Below you may find selected research articles from faculty in the School of Pharmacy.

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Submissions from 2008

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Nanomaterials and Nanotechnologies: Approaching the Crest of this Big Wave, Vuk Uskoković

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Surface Charge Effects Involved in the Control of Stability of Sols Comprising Uniform Cholesterol Particles, Vuk Uskoković

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Enzymatic Processing of Amelogenin during Continuous Crystallization of Apatite, Vuk Uskoković, M.-K. Kim, W. Li, and S. Habelitz

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PDGF-Driven Proliferation, Migration, and IL8 Chemokine Secretion in Human Corneal Fibroblasts Involve JAK2-STAT3 Signaling Pathway, Neeraj Vij, Ajay Sharma, Mahesh Thakkar, Sunilima Sinha, and Rajiv R. Mohan

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Apurinic/Apyrimidinic Endonuclease/Redox Effector Factor-1(APE/Ref-1): A Unique Target for the Prevention and Treatment of Human Melanoma, Sun Yang and Frank L. Meyskens

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Nitric Oxide Initiates Progression of Human Melanoma via a Feedback Loop Mediated by Apurinic/Apyrimidinic Endonuclease-1/redox Factor-1, Which is Inhibited by Resveratrol, Zhen Yang, Sun Yang, Bobbye J. Misner, Rita Chiu, Feng Liu, and Frank L. Meyskens Jr.

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Pharmacodynamic Activity of Ertapenem versus Multidrug-Resistant Genotypically Characterized Extended-Spectrum Beta-Lactamase-Producing Escherichia coli Using an In Vitro Model, George G. Zhanel, Patricia Baudry, Vibhu Vashisht, Nancy Laing, Ayman M. Noreddin, and Daryl J. Hoban

Submissions from 2007

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Protein Pyrophosphorylation by Inositol Pyrophosphates is a Posttranslational Event, Rashna Bhandari, Adolfo Saiardi, Yousef Ahmadibeni, Adele M. Snowman, Adam C. Resnick, Troels Z. Kristiansen, Henrik Molina, Akhilesh Pandey, J. Kent Werner Jr., Krishna R. Juluri, Yong Xu, Glenn D. Prestwich, Keykavous Parang, and Solomon H. Snyder

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Synthesis And Antifungal Properties Of Alpha-Methoxy And Alpha-Hydroxyl Substituted 4-Thiatetradecanoic Acids, Nestor Carballeira, Rosann O'Neill, and Keykavous Parang

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Effects of Methylprednisolone and Its Liver-Targeted Dextran Prodrug on Ischemia–Reperfusion Injury in a Rat Liver Transplantation Model, Anjaneya Chimalakonda and Reza Mehvar

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Antagonism of p66shc by Melanoma Inhibitory Activity, K. Kasuno, A. Naqvi, J. DeRicco, T. Yamamori, L. Santhanam, I. Mattagajasingh, Sun Yang, F. L. Meyskens, A.-K. Bosserhoff, and K. Irani

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Improving Medication Safety in the ICU: The Pharmacist’s Role, Audrey J. Lee, Teresa B. Chiao, Jerika T. Lam, Shamima Khan, and Maureen S. Boro

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Expression and Localization of Adenylyl Cyclases and G Protein Receptors in Guinea Pig Ileum Caveolae and Lipid Rafts, Richard Reece, Xiaoqiu Liu, Shu Q. Sun, Frederick J. Ehlert, and Rennolds S. Ostrom

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The Proximal Segments of the Cytosolic Domain of Adenylyl Cyclase Type 6 Localize to Plasma Membrane Lipid Rafts and Caveolae, Muthusamy Thangavel, Xiaoqiu Liu, and Rennolds S. Ostrom

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Four Novel Co-Precipitation Procedures for the Synthesis of Lanthanum-Strontium Manganites, Vuk Uskoković and Miha Drofenik

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Uniform Particles of Pure and Silica Coated Cholesterol, Vuk Uskoković and Egon Matijević

