Below you may find selected research articles from faculty in the School of Pharmacy.

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Submissions from 2012

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One-Pot Regioselective Synthesis of Tetrahydroindazolones and Evaluation of Their Anti-proliferative and Src Kinase Inhibitory Activities, V. Kameshwara Rao, Bhupender S. Chhikara, Rakesh Tiwari, Amir Nasrolahi Shirazi, Keykavous Parang, and Anil Kumar

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Medication Therapy Management, Challenges: The Pharmacist’s Emerging Role, Parth D. Shah, Jeffery A. Goad, Edith Mirzaian, and Melissa Durham

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Hepatic Immunosuppressive Effects of Systemically- Administered Novel Dextran-Methylprednisolone Prodrugs with Peptide Linkers in Rats, Imam H. Shaik, Hitesh K. Agarwal, Keykavous Parang, and Reza Mehvar

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Attenuation of Corneal Myofibroblast Development through Nanoparticle-Mediated Soluble Transforming Growth Factor-β Type II Receptor (sTGFβRII) Gene Transfer, Ajay Sharma, Jason T. Rodier, Ashish Tandon, Alexander M. Klibanov, and Rajiv R. Mohan

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Melatonin Membrane Receptors in Peripheral Tissues: Distribution and Functions, Radomir M. Slominski, Russel J. Reiter, Natalia Schlabritz-Loutsevich, Rennolds S. Ostrom, and Andrzej T. Slominski

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Synthetic Peptides Derived from the Sequence of a Lasso Peptide Microcin J25 Show Antibacterial Activity, Rania Soudy, Liru Wang, and Kamaljit Kaur

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A New, Simple, Green and One-Pot Four-Component Synthesis of Bare and Poly(α, γ, L-Glutamic Acid) Capped Silver Nanoparticles, Magdalena Stevanović, Igor Savanović, Vuk Uskoković, Srečo D. Škapin, Ines Bračko, Uroš Jovanović, and Dragan Uskoković

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Development of a Men’s Preference for Testosterone Replacement Therapy (P-TRT) Instrument, Sheryl L. Szeinbach, Enrique Seoane-Vazquez, and Kent H. Summers

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Vorinostat: A Potent Agent to Prevent and Treat Laser-Induced Corneal Haze, Ashish Tandon, Jonathan C. K. Tovey, Michael R. Waggoner, Ajay Sharma, John W. Cowden, Daniel J. Gibson, Yuanjing Liu, Gregory S. Schultz, and Rajiv R. Mohan

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KSHV Infection of Endothelial Cells Manipulates CXCR7-Mediated Signaling: Implications for Kaposi’s Sarcoma Progression and Intervention, Jennifer Totonchy, Lisa Clepper, Janet Douglas, Liron Pantanowitz, Klaus Fruh, and Ashlee V. Moses

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Cytomegalovirus CC Chemokine Promotes Immune Cell Migration, Jennifer Totonchy, Michael Denton, Craig N. Kreklywich, Takeshi Andoh, Jessica M. Osborn, Daniel Chen, Ilhem Messaoudi, Susan L. Orloff, and Daniel N. Streblow

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Depression in Cardiac Patients: Underrecognized and Undertreated, Laura V. Tsu

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Dynamic Light Scattering and Microelectrophoresis: Main Prospects and Limitations, Vuk Uskoković

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On Love in the Realm of Science, Vuk Uskoković

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Ten Commandments for Writing a Meritable Scientific Paper, Vuk Uskoković

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Shape Effect in the Design of Nanowire Coated Microparticles as Transepithelial Drug Delivery Devices, Vuk Uskoković, Kunwoo Lee, Phin Peng Lee, Kathleen E. Fischer, and Tejal A. Dasai

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PEGylated Silicon Nanowire Coated Silica Microparticles for Drug Delivery across Intestinal Epithelium, Vuk Uskoković, Phin-Peng Lee, Laura Walsh, Kathleen Fischer, and Tejal Dasai

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Racial and Ethnic Disparities in Meeting Part D MTM Eligibility Criteria Among the Non-Medicare Population, Junling Wang, Lawrence M. Brown, and Song Hee Hong

