N-Myristoylglutamic Acid Derivative of 3′-Fluoro-3′- Deoxythymidine as an Organogel

Authors

Bhupender S. Chhikara, University of Rhode Island
Rakesh Tiwari, Chapman UniversityFollow
Keykavous Parang, Chapman UniversityFollow

Document Type

Article

Publication Date

2012

Abstract

Designing microbicidal gels of anti-HIV drugs for local application to prevent HIV infection is a subject of major interest. 3′-Fluoro-3′-deoxythymidine (FLT), a nucleoside reverse transcriptase inhibitor (NRTI), was conjugated with a N-myristoylglutamate scaffold. The conjugate showed gelation at 1% (w/w) in different organic solvents, such as toluene, dichloromethane, and chloroform. The gels were opaque and stable at room temperature. The results indicate that myristoyl glutamate derivative of FLT can form an organogel. The gel could have potential application as a topical anti-HIV microbicidal agent.

Comments

NOTICE: this is the author’s version of a work that was accepted for publication in Tetrahedron Letters. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Tetrahedron Letters, volume 53, issue 39, in 2012. DOI: 10.1016/j.tetlet.2012.07.101

Recommended Citation

Chhikara, Bhupender S., Rakesh Tiwari, and Keykavous Parang. "N-Myristoylglutamic acid derivative of 3′-fluoro-3′-deoxythymidine as an organogel." Tetrahedron letters 53.39 (2012): 5335-5337.
DOI: 10.1016/j.tetlet.2012.07.101

Copyright

Elsevier