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Drug Utilization and Cost in a Medicaid Population: A Simulation Study of Community vs. Mail Order Pharmacy, Satish Valluri, Enrique Seoane-Vazquez, Rosa Rodriguez-Monguio, and Sheryl L. Szeinbach

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Fibrocystin/Polyductin, Found in the Same Protein Complex with Polycystin-2, Regulates Calcium Responses in Kidney Epithelia, Shizuan Wang, Jingjing Zhang, Surya M. Nauli, Xiaogang Li, Patrick G. Starremans, Ying Luo, Kristina A. Roberts, and Jing Zhou

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Redox Effector Factor-1, Combined with Reactive Oxygen Species, Plays an Important Role in the Transformation of JB6 Cells, Sun Yang, Bobbye J. Misner, Rita J. Chiu, and Frank L. Meyskens Jr.

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Common and Distinct Mechanisms of Different Redox-Active Carcinogens Involved in the Transformation of Mouse JB6P+ Cells, Sun Yang, Bobbye J. Misner, Rita Chiu, and Frank L. Meyskens Jr.

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Synthesis and Evaluation of Tripodal Peptide Analogues for Cellular Delivery of Phosphopeptides, Guofeng Ye, Nguyen Hai Nam, Anil Kumar, Ali Saleh, Dinesh B. Shenoy, Mansoor M. Amiji, Xiaofeng Lin, Gongqin Sun, and Keykavous Parang

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Pharmacodynamic Activity of Ertapenem versus Penicillin-Susceptible and Penicillin-Non-Susceptible Streptococcus pneumoniae Using an In Vitro Model, George G. Zhanel, Sheldon Derkatch, Nancy Laing, Ayman M. Noreddin, and Daryl J. Hoban

Submissions from 2006

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The Science of Prevention Strategies, Rachel Abrishami and Jeffery A. Goad

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2,6-Hexadecadiynoic Acid and 2,6-Nonadecadiynoic Acid - Novel Synthesized Acetylenic Fatty Acids as Potent Antifungal Agents, Nestor Carballeira, David Sanabria, Clarisa Cruz, Keykavous Parang, Baojie Wan, and Scott Franzblau

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Attenuation of Acute Rejection in a Rat Liver Transplantation Model by a Liver-Targeted Dextran Prodrug of Methylprednisolone, Anjaneya Chimalakonda, Donald L. Montgomery, Jon A. Weidanz, Imam H. Shaik, Justin H. Nguyen, John J. Lemasters, Eiji Kobayashi, and Reza Mehvar

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Immunization Update, Karl M. Hess and Jeffery A. Goad

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Synthesis of Polymer-Bound 4-acetoxy-3-phenylbenzaldehyde Derivatives: Applications in Solid-Phase Organic Synthesis, Anil Kumar, Guofeng Ye, Yousef Ahmadibeni, and Keykavous Parang

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Synthesis and Structure-Activity Relationships of Linear and Conformationally Constrained Peptide Analogues of CIYKYY as Src Tyrosine Kinase Inhibitors, Anil Kumar, Guofeng Ye, Yuehao Wang, Xiaofeng Lin, Gongqin Sun, and Keykavous Parang

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Cost Prevention of HIV, Jerika Lam

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cAMP Inhibits TGF-ß-Stimulated Collagen Synthesis via Inhibition of ERK1/2 and SMAD Signaling in Rat Cardiac Fibroblasts, Xiaoqiu Liu, Shu Qiang Sun, Avi Hassid, and Rennolds S. Ostrom

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Palmitoylation at Cys 1145 in the Carboxyl Terminus of Human Type 6 Adenylyl Cyclase is Not Required for Targeting to Lipid Rafts and Caveolae, Xiaoqiu Liu, Shu Qiang Sun, and Rennolds S. Ostrom