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Targeting Nitric Oxide Signaling with nNOS Inhibitors As a Novel Strategy for the Therapy and Prevention of Human Melanoma, Zhen Yang, Bobbye J. Misner, Haitao Ji, Thomas L. Poulos, Richard B. Silverman, Frank L. Meyskens, and Sun Yang

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BSA Nanoparticles for siRNA Delivery: Coating Effects on Nanoparticle Properties, Plasma Protein Adsorption, and In Vitro siRNA Delivery, Haran Yogasundaram, Markian Stephan Bahniuk, Harsh-Deep Singh, Hamidreza Montazeri Aliabadi, Hasan Uludag, and Larry David Unsworth

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Assessment of the Activity of Ceftaroline Against Clinical Isolates of Penicillin-Intermediate and Penicillin-Resistant Streptococcus pneumoniae with elevated MICs of Ceftaroline Using an In Vitro Pharmacodynamic Model, George G. Zhanel, Chris Yachison, Kim Nichol, Heather Adam, Ayman M. Noreddin, Daryl J. Hoban, and James A. Karlowsky

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Structural Basis for Calmodulin as a Dynamic Calcium Sensor, Miao Zhang, Cameron Abrams, Liping Wang, Anthony Gizzi, Liping He, Ruihe Lin, Yuan Chen, Patrick J. Loll, John M. Pascal, and Ji-fang Zhang

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Identification of the Functional Binding Pocket for Compounds Targeting Small-Conductance Ca2+-Activated Potassium Channels, Miao Zhang, John M. Pascal, Marcel Schumann, Roger S. Armen, and Ji-fang Zhang

Submissions from 2011

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Calcium-Mediated Mechanisms of Cystic Expansion, Shakila Abdul-Majeed and Surya M. Nauli

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Dopamine Receptor Type 5 in the Primary Cilia Has Dual Chemo- and Mechano-Sensory Roles, Shakila Abdul-Majeed and Surya M. Nauli

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Polycystic Diseases in Visceral Organs, Shakila Abdul-Majeed and Surya M. Nauli

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Endothelial Cells from Humans and Mice with Polycystic Kidney Disease are Characterized by Polyploidy and Chromosome Segregation Defects Through Survivin Down-Regulation, Wissam A. AbouAlaiwi, Shobha Ratnam, Robert L. Booth, Jagesh V. Shaw, and Surya M. Nauli

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β-Adrenergic Receptors Stimulate IL-6 Production in Human Bronchial Smooth Muscle Cells: Enhancement by Non-Raft AC2 But Not Lipid Raft AC6, Amy S. Bogard and Rennolds S. Ostrom

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Human Bronchial Smooth Muscle Cells Express Adenylyl Cyclase Isoforms 2, 4 and 6 in Distinct Membrane Microdomains, Amy S. Bogard, Congfeng Xu, and Rennolds S. Ostrom

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Fatty Acyl Amide Dderivatives of Doxorubicin: Synthesis and In Vitro Anticancer Activities, Bhupender S. Chhikara, Nicole St. Jean, Deendayal Mandal, Anil Kumar, and Keykavous Parang

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Inhibition of Multi-Drug Resistant HIV-1 Reverse Transcriptase by Nucleoside Beta-Triphosphates, Chandravanu Dash, Yousef Ahmadibeni, Michael J. Hanley, Jui Pandhare, Mathias Gotte, Stuart F. J. Le Grice, and Keykavous Parang

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Multiple Protein Kinases Determine the Phosphorylated State of the Small Heat Shock Protein, HSP27, in SH-SY5Y Neuroblastoma Cells, Linda A. Dokas, Amy M. Malone, Frederick E. Williams, Surya M. Nauli, and William S. Messer Jr.

