Ruthmycin, a New Tetracyclic Polyketide from Streptomyces sp. RM-4-15

Authors

Xiachang Wang, University of Kentucky
Sherif Elshahawi, Chapman UniversityFollow
Khaled A. Shaaban, University of Kentucky
Lei Fang, University of Kentucky
Larissa V. Ponomareva, University of Kentucky
Yinan Zhang, University of Kentucky
Gregory C. Copley, University of Kentucky
James C. Hower, University of Kentucky
Chang-Guo Zhan, University of Kentucky
Madan K. Kharel, University of Kentucky
Jon S. Thorson, University of Kentucky

Document Type

Article

Publication Date

12-16-2013

Abstract

The isolation and structural elucidation of a new tetracyclic polyketide (ruthmycin) from Streptomyces sp. RM-4-15, a bacteria isolated near thermal vents from the Ruth Mullins underground coal mine fire in eastern Kentucky, is reported. In comparison to the well-established frenolicin core scaffold, ruthmycin possesses an unprecedented signature C3 bridge and corresponding fused six member ring. Preliminary in vitro antibacterial, anticancer and antifungal assays revealed ruthmycin to display moderate antifungal activity.

Comments

This article was originally published in Organic Letters, volume 16, issue 2, in 2014. https://doi.org/10.1021/ol4033418

Recommended Citation

Wang X, Elshahawi SI, Shaaban KA, et al. Ruthmycin, a new tetracyclic polyketide from Streptomyces sp. RM-4-15. Org. Lett. 2014;16(2):456-459.https://doi.org/10.1021/ol4033418

Copyright

American Chemical Society