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TGFß Signaling via ERK1/2 and Smad is Inhibited by cAMP-Elevating Agents in Rat Cardiac Fibroblasts, Xiaoqiu Liu, Shu Qiang Sun, and Rennolds S. Ostrom

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Estimation of Pharmacokinetic Parameters Based on the Patient-Adjusted Population Data, Reza Mehvar

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Interdependency of Pharmacokinetic Parameters: A Chicken-and-Egg Problem? Not!, Reza Mehvar

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Insights into the Effects of Hyperlipoproteinemia on Cyclosporine A Biodistribution and Relationship to Renal Function, Hamidreza Montazeri Aliabadi, Tara J. Spencer, Parvin Mahdipoor, Afsaneh Lavasanifar, and Dion R. Brocks

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Loss of Polycystin-1 in Human Cyst-Lining Epithelia Leads to Ciliary Dysfunction, Surya M. Nauli, Sandro Rossetti, Robert J. Kolb, Francis J. Alenghat, Mark B. Consugar, Peter C. Harris, Donald E. Ingber, Mahmoud Loghman-Adham, and Jing Zhou

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Stromal Haze, Myofibroblasts, and Surface Irregularity after PRK, Marcelo V. Netto, Rajiv R. Mohan, Sunilima Sinha, Ajay Sharma, William Dupps, and Steven E. Wilson

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Effect of Prophylactic and Therapeutic Mitomycin C on Corneal Apoptosis, Cellular Proliferation, Haze, and Long-Term Keratocyte Density in Rabbits, Marcelo V. Netto, Rajiv R. Mohan, Sunilima Sinha, Ajay Sharma, Pankaj C. Gupta, and Steven E. Wilson

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Caveolin-2, Rennolds S. Ostrom

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Methods for the Study of Signaling Molecules in Membrane Lipid Rafts and Caveolae, Rennolds S. Ostrom and Paul A. Insel

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Rapid Determination of Reduced and Oxidized Glutathione Levels Using a New Thiol-Masking Reagent and the Enzymatic Recycling Method: Application to the Rat Liver and Bile Samples, Imam H. Shaik and Reza Mehvar

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Mechanism of a Solid-State Formation of La1-xSrxMnO3+δ (0 < x < 0.5) and Magnetic Characterization Thereof, Vuk Uskoković and Miha Drofenik

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Synthesis of Lanthanum-Strontium Manganites by Oxalate-Precursor Co-Precipitation Methods in Solution and in Reverse Micellar Microemulsion, Vuk Uskoković and Miha Drofenik

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Preparation of Silica-Coated Lanthanum-Strontium Manganite Particles with Designable Curie Point, for Application in Hyperthermia Treatments, Vuk Uskoković, Aljoša Košak, and Miha Drofenik

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Silica-Coated Lanthanum-Strontium Manganites for Hyperthermia Treatments, Vuk Uskoković, Aljoša Košak, and Miha Drofenik

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Selective Effects of Nitric Oxide on the Disposition of Chlorzoxazone and Dextromethorphan in Isolated Perfused Rat Livers, Ragini Vuppugalla and Reza Mehvar

Submissions from 2005

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Fibrotic Lung Fibroblasts Show Blunted Inhibition by cAMP Due to Deficient cAMP Response Element-Binding Protein Phosphorylation, Xiaoqiu Liu, Shu Qiang Sun, and Rennolds S. Ostrom

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Redox Regulation by Intrinsic Species and Extrinsic Nutrients in Normal and Cancer Cells, Archana Jaiswal McEligot, Sun Yang, and Frank L. Meyskens Jr.