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Complex Microbiome Underlying Secondary and Primary Metabolism in the Tunicate-Prochloron Symbiosis, Mohamed S. Donia, W. Florian Fricke, Frédéric Partensky, James Cox, Sherif Elshahawi, James R. White, Adam M. Phillippy, Michael C. Schatz, Joern Piel, Martha G. Haygood, Jacques Ravel, and Eric W. Schmidt

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A Comparison of Pharmacist Travel-Health Specialists' versus Primary Care Providers' Recommendations for Travel-Related Medications, Vaccinations, and Patient Compliance in a College Health Setting, Melissa J. Durham, Jeffery A. Goad, Lawrence S. Neinstein, and Mimi Lou

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Lack of Primary Cilia Primes Shear-Induced Endothelial-to-Mesenchymal Transition, Anastasia D. Egorova, Padmini P.S.J. Khedoe, Marie-José T.H. Goumans, Bradley K. Yoder, Surya M. Nauli, Peter ten Dijke, Robert E. Poelmann, and Beerend P. Hierck

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Thiazolyl N-Benzyl-Substituted Acetamide Derivatives: Synthesis, Src Kinase Inhibitory and Anticancer Activities, Asal Fallah-Tafti, Alireza Foroumadi, Rakesh Tiwari, Amir Nasrolahi Shirazi, David G. Hangauer, Yahao Bu, Tahmineh Akbarzadeh, Keykavous Parang, and Abbas Shafiee

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The Immunosuppressive Activity of Polymeric Micellar Formulation of Cyclosporine A: In Vitro and In Vivo Studies, Samar Hamdy, Azita Haddadi, Anooshirvan Shayeganpour, Aws Alsamsan, Hamidreza Montazeri Aliabadi, and Afsaneh Lavasanifar

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Multimodal Spectral Imaging of Cells using a Transmission Diffraction Grating on a Light Microscope, Dragan Isailovic, Yang Xu, Tyler Copus, Suraj Saraswat, and Surya M. Nauli

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Substituted Coumarin Derivatives: Synthesis and Evaluation of Antiproliferative and Src Kinase Inhibitory Activities, Abha Kathuria, Sarah Jalal, Rakesh Tiwari, Amir Nasrolahi Shirazi, Shilpi Gupta, Shiv Kumar, Keykavous Parang, and Sunil K. Sharma

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Endothelin, Yoshifumi Kawanabe and Surya M. Nauli

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Synthesis of 3-phenylpyrazolopyrimidine-1,2,3-triazole Conjugates and Evaluation of Their Src Kinase Inhibitory and Anticancer Activities, Anil Kumar, Israr Ahmad, Bhupender S. Chhikara, Rakesh Tiwari, Deendayal Mandal, and Keykavous Parang

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Click Chemistry Inspired One-Pot Synthesis of 1, 4-disubstituted 1, 2, 3-triazoles and Their Src Kinase Inhibitory Activity, Dalip Kumar, V. Buchi Reddy, Anil Kumar, Deendayal Mandal, Rakesh Tiwari, and Keykavous Parang

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Efficacious and Safe Tissue-Selective Controlled Gene Therapy Approaches for the Cornea, Rajiv R. Mohan, Sunilima Sinha, Ashish Tandon, Rangan Gupta, Jonathan C. K. Tovey, and Ajay Sharma

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Significant Inhibition of Corneal Scarring in vivo with Tissue-Selective, Targeted AAV5 Decorin Gene Therapy, Rajiv R. Mohan, Ashish Tandon, Ajay Sharma, John W. Cowden, and Jonathan C. K. Tovey

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Targeted Decorin Gene Therapy Delivered with Adeno-Associated Virus Effectively Retards Corneal Neovascularization in vivo, Rajiv R. Mohan, Jonathan C. K. Tovey, Ajay Sharma, Gregory S. Schultz, John W. Cowden, and Ashish Tandon

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Editorial Focus: An ACE Inhibitor Improves Vascular Outcomes in a PKD Model, Surya M. Nauli

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The Mechanosensory Role of Primary Cilia in Vascular Hypertension, Surya M. Nauli, Xingjian Jin, and Beerend P. Hierck

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Cumulative Clinical Experience from Over a Decade of Use of Levofloxacin in Community Acquired Pneumonia; Critical Appraisal and Role in Therapy, Ayman M. Noreddin, Walid F. Elkhatib, Kenji M. Cunnion, and George G. Zhanel

