Selectivity of the Ubiquitin-Binding Modules

Authors

Simin Rahighi, Chapman UniversityFollow
Ivan Dikic, Goethe University

Document Type

Article

Publication Date

5-5-2012

Abstract

Ubiquitin-binding modules are constituents of cellular proteins that mediate the effects of ubiquitylation by making transient, non-covalent interactions with ubiquitin molecules. While some ubiquitin- binding modules bind single ubiquitin moieties, others are selective for specific ubiquitin chains of different linkage types and lengths. In recent years, functions of ubiquitin chains that are polymerized through their Lys or N-terminal Met (i.e. linear chains) residues have been linked to a variety of cellular processes. Selectivity of ubiquitin-binding modules for different ubiquitin chain types appears as a key to the distinct regulatory consequences during protein quality control pathways, receptor endocytosis, gene transcription, signaling via the NF-jB pathway, and autophagy.

Comments

This article was originally published in FEBS Letters, volume 586, in 2012. DOI: 10.1016/j.febslet.2012.04.053

Recommended Citation

Simin Rahighi, Ivan Dikic (2012). Selectivity of the ubiquitin-binding modules. FEBS Lett. 586, 2705-2710. doi: 10.1016/j.febslet.2012.04.053

Copyright

Federation of European Biochemical Societies

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.