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Role of Protein Binding in Pharmacokinetics, Reza Mehvar

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Mouse Cytomegalovirus M33 is Necessary and Sufficient in Virus-Induced Vascular Smooth Muscle Cell Migration, Ryan Melnychuk, Patsy Smith, Craig N. Kreklywich, Franziska Ruchti, Jennifer Totonchy, Laurel Hall, Lambert Loh, Jay A. Nelson, Susan L. Orloff, and Daniel N. Streblow

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Chronic Hypoxia Modulates Relations Among Calcium, Myosin Light Chain Phosphorylation, and Force Differently in Fetal and Adult Ovine Basilar Arteries, Surya M. Nauli, James M. Williams, William T. Gerthoffer, and William J. Pearce

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Caveolins Muscle Their Way Into the Regulation of Cell Differentiation, Development and Function. Focus On “Muscle-Specific Interaction of Caveolin Isoforms (Cav-1, Cav-2 and Cav-3): Differential Complex Formation Between Caveolins in Fibroblastic Versus Muscle Cells", Rennolds S. Ostrom

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A Mechanism for the Formation of Nanostructured NiZn Ferrites via a Microemulsion-Assisted Precipitation Method, Vuk Uskoković and Miha Drofenik

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Synthesis of Relatively Highly Magnetic Nano-Sized NiZn-Ferrite in Microemulsion at 45 oC, Vuk Uskoković and Miha Drofenik

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Synthesis of Lanthanum-Strontium Magnanites by a Hydroxide-Precursor Co-Precipitation Method in Solution and in Reverse Micellar Microemulsion, Vuk Uskoković, Darko Makovec, and Miha Drofenik

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Enzyme-Selective Effects of Nitric Oxide on Affinity and Maximum Velocity of Various Rat Cytochromes P450, Ragini Vuppugalla and Reza Mehvar

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Alterations in the Expression of the Apurinic/Apyrimidinic Endonuclease-1/redox Factor-1 (APE/Ref-1) in Human Melanoma and Identification of the Therapeutic Potential of Resveratrol as an APE/Ref-1 Inhibitor, Sun Yang, Kaikobad Irani, Susan E. Heffron, Frances Jurnak, and Frank L. Meyskens Jr.

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Alterations in Activating Protein 1 Composition Correlate with Phenotypic Differentiation Changes Induced by Resveratrol in Human Melanoma, Sun Yang and Frank L. Meyskens Jr.

Submissions from 2004

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Gating of the Polycystin Ion Channel Signaling Complex in Neurons and Kidney Cells, Patrick Delmas, Surya M. Nauli, Xiaogang Li, Bertrand Coste, Nancy Osorio, Marcel Crest, David A. Brown, and Jing Zhou

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Inhibitors of Protein Kinase Signaling Pathways Emerging Therapies for Cardiovascular Disease, Thomas Force, Keisuke Kuida, Mark Namchuk, Keykavous Parang, and John M. Kyriakis

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Cyclic AMP-Elevating Agents and Adenylyl Cyclase Overexpression Promote an Anti-Fibrotic Phenotype in Pulmonary Fibroblasts, Xiaoqiu Liu, Rennolds S. Ostrom, and Paul A. Insel

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Non-prescription and Household Substances of Abuse, J. Mallari, L. Nguyen, and Jeffery A. Goad

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The Relationship Among Pharmacokinetic Parameters: Effects of Altered Kinetics on the Drug Plasma Concentration-Time Profiles, Reza Mehvar

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Hepatic Disposition of Cyclosporine A in Isolated Perfused Rat Livers, Reza Mehvar and Anjaneya Chimalakonda

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Nitric Oxide Inhibition of Adenylyl Cyclase Type 6 Activity is Dependent upon Lipid Rafts and Caveolin Signaling Complexes, Rennolds S. Ostrom, Richard A. Bundey, and Paul A. Insel

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The Evolving Role of Lipid Rafts and Caveolae in G Protein-Coupled Receptor Signaling: Implications for Molecular Pharmacology, Rennolds S. Ostrom and Paul A. Insel

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Guidelines for Manuscripts Describing Instructional Design or Assessment: The IDEAS Format, Therese Poirier, Michael Crouch, Emily Hak, George MacKinnon, Reza Mehvar, and Mary Monk-Tutor

