Below you may find selected research articles from faculty in the School of Pharmacy.

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Submissions from 2005

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Alterations in the Expression of the Apurinic/Apyrimidinic Endonuclease-1/redox Factor-1 (APE/Ref-1) in Human Melanoma and Identification of the Therapeutic Potential of Resveratrol as an APE/Ref-1 Inhibitor, Sun Yang, Kaikobad Irani, Susan E. Heffron, Frances Jurnak, and Frank L. Meyskens Jr.

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Alterations in Activating Protein 1 Composition Correlate with Phenotypic Differentiation Changes Induced by Resveratrol in Human Melanoma, Sun Yang and Frank L. Meyskens Jr.

Submissions from 2004

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Gating of the Polycystin Ion Channel Signaling Complex in Neurons and Kidney Cells, Patrick Delmas, Surya M. Nauli, Xiaogang Li, Bertrand Coste, Nancy Osorio, Marcel Crest, David A. Brown, and Jing Zhou

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Inhibitors of Protein Kinase Signaling Pathways Emerging Therapies for Cardiovascular Disease, Thomas Force, Keisuke Kuida, Mark Namchuk, Keykavous Parang, and John M. Kyriakis

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Cyclic AMP-Elevating Agents and Adenylyl Cyclase Overexpression Promote an Anti-Fibrotic Phenotype in Pulmonary Fibroblasts, Xiaoqiu Liu, Rennolds S. Ostrom, and Paul A. Insel

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Non-prescription and Household Substances of Abuse, J. Mallari, L. Nguyen, and Jeffery A. Goad

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The Relationship Among Pharmacokinetic Parameters: Effects of Altered Kinetics on the Drug Plasma Concentration-Time Profiles, Reza Mehvar

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Hepatic Disposition of Cyclosporine A in Isolated Perfused Rat Livers, Reza Mehvar and Anjaneya Chimalakonda

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Nitric Oxide Inhibition of Adenylyl Cyclase Type 6 Activity is Dependent upon Lipid Rafts and Caveolin Signaling Complexes, Rennolds S. Ostrom, Richard A. Bundey, and Paul A. Insel

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The Evolving Role of Lipid Rafts and Caveolae in G Protein-Coupled Receptor Signaling: Implications for Molecular Pharmacology, Rennolds S. Ostrom and Paul A. Insel

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Guidelines for Manuscripts Describing Instructional Design or Assessment: The IDEAS Format, Therese Poirier, Michael Crouch, Emily Hak, George MacKinnon, Reza Mehvar, and Mary Monk-Tutor

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Hepatitis B Vaccination for Patients with Chronic Renal Failure, Robert J. Schroth, Carol A. Hitchon, Julia Uhanova, Ayman M. Noreddin, Shayne P. Taback, Michael Moffatt, and James M. Zacharias

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Designing Fluoroquinolone Breakpoints for Streptococcus pneumoniae Using Genetics instead of Pharmacokinetics/Pharmacodynamics, H. J. Smith, Ayman M. Noreddin, C. G. Siemens, K. N. Schurek, J. Greisman, C. J. Hoban, D. J. Hoban, and G. G. Zhanel

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Synthesis of Nanocrystalline Nickel-Zinc Ferrites via a Microemulsion Route, Vuk Uskoković and Miha Drofenik

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The Characterization of Nanosized Nickel-Zinc Ferrites Synthesized within Reverse Micelles of CTAB/1-Hexanol/Water Microemulsion, Vuk Uskoković, Miha Drofenik, and Irena Ban

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Hepatic Disposition and Effects of Nitric Oxide Donors: Rapid and Concentration-Dependent Reduction in the Cytochrome P450-Mediated Drug Metabolism in Isolated Perfused Rat Livers, Ragini Vuppugalla and Reza Mehvar

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Short-Term Inhibitory Effects of Nitric Oxide on Cytochrome P450-mediated Drug Metabolism: Time Dependency and Reversibility Profiles in Isolated Perfused Rat Livers, Ragini Vuppugalla and Reza Mehvar

