Document Type
Article
Publication Date
6-13-2011
Abstract
Staphylococcus aureus strains (n = 50) causing complicated skin and skin structure infections produced various levels of phenol-soluble modulin alpha-type (PSMα) peptides; some produced more than twice that produced by the control strain (LAC USA300). TR-700 (oxazolidinone) and clindamycin strongly inhibited PSM production at one-half the MIC but exhibited weak to modest induction at one-fourth and one-eighth the MICs, primarily in low producers. Adequate dosing of these agents is emphasized to minimize the potential for paradoxical induction of virulence.
Recommended Citation
Yamaki J, Synold T, Wong-Beringer A. Antivirulence Potential of TR-700 and Clindamycin on Clinical Isolates of Staphylococcus aureus Producing Phenol-Soluble Modulins. Antimicrobial Agents and Chemotherapy. 2011;55(9):4432-4435. doi:10.1128/AAC.00122-11.
Copyright
American Society for Microbiology
Included in
Amino Acids, Peptides, and Proteins Commons, Bacteria Commons, Other Pharmacy and Pharmaceutical Sciences Commons, Skin and Connective Tissue Diseases Commons
Comments
This article was originally published in Antimicrobial Agents and Chemotherapy, volume 55, issue 9, in 2011. DOI: 10.1128/AAC.00122-11