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Hepatitis B Vaccination for Patients with Chronic Renal Failure, Robert J. Schroth, Carol A. Hitchon, Julia Uhanova, Ayman M. Noreddin, Shayne P. Taback, Michael Moffatt, and James M. Zacharias

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Designing Fluoroquinolone Breakpoints for Streptococcus pneumoniae Using Genetics instead of Pharmacokinetics/Pharmacodynamics, H. J. Smith, Ayman M. Noreddin, C. G. Siemens, K. N. Schurek, J. Greisman, C. J. Hoban, D. J. Hoban, and G. G. Zhanel

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Synthesis of Nanocrystalline Nickel-Zinc Ferrites via a Microemulsion Route, Vuk Uskoković and Miha Drofenik

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The Characterization of Nanosized Nickel-Zinc Ferrites Synthesized within Reverse Micelles of CTAB/1-Hexanol/Water Microemulsion, Vuk Uskoković, Miha Drofenik, and Irena Ban

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Hepatic Disposition and Effects of Nitric Oxide Donors: Rapid and Concentration-Dependent Reduction in the Cytochrome P450-Mediated Drug Metabolism in Isolated Perfused Rat Livers, Ragini Vuppugalla and Reza Mehvar

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Short-Term Inhibitory Effects of Nitric Oxide on Cytochrome P450-mediated Drug Metabolism: Time Dependency and Reversibility Profiles in Isolated Perfused Rat Livers, Ragini Vuppugalla and Reza Mehvar

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Impaired Ca2+ Store Functions in Skeletal and Cardiac Muscle Cells from Sarcalumenin-Deficient Mice, Morikatsu Yoshida, Susumu Minamisawa, Miei Shimura, Shinji Komazaki, Hideaki Kume, Miao Zhang, Kiyoyuki Matsumura, Miyuki Nishi, Minori Saito, Yasutake Saeki, Yoshihiro Ishikawa, Teruyuki Yanagisawa, and Hiroshi Takeshima

Submissions from 2003

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A New Era in Pharmacy School Education, Lawrence M. Brown

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Hemorrhagic Fever Viruses, Jeffery A. Goad and J Nguyen

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Quality Assessment of a Collaborative Approach for Decreasing Drug-Related Morbidity and Achieving Therapeutic Goals, Brian J. Issetts, Lawrence M. Brown, Stephen W. Schondelmeyer, and Lois A. Lenarz

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Determination of the Substrate-Docking Site of Protein Tyrosine Kinase C-terminal Src Kinase, Sungsoo Lee, Xiaofeng Lin, Nguyen Hai Nam, Keykavous Parang, and Gongqin Sun

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Immortalized Epithelial Cells from Human Autosomal Dominant Polycystic Kidney Cysts, Mahmoud Loghman-Adham, Surya M. Nauli, Carlos E. Soto, Barbara Kariuki, and Jing Zhou

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Hypertonic Stress Co-Stimulates T Cell Il-2 Expression Through a Feedback Mechanism Involving ATP Release and P2 Receptor Activation of P38 Map Kinase, William H. Loomis, Sachiko Namiki, Rennolds S. Ostrom, Paul A. Insel, and Wolfgang G. Junger

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Angiotensin II Enhances Adenylyl Cyclase Signaling via Ca2+/Calmodulin. Gq-Gs Cross-Talk Regulates Collagen Production in Cardiac Fibroblasts, Rennolds S. Ostrom, Jennifer E. Naugle, Miki Hase, Caroline Gregorian, James S. Swaney, Paul A. Insel, Laurence L. Brunton, and J. Gary Meszaros

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Career Pathways Evaluation Program: 2002 Pharmacist Profile Survey, Jon C. Schommer, Lawrence M. Brown, Marsha K. Millonig, and Elliott M. Sogol

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Career Pathways for Pharmacists, Jon C. Schommer, Elliott M. Sogol, and Lawrence M. Brown

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Price of Pharmaceuticals, Value, R&D, and Intergenerational Equity, Enrique Seoane-Vazquez