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Improved Inactivation Effect of Bacteria Fabrication of Mesoporous Anatase Films with Fine Ag Nanoparticles Prepared by Coaxial Vacuum Arc Deposition, Hamid Oveisi, Simin Rahighi, Xiangfen Jiang, Yoshiaki Agawa, Ali Beitollahi, Soichi Wakatsuki, and Yusuke Yamauchi

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3-Substitued Indoles: One Pot Synthesis and Evaluation of Anticancer and Src Kinase Inhibitory Activities, V. Kameshwara Rao, Bhupender S. Chhikara, Amir Nasrolahi Shirazi, Rakesh Tiwari, Keykavous Parang, and Anil Kumar

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Comparative Pharmacodynamics of Ceftobiprole, Daptomycin, Linezolid, Telavancin, Tigecycline, and Vancomycin in the Treatment of Methicillin Resistant Staphylococcus aureus: A Monte Carlo Simulation Analysis, Ahmed H. Salem, Ehab A. Noreddin, George G. Zhanel, and Ayman M. Noreddin

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Polyethylenimine-Conjugated Gold Nanoparticles: Gene Transfer Potential and Low Toxicity in the Cornea, Ajay Sharma, Ashish Tandon, Jonathan C. K. Tovey, Rangan Gupta, J. David Robertson, Jennifer A. Fortune, Alexander M. Klibanov, John W. Cowden, Frank G. Rieger, and Rajiv R. Mohan

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Co-Creation of Experiential Qualities, Vuk Uskoković

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Turning the Paradigm Upside Down: Postdocs as Principal Investigators’ Mentors, Vuk Uskoković

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Hydrolysis of Amelogenin by Matrix Metalloprotease-20 Accelerates Mineralization in vitro, Vuk Uskoković, Feroz Khan, Haichuan Liu, Halina Ewa Witkowska, Li Zhu, Wu Li, and Stefan Habelitz

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Biomimetic Precipitation of Uniaxially Grown Calcium Phosphate Crystals from Full-Length Human Amelogenin Sols, Vuk Uskoković, Wu Li, and Stefan Habelitz

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Dynamic Light Scattering and Zeta Potential of Colloidal Mixtures of Amelogenin and Hydroxyapatite in Calcium and Phosphate Rich Ionic Milieus, Vuk Uskoković, Roselyn Odsinada, Sonia Djordjevic, and Stefan Habelitz

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Extrapolating Strategies for the Scientific and Technological Development of Underdeveloped Societies from the Examples of South Korea, Slovenia and Serbia, Vuk Uskoković and Dragan Uskoković

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Antivirulence Potential of TR-700 and Clindamycin on Clinical Isolates of Staphylococcus aureus Producing Phenol-Soluble Modulins, Jason Yamaki, Timothy Synold, and Annie Wong-Beringer

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Ceftaroline Pharmacodynamic Activity versus Community-Associated and Healthcare-Associated Methicillin-Resistant Staphylococcus aureus, Heteroresistant Vancomycin-Intermediate S. aureus, Vancomycin-Intermediate S. aureus and Vancomycin-Resistant S. aureus Using an In Vitro Model, George G. Zhanel, Emma Rossnagel, Kim Nichol, Lauren Cox, James A. Karlowsky, Sheryl Zelenitsky, Ayman M. Noreddin, and Daryl J. Hoban

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Altered Self-Assembly and Apatite Binding of Amelogenin Induced by N-terminal Proline Mutation, Li Zhu, Vuk Uskoković, Thuan Le, Pamela DenBesten, Yulei Huang, Stefan Habelitz, and Wu Li

Submissions from 2010

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Synthesis, Antiviral and Contraceptive Activities of Nucleoside-Sodium Cellulose Sulfate Acetate and Succinate Conjugates, Hitesh K. Agarwal, Anil Kumar, Gustavo F. Doncel, and Keykavous Parang

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Synthesis of Nucleoside 5′-O-α,β-methylene-β-triphosphates and Evaluation of Their Potency Towards Inhibition of HIV-1 Reverse Transcriptase, Yousef Ahmadibeni, Chandravanu Dash, M. J. Hanley, S. F. J. Le Grice, Hitesh K. Agarwal, and Keykavous Parang