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Impaired Ca2+ Store Functions in Skeletal and Cardiac Muscle Cells from Sarcalumenin-Deficient Mice, Morikatsu Yoshida, Susumu Minamisawa, Miei Shimura, Shinji Komazaki, Hideaki Kume, Miao Zhang, Kiyoyuki Matsumura, Miyuki Nishi, Minori Saito, Yasutake Saeki, Yoshihiro Ishikawa, Teruyuki Yanagisawa, and Hiroshi Takeshima

Submissions from 2003

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A New Era in Pharmacy School Education, Lawrence M. Brown

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Hemorrhagic Fever Viruses, Jeffery A. Goad and J Nguyen

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Quality Assessment of a Collaborative Approach for Decreasing Drug-Related Morbidity and Achieving Therapeutic Goals, Brian J. Issetts, Lawrence M. Brown, Stephen W. Schondelmeyer, and Lois A. Lenarz

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Determination of the Substrate-Docking Site of Protein Tyrosine Kinase C-terminal Src Kinase, Sungsoo Lee, Xiaofeng Lin, Nguyen Hai Nam, Keykavous Parang, and Gongqin Sun

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Immortalized Epithelial Cells from Human Autosomal Dominant Polycystic Kidney Cysts, Mahmoud Loghman-Adham, Surya M. Nauli, Carlos E. Soto, Barbara Kariuki, and Jing Zhou

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Hypertonic Stress Co-Stimulates T Cell Il-2 Expression Through a Feedback Mechanism Involving ATP Release and P2 Receptor Activation of P38 Map Kinase, William H. Loomis, Sachiko Namiki, Rennolds S. Ostrom, Paul A. Insel, and Wolfgang G. Junger

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Angiotensin II Enhances Adenylyl Cyclase Signaling via Ca2+/Calmodulin. Gq-Gs Cross-Talk Regulates Collagen Production in Cardiac Fibroblasts, Rennolds S. Ostrom, Jennifer E. Naugle, Miki Hase, Caroline Gregorian, James S. Swaney, Paul A. Insel, Laurence L. Brunton, and J. Gary Meszaros

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Career Pathways Evaluation Program: 2002 Pharmacist Profile Survey, Jon C. Schommer, Lawrence M. Brown, Marsha K. Millonig, and Elliott M. Sogol

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Career Pathways for Pharmacists, Jon C. Schommer, Elliott M. Sogol, and Lawrence M. Brown

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Price of Pharmaceuticals, Value, R&D, and Intergenerational Equity, Enrique Seoane-Vazquez

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Human Cytomegalovirus Chemokine Receptor US28-Induced Smooth Muscle Cell Migration is Mediated by Focal Adhesion Kinase and Src, Daniel N. Streblow, Jennifer Totonchy, Patsy Smith, Ryan Melnychuk, Laurel Hall, Dora Pancheva, Martine Smit, Paola Casarosa, David D. Schlaepfer, and Jay A. Nelson

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Synthesis of Nanocrystalline Nickel-Zinc Ferrites within Reverse Micelles, Vuk Uskoković and Miha Drofenik

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Pharmacodynamic Activity of Azithromycin Against Macrolide-Susceptible and Macrolide-Resistant Streptococcus pneumoniae Simulating Clinically Achievable Free Serum, Epithelial Lining Fluid and Middle Ear Fluid Concentrations, George G. Zhanel, Mel DeCorby, Ayman M. Noreddin, Chris Mendoza, Andrew Cumming, Kim Nichol, Aleksandra Wierzbowski, and Daryl J. Hoban

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Antibiotic Activity Against Urinary Tract Infection (UTI) Isolates of Vancomycin-Resistant Enterococci (VRE): Results from the 2002 North American Vancomycin Resistant Enterococci Susceptibility Study (NAVRESS), George G. Zhanel, Nancy Laing, Kim Nichol, Lorraine P. Palatnick, Ayman M. Noreddin, Tamiko Hisanaga, Jack L. Johnson, NAVRESS Group, and Daryl J. Hoban