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Human Cytomegalovirus Chemokine Receptor US28-Induced Smooth Muscle Cell Migration is Mediated by Focal Adhesion Kinase and Src, Daniel N. Streblow, Jennifer Totonchy, Patsy Smith, Ryan Melnychuk, Laurel Hall, Dora Pancheva, Martine Smit, Paola Casarosa, David D. Schlaepfer, and Jay A. Nelson

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Synthesis of Nanocrystalline Nickel-Zinc Ferrites within Reverse Micelles, Vuk Uskoković and Miha Drofenik

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Pharmacodynamic Activity of Azithromycin Against Macrolide-Susceptible and Macrolide-Resistant Streptococcus pneumoniae Simulating Clinically Achievable Free Serum, Epithelial Lining Fluid and Middle Ear Fluid Concentrations, George G. Zhanel, Mel DeCorby, Ayman M. Noreddin, Chris Mendoza, Andrew Cumming, Kim Nichol, Aleksandra Wierzbowski, and Daryl J. Hoban

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Antibiotic Activity Against Urinary Tract Infection (UTI) Isolates of Vancomycin-Resistant Enterococci (VRE): Results from the 2002 North American Vancomycin Resistant Enterococci Susceptibility Study (NAVRESS), George G. Zhanel, Nancy Laing, Kim Nichol, Lorraine P. Palatnick, Ayman M. Noreddin, Tamiko Hisanaga, Jack L. Johnson, NAVRESS Group, and Daryl J. Hoban

Submissions from 2002

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Outcome Assessment in a PharmD Program: The Texas Tech Experience, Reza Mehvar and Robert B. Supernaw

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Pharmacodynamic Modeling of Clarithromycin Against Macrolide-Resistant (PCR positive mefA or ermB) Streptococcus pneumoniae Simulating Clinically Achievable Free Drug Serum and Epithelial Lining Fluid Concentrations, Ayman M. Noreddin, Danielle Roberts, Kim Nichol, Aleksandra Wierzbowski, Daryl J. Hoban, and George G. Zhanel

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New Determinants of Receptor-Effector Coupling: Trafficking and Compartmentation in Membrane Microdomains, Rennolds S. Ostrom

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Localization of Adenylyl Cyclase Isoforms and G Protein-Coupled Receptors in Vascular Smooth Muscle Cells: Expression in Caveolin-Rich and Non-Caveolin Domains, Rennolds S. Ostrom, Xiaoqiu Liu, Brian P. Head, Caroline Gregorian, Tammy M. Seasholtz, and Paul A. Insel

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Mechanisms of cGMP-Induced Cerebral Vasodilatation: Contractile Agonist and Developmental Age Make a Difference, William J. Pierce and Surya M. Nauli

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Distribution of Functional P2X1-like Receptor in Isolated Rabbit Arteries, Lei-Ming Ren and Miao Zhang

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Polymerase Chain Reaction: An Emerging Tool for Research in Pharmacology, Rishi Sharma, Manjeet Singh, and Ajay Sharma

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The 2001 National Pharmacy Consumer Survey, Andy Stergachis, Lucinda L. Maine, and Lawrence M. Brown

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Methodology for the Assessment of Competence and the Definition of Deficiencies of Students in All Levels of the Curriculum, Robert B. Supernaw and Reza Mehvar

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Synthesis and Characterization of Hydroxyapatite-Collagen Biocomposite Materials, Vuk Uskoković, Nenad Ignjatović, and Nadejda Petranović

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Pharmacodynamic Activity of Fluoroquinolones Against Ciprofloxacin-Resistant Streptococcus pneumoniae, George G. Zhanel, Danielle Roberts, Andrew Waltky, Nancy Laing, Kim Nichol, Heather Smith, Ayman M. Noreddin, Tracy Bellyou, and Daryl J. Hoban

Submissions from 2001

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Principles of Nonlinear Pharmacokinetics, Reza Mehvar