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5¢-O-b,g-Methylenetriphosphate Derivatives of Nucleoside, Yousef Ahmadibeni, Chandravanu Dash, S. F. J. Le Grice, and Keykavous Parang

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Isolation and Cultivation of Equine Corneal Keratocytes, Fibroblasts and Myofibroblasts, Dylan G. Buss, Elizabeth A. Giuliano, Ajay Sharma, and Rajiv R. Mohan

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Efficacy and Safety of Mitomycin C as an Agent to Treat Corneal Scarring in Horses Using an in vitro Model, Dylan G. Buss, Ajay Sharma, Elizabeth A. Giuliano, and Rajiv R. Mohan

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Gene Delivery in the Equine Cornea: A Novel Therapeutic Strategy, Dylan G. Buss, Ajay Sharma, Elizabeth A. Giuliano, and Rajiv R. Mohan

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Development of Cytarabine Prodrugs and Delivery Systems for Leukemia Treatment, Bhupender S. Chhikara and Keykavous Parang

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Intravenous Artesunate for Severe Malaria, Karl M. Hess, Jeffery A. Goad, and Paul M. Arguin

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Selective Binding of Linear Ubiquitin Chains to NEMO in NF-κB Activation, Fumiyo Ikeda, Simin Rahighi, Soichi Wakatsuki, and Ivan Dikic

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In Vitro Release of Indian Penny Wort, Walnut, and Turmeric from Topical Preparations Using Two Different Types of Membranes, Sonia Khiljee, Nisar Ur Rehman, Muhammad Khan Sarfaz, Hamidreza Montazeri Aliabadi, Tanzila Khiljee, and Raimar Löbenberg

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Fibroblast Specific Expression of AC6 Enhances ß-Adrenergic and Prostacyclin Signaling and Blunts Bleomycin-Induced Pulmonary Fibrosis, Xiaoqiu Liu, Shu Qiang Sun, Muthusamy Thangavel, Joseph Kaminsky, Joseph Kaminsky, Louisa Balazs, and Rennolds S. Ostrom

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A Participation Requirement to Engage Students in a Pharmacokinetics Course Synchronously Taught at a Local and Distant Campus, Reza Mehvar

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Vector Delivery Technique Affects Gene Transfer in the Cornea in vivo, Rajiv R. Mohan, Ajay Sharma, Tyler C. Cebulko, and Ashish Tandon

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Good Research Practices for Measuring Drug Costs in Cost-Effectiveness Analyses: Medicare, Medicaid and Other US Government Payers Perspectives: The ISPOR Drug Cost Task Force Report—Part IV, C. Daniel Mullins, Brian Seal, Enrique Seoane-Vazquez, Jayashri Sankaranarayanan, Carl V. Asche, Ravishankar Jayadevappa, Won Chan Lee, Dorothy K. Romanus, Junling Wang, Joel W. Hay, and Jim Smeeding

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A Comparative Study of Embedded and Anesthetized Zebrafish in Vivo on Myocardiac Calcium Oscillation and Heart Muscle Contraction, Brian S. Muntean, Christine M. Horvat, James H. Behler, Wissam A. AbouAlaiwi, Andromeda M. Nauli, Frederick E. Williams, and Surya M. Nauli

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Impaired M3 and Enhanced M2 Muscarinic Receptor Contractile Function in a Streptozotocin Model of Mouse Diabetic Urinary Bladder, K. J. Pak, Rennolds S. Ostrom, M. Matsui, and F. J. Ehlert

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The M2 Muscarinic Receptor Inhibits the Development of Streptozotocin-Induced Neuropathy of Mouse Urinary Bladder, K. J. Pak, Rennolds S. Ostrom, M. Matsui, and F. J. Ehlert

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Plasma Pharmacokinetics and Tissue Disposition of Novel Dextran- Methylprednisolone Conjugates with Peptide Linkers in Rats, Suman Penugonda, Hitesh K. Agarwal, Keykavous Parang, and Reza Mehvar