Submissions from 2002

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Outcome Assessment in a PharmD Program: The Texas Tech Experience, Reza Mehvar and Robert B. Supernaw

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Pharmacodynamic Modeling of Clarithromycin Against Macrolide-Resistant (PCR positive mefA or ermB) Streptococcus pneumoniae Simulating Clinically Achievable Free Drug Serum and Epithelial Lining Fluid Concentrations, Ayman M. Noreddin, Danielle Roberts, Kim Nichol, Aleksandra Wierzbowski, Daryl J. Hoban, and George G. Zhanel

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New Determinants of Receptor-Effector Coupling: Trafficking and Compartmentation in Membrane Microdomains, Rennolds S. Ostrom

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Localization of Adenylyl Cyclase Isoforms and G Protein-Coupled Receptors in Vascular Smooth Muscle Cells: Expression in Caveolin-Rich and Non-Caveolin Domains, Rennolds S. Ostrom, Xiaoqiu Liu, Brian P. Head, Caroline Gregorian, Tammy M. Seasholtz, and Paul A. Insel

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Mechanisms of cGMP-Induced Cerebral Vasodilatation: Contractile Agonist and Developmental Age Make a Difference, William J. Pierce and Surya M. Nauli

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Distribution of Functional P2X1-like Receptor in Isolated Rabbit Arteries, Lei-Ming Ren and Miao Zhang

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Polymerase Chain Reaction: An Emerging Tool for Research in Pharmacology, Rishi Sharma, Manjeet Singh, and Ajay Sharma

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The 2001 National Pharmacy Consumer Survey, Andy Stergachis, Lucinda L. Maine, and Lawrence M. Brown

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Methodology for the Assessment of Competence and the Definition of Deficiencies of Students in All Levels of the Curriculum, Robert B. Supernaw and Reza Mehvar

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Synthesis and Characterization of Hydroxyapatite-Collagen Biocomposite Materials, Vuk Uskoković, Nenad Ignjatović, and Nadejda Petranović

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Pharmacodynamic Activity of Fluoroquinolones Against Ciprofloxacin-Resistant Streptococcus pneumoniae, George G. Zhanel, Danielle Roberts, Andrew Waltky, Nancy Laing, Kim Nichol, Heather Smith, Ayman M. Noreddin, Tracy Bellyou, and Daryl J. Hoban

Submissions from 2001

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Principles of Nonlinear Pharmacokinetics, Reza Mehvar

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Stereospecific Pharmacokinetics and Pharmacodynamics of Beta-Adrenergic Blockers in Humans, Reza Mehvar and Dion R. Brocks

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Developmental Changes in Ryanodine- and IP3-sensitive Ca2+ Pools in Ovine Basilar Artery, Surya M. Nauli, James M. Williams, S. E. Akopov, L. Zhang, and William J. Pearce

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Maturation Depresses cGMP-Mediated Decreases in [Ca2+]i and Ca2+ Sensitivity in Ovine Cranial Arteries, Surya M. Nauli, Lubo Zhang, and William J. Pearce

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Key Role for Constitutive Cyclooxygenase Type 2 of MDCK Cells in Basal Signaling and Response to Released ATP, Rennolds S. Ostrom, Caroline Gregorian, Ryan M. Drenan, Kathryn Gabot, Brinda K. Rana, and Paul A. Insel

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Receptor Number and Caveolar Co-Localization Determine Receptor Coupling Efficiency to Adenylyl Cyclase, Rennolds S. Ostrom, Caroline Gregorian, Ryan M. Drenan, Yang Xiang, John W. Regan, and Paul A. Insel

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Antioxidation Activity of DHEA and Its Mechanisms, Sun Yang and Han Rui

