuang-Qing Zhang, Helen R. Thorsheim, Suman Penugonda, Venkateswaran C. Pillai, Quentin R. Smith, and Reza Mehvar

Submissions from 2008

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Symmetrical Dinucleosides, Yousef Ahmadibeni and Keykavous Parang

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Helical Peptides Derived from Lactoferrin Bind Hepatitis C Virus Envelope Protein E2, Reem Beleid, Donna Douglas, Norman Kneteman, and Kamaljit Kaur

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Zoledronic Acid Markedly Improves Bone Mineral Density for Patients with Monoclonal Gammopathy of Undetermined Significance and Bone Loss, James R. Berenson, Ori Yellin, Ralph V. Boccia, Marshall Flam, Siu Fun Wong, Olcay Batuman, Mehdi M. Moezi, Donald Woytowitz, Herbert Duvivier, Youram Nassir, and Regina A. Swift

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A High-Throughput In Vitro Model Illustrating Potential Microbiologocal Interactions During Treatment of Pseudomonas aeroginosa Biofilm Associated Infections, Walid Elkhatib, Virginia Haynes, and Ayman M. Noreddin

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Right-handed 14-Helix in β3-Peptides from L-Aspartic Acid Monomers, Kamaljit Kaur, Tara Sprules, Wael Soliman, Reem Beleid, and Sahar Ahmed

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Ciliary Dysfunction in Polycystic Kidney Disease: An Emerging Model with Polarizing Potential, Robert J. Kolb and Surya M. Nauli

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Fibroblast-Specific Expression of Adenylyl Cyclase 6 Reduces Myofibroblast Differentiation and Protects Against Bleomycin-Induced Pulmonary Fibrosis, Xiaoqiu Liu, Fengying Li, and Rennolds S. Ostrom

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Adenylyl Cyclase Type 6 Overexpression Selectively Enhances ß-Adrenergic and Prostacyclin Receptor Mediated Inhibition of Rat Cardiac Fibroblast Function Due to Co-Localization in Lipid Rafts, Xiaoqiu Liu, Muthusamy Thangavel, Shu Qiang Sun, Joseph Kaminsky, Penden Mahautmr, Jeremiah Stitham, John Hwa, and Rennolds S. Ostrom

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Endothelial Cilia Are Fluid Shear Sensors That Regulate Calcium Signaling and Nitric Oxide Production Through Polycystin-1, Surya M. Nauli, Yoshifumi Kawanabe, John J. Kaminski, William J. Pearce, Donald E. Ingber, and Jing Zhou

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An Orphan GCPR Finds a Home in the Heart. Focus On “Myocardial Expression, Signaling and Function of GPR22; a Protective Role for an Orphan G Protein-Coupled Receptor”, Hemal H. Patel and Rennolds S. Ostrom

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Synthesis and In Vitro Characterization of Novel Dextran- Methylprednisolone Conjugates with Peptide Linkers: Effects of Linker Length on Hydrolytic and Enzymatic Release of Methylprednisolone and Its Peptidyl Intermediates, Suman Penugonda, Anil Kumar, Hitesh K. Agarwal, Keykavous Parang, and Reza Mehvar

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Assessing the Efficiency of Hospital Pharmacy Services in Thai Public District Hospitals, Thananan Rattanachotphanit, Chulaporn Limwattananon, Supon Limwattananon, Jeff R. Johns, Jon C. Schommer, and Lawrence M. Brown

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Work Profiles Identified from the 2007 Pharmacist and Pharmaceutical Scientist Career Pathway Profile Survey, Jon C. Schommer, Lawrence M. Brown, and Elliott M. Sogol

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Drug Selection and Adverse Drug Reactions: Balancing Outcomes and Costs, Enrique Seoane-Vazquez

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Incentives for Orphan Drug Research and Development in the United States, Enrique Seoane-Vazquez, Rosa Rodriguez-Monguio, Sheryl L. Szeinbach, and Jay Visaria

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Proteomic Analysis Detects Cytoskeletal-Related Proteins That Interact With the Intracellular C1 Domain of Adenylyl Cyclase 6, Muthusamy Thangavel, Xiaoqiu Liu, and Rennolds S. Ostrom

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Composites Comprising Cholesterol and Carboxymethyl Cellulose, Vuk Uskoković

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Insights into Morphological Nature of Precipitation of Cholesterol, Vuk Uskoković