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Failure to ubiquitinate c-Met Leads to Hyperactivation of mTOR Signaling in a Mouse Model of Autosomal Dominant Polycystic Kidney Disease, Shan Qin, Mary Taglienti, Surya M. Nauli, Leah Contrino, Ayumi Takakura, Jing Zhou, and Jordan A. Kreidberg

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Hypertension in Autosomal Dominant Polycystic Kidney Disease: A Clinical and Basic Science Perspective, Shobha Ratnam and Surya M. Nauli

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Practice Patterns for Antibiotic De-escalation in Culture-Negative Healthcare-Associated Pneumonia, M. Schlueter, C. James, A. Dominguez, Laura V. Tsu, and G. Seymann

AAV Serotype Influences Gene Transfer in Corneal Stroma in vivo, Ajay Sharma

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Localization of Angiotensin Converting Enzyme in Rabbit Cornea and Its Role in Controlling Corneal Angiogenesis in vivo, Ajay Sharma, Daniel I. Bettis, John W. Cowden, and Rajiv R. Mohan

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"Transduction Efficiency of AAV 2/6, 2/8 and 2/9 Vectors for Delivering Genes in Human Corneal Fibroblasts ", Ajay Sharma, Arkasubhra Ghosh, Eric T. Hansen, Jason M. Newman, and Rajiv R. Mohan

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AAV Serotype Influences Gene Transfer in Corneal Stroma in vivo, Ajay Sharma, Jonathan C. K. Tovey, Arkasubhra Ghosh, and Rajiv R. Mohan

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Polystyrene-Supported Aluminum Chloride as an Efficient and Reusable Catalyst for Condensation of Indole with Various Carbonyl Compounds, Bahman Tamami, Amir Nasrolahi Shirazi, and Kaveh Parvanak Borujeni

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Role of Transforming Growth Factor Beta in Corneal Function, Biology and Pathology, Ashish Tandon, Jonathan C. K. Tovey, Ajay Sharma, Rangan Gupta, and Rajiv R. Mohan

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Synthesis and Evaluation of Conformationally Constrained Peptide Analogues as the Src SH3 Domain Binding Ligands, Rakesh Tiwari, Alex Brown, Seetha Narramaneni, Gongqin Sun, and Keykavous Parang

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HCMV pUS28 Initiates Pro-Migratory Signaling via Activation of Pyk2 Kinase, Jennifer Totonchy, Susan Varnum, Ryan Melnychuk, Patricia Smith, Ljiliana Pasa-Tolic, Janani I. Shutthanadan, and Daniel N. Streblow

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Major Challenges for the Modern Chemistry in Particular and Science in General, Vuk Uskoković

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Morphological Study of Emulsion-Assisted Cholesterol Precipitation Processes, Vuk Uskoković

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Prospects and Pits on the Path of Biomimetics: The Case of Tooth Enamel, Vuk Uskoković

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The Metaphorical Model: The Bridge between Science and Religion, Vuk Uskoković

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Nanotechnology in Dental Sciences: Moving Towards a Finer Way of Doing Dentistry, Vuk Uskoković and Luiz Eduardo Bertassoni

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Zeta-Potential and Particle Size Analysis of Recombinant Human Amelogenins, Vuk Uskoković; Z. Castiglione; P. Cubas; L. Zhu; W, Li; and S. Habelitz

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Strategies for the Scientific Progress of the Developing Countries in the New Millennium: The Case of Serbia in Comparison with Slovenia and South Korea, Vuk Uskoković, Milica Ševkušić, and Dragan P. Uskoković

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Nanosized Hydroxyapatite and Other Calcium Phosphates: Chemistry of Formation and Application as Drug and Gene Delivery Agents, Vuk Uskoković and Dragan Uskoković

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Disparity Implications of Medicare Eligibility Criteria for Medication Therapy Management Services, Junling Wang, C. Daniel Mullins, Lawrence M. Brown, Ya-Chen Tina Shih, Samuel Dagogo-Jack, Song Hee Hong, and William C. Cushman

Submissions from 2009

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Primary Cilia: Highly Sophisticated Biological Sensors, Wissam A. AbouAlaiwi, Shao T. Lo, and Surya M. Nauli