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Dextran-Methylprednisolone Succinate as a Prodrug of Methylprednisolone: Plasma and Tissue Disposition, Xiaoping Zhang and Reza Mehvar

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RGS-PX1, Gap for Gas and a Sorting Nexin in Vesicular Trafficking, Bin Zheng, Yong-Chao Ma, Rennolds S. Ostrom, Christine Lavoie, Gordon N. Gill, Paul A. Insel, Xin-Yun Huang, and Marilyn G. Farquhar

Submissions from 2000

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The Common Cold: What Pharmacists Need to Know, Peggy Han, Peggy McMillan, and Jeffery A. Goad

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White Paper: Certification, Credentials, and Credentialing in Pharmacy, Donald Kishi, Jeffery A. Goad, Nancy Korman, Teresa Miller, Mary Ferrill, and Holly Strom

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Creation of a Dynamic Question Database for Pharmacokinetics, Reza Mehvar

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Development and Application of an On-line Module for Teaching Bayesian Forecasting Principles in a Clinical Pharmacokinetics Course, Reza Mehvar

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Modulation of the Pharmacokinetics and Pharmacodynamics of Proteins by Polyethylene Glycol Conjugation, Reza Mehvar

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Cellular Release of and Response to ATP As Key Determinants of the Set-Point of Signal Transduction Pathways, Rennolds S. Ostrom, Caroline Gregorian, and Paul A. Insel

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Stoichiometry and Compartmentation in G Protein-Coupled Receptor Signaling: Implications for Therapeutic Interventions Involving Gs, Rennolds S. Ostrom, Steven R. Post, and Paul A. Insel

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Selective Enhancement of β-Adrenergic Receptor Signaling by Overexpression of Adenylyl Cyclase 6: Co-Localization of Receptor and Adenylyl Cyclase in Caveolae of Cardiac Myocytes, Rennolds S. Ostrom, Jonathan D. Violin, Scott Coleman, and Paul A. Insel

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Novel Approaches for Designing 5'-O-Ester Prodrugs of 3'-Azido-2'3'-Dideoxythymidine (AZT), Keykavous Parang, Leonard I. Wiebe, and Edward E. Knaus

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Effect of Actinomycin D and Cycloheximide on Ischemic Preconditioning-Induced Delayed Cardioprotective Effect in Rats, Devinder Singh, Ajay Sharma, and Manjeet Singh

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Role of KATP Channels in Reduced Antinociceptive Effect of Morphine in Streptozotocin-Induced Diabetic Mice, Vivek Sood, Ajay Sharma, and Manjeet Singh

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Accuracy of Electrocardiogram Reading by Family Practice Residents, Denise K.C. Sur, Lily Kaye, Michael Mikus, Jeffery A. Goad, and Anthony Morena

Submissions from 1999

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Reversible Nonthrombocytopenic Palpable Purpura Associated with Metoclopramide, Jeffery A. Goad

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Reimbursement for Pharmaceutical Care Services: The California Experience, Jeffery A. Goad, Kathleen Johnson, and Michael Rudolph

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On-Line, Individualized, and Interactive Pharmacokinetic Scenarios with Immediate Grading and Feedback and Potential for Use by Multiple Instructors, Reza Mehvar

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Comparison of Functional Antagonism Between Isoproterenol and M2 Muscarinic Receptors in Guinea Pig Ileum and Trachea, Rennolds S. Ostrom and Frederick J. Ehlert

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Caveolar Microdomains of the Sarcolemma: Compartmentation of Signaling Molecules Comes of Age, Rennolds S. Ostrom and Paul A. Insel

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Protein Adducts of Iso[4]levuglandin E2, a Product of the Isoprostane Pathway, in Oxidized Low Density Lipoprotein, Robert G. Salomon, Wei Sha, Cynthia Brame, Kamaljit Kaur, Ganesamoorthy Subbanagounder, June O'Neil, Henry F. Hoff, and L. Jackson Roberts II

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Inhibition of cPLA2-Mediated Arachidonic Acid Release by Cyclic AMP Defines a Negative Feedback Loop for P2Y-Receptor Activation in Mdck-D1 Cells, Mingzhao Xing, Steven Post, Rennolds S. Ostrom, Michael Samardzija, and Paul A. Insel

Submissions from 1998

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Pharmacokinetic-Based Design and Modification of Dosage Regimens, Reza Mehvar

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M2 Muscarinic Receptors Inhibit Forskolin- But Not Isoproterenol-Mediated Relaxation in Bovine Trachea, Rennolds S. Ostrom and Frederick J. Ehlert

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In Vitro Anti-Hepatitis B Virus Activities of 5’-O-Myristoyl Analogue Derivatives of 3’-Fluoro-2’,3’-dideoxythymidine (FLT) and 3’-Azido-2’,3’- dideoxythymidine (AZT), Keykavous Parang, Leonard I. Wiebe, Edward E. Knaus, Jyy-Shiang Huang, and David L. Tyrrell

Submissions from 1997

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Computer-Assisted Generation and Grading of Pharmacokinetics Assignments in a Problem-Solving Course, Reza Mehvar

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Kinetics of Hepatic Accumulation of Dextrans in Isolated Perfused Rat Livers, Reza Mehvar

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M2 Muscarinic Receptor Inhibition of Agonist-Induced Cyclic Adenosine Monophosphate Accumulation and Relaxation in the Guinea Pig Ileum, Rennolds S. Ostrom and Frederick J. Ehlert

Submissions from 1996

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ls There Any Risk of a Withdrawal Syndrome Associated with Abrupt Discontinuation of Selective Serotonin Reuptake Inhibitors?, Rene A. Endow, Mary Gutierrez, and Michael Z. Wincor

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Pharmacist and Patient Education of Inhaler Technique, Ayman M. Noreddin, K. Al-Khamis, S. Bawazir, O. Ibrahim, T. Al-Najjar, and M. Al-Hassan

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What is the Risk of Teratogenicity with the Use of Selective Serotonin Reuptake Inhibitors During Pregnancy?, Michael Z. Wincor, Mary Gutierrez, and Ann Nguyen

Submissions from 1994

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Question: What is the difference between Volmax® and Proventil Repetabs®?, Jeffery A. Goad, Robert Andonian, Chris Chang, and Greg Thompson

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Outpatient Administration of Paclitaxel, Siu Fun Wong

Submissions from 1992

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Phosphorylation of the Rex Protein of Human T-Cell Leukemia Virus Type 1, Yoshifumi Adachi, Terry D. Copeland, Chiaki Takahashi, Tetsuya Nosaka, Aftab Ahmed, Stephen Oroszlan, and Masakazu Hatanaka

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Update on Anxiolytics and Hypnotics, Lynn Osako, Mary Gutierrez, and Michael Z. Wincor

Submissions from 1989

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The Amino Acid Sequence of the Adult Sumatran Tiger (Panthera tigris, Carnivora) Hemoglobins, Meeno Jahan, Aftab Ahmed, Gerhard Braunitzer, and Reinhard Göltenboth

Submissions from 1988

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Hemoglobin E B-Thalassemia in a Pakistani Family, Aftab Ahmed, Atiya Abbasi, Gerhard Braunitzer, and Zafar H. Zaidi

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Liquid-Chromatographic Assay of Ibuprofen Enantiomersin Plasma, Reza Mehvar, Fakhreddin Jamali, and Franco M. Pasutto

Submissions from 1987

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The Primary Structure of Hemoglobins of the Adult Jaguar (Panthera onco, Carnivora), Aftab Ahmed, Meeno Jahan, Zafar H. Zaidi, Gerhard Braunitzer, and Reinhard Göltenboth

Submissions from 1986

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Abnormal hemoglobin11 - Hb (Karachi), An a-Chain Abnormality at Position 5 Ala Pro, Aftab Ahmed, Zafar H. Zaidi, and S. Ehsanullah