Below you may find selected research articles from faculty in the School of Pharmacy.

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Submissions from 2009

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Ciliary Polycystin-2 Is a Mechanosensitive Calcium Channel Involved in Nitric Oxide Signaling Cascades, Wissam A. AbouAlaiwi, Maki Takahashi, Blair Mell, Thomas J. Jones, Shobha Ratnam, Robert J. Kolb, and Surya M. Nauli

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Synthesis of Nucleoside Mono-, Di-, and Triphosphoramidates from Solid-Phase cyclo Saligenyl Phosphitylating Reagents, Yousef Ahmadibeni, Rakesh Tiwari, Gongqin Sun, and Keykavous Parang

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The Proteolytic Stability and Cytotoxicity Studies of l‐Aspartic Acid and l‐Diaminopropionic Acid derived β‐Peptides and a Mixed α/β‐Peptide, Sahar Ahmed and Kamaljit Kaur

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Rat Cytomegalovirus Infection Depletes MHC II in Bone Marrow Derived Dendritic Cells, Carmen C. Baca Jones, Craig N. Kreklywich, Ilhem Messaoudi, Jennifer Totonchy, Erin McCartney, Susan L. Orloff, Jay A. Nelson, and Daniel N. Streblow

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The First Total Synthesis of (±)-4-methoxydecanoic Acid: A Novel Antifungal Fatty Acid, Nestor Carballeira, Carlos Miranda, and Keykavous Parang

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Novel Approach Against Central Venous Catheter Associated Infection with Acinetobacter baumannii Biofilm, Walid Elkhatib and Ayman M. Noreddin

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The Guinea Pig Ileum Lacks the Direct, High-Potency, M2-Muscarinic, Contractile Mechanism of the Mouse Ileum, Michael T. Griffin, Minoru Matsui, Rennolds S. Ostrom, and Frederick J. Ehlert

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Isoniazid Completion Rates for Latent Tuberculosis Infection Among College Students Managed by a Community Pharmacist, Karl M. Hess, Jeffery A. Goad, Joanne Wu, and Kathleen Johnson

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Eugenia jambolana Lam. Berry Extract Inhibits Growth and Induces Apoptosis of Human Breast Cancer but Not Non-Tumorigenic Breast Cells, Liya Li, Lynn S. Adams, Caroline Killian, Aftab Ahmed, and Navindra P. Seeram

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Pharmacodynamic Target Attainment Potential of Azithromycin, Clarithromycin and Telithromycin in Serum and Epithelial Lining Fluid (ELF) of Community Acquired Pneumonia (CAP) Patients with Penicillin-Susceptible, Intermediate and Resistant Streptococcus pneumoniae, Ayman M. Noreddin, Walid El-Khatib, Jason Aolie, Ahmed H. Salem, and George G. Zhanel

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Updated Guidelines for Manuscripts Describing Instructional Design and Assessment: The IDEAS Format, Therese Poirier, Michael Crouch, George MacKinnon, Reza Mehvar, and Mary Monk-Tutor

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Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-κB Activation, Simin Rahighi, Fumiyo Ikeda, Masato Kawasaki, Masato Akutsu, Nobuhiro Suzuki, Ryuichi Kato, Tobias Kensche, Tamami Uejima, Stuart Bloor, David Komander, Felix Randow, Soichi Wakatsuki, and Ivan Dikic

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Provision of Health Care Services in Canada: Challenges and Opportunities, Rosa Rodriguez-Monguio, Enrique Seoane-Vazquez, and Fernando Antoñanzas Villar

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Trichostatin A Inhibits Corneal Haze in vitro and in vivo, Ajay Sharma, Maneesh M. Mehan, Sunilima Sinha, John W. Cowden, and Rajiv R. Mohan

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Localization and Coupling of Adenylyl Cyclase Isoforms 2, 3 and 6 With G Protein-Coupled Receptors in Mouse Bronchial Smooth Muscle Cells, Muthusamy Thangavel, Piyatilake Adris, and Rennolds S. Ostrom

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The C1 and C2 Domains Target Human Type 6 Adenylyl Cyclase to Lipid Rafts and Caveolae, Muthusamy Thangavel, Xiaoqiu Liu, Shu Qiang Sun, Joseph Kaminsky, and Rennolds S. Ostrom

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Differential Ligand Binding to a Human Cytomegalovirus Chemokine Receptor Determines Cell Type-Specific Motility, Jennifer Totonchy, Ryan Melnychuk, Patricia P. Smith, Joshua Powell, Laurel Hall, Victor R. DeFilippis, Klaus Fruh, Martine Smit, David D. Schlaepfer, Jay A. Nelson, and Daniel N. Streblow

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Human Cytomegalovirus US28: A Functionally Selective Chemokine Binding Receptor, Jennifer Totonchy, Jay A. Nelson, and Daniel N. Streblow

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A Collection of Micrographs: Where Science and Art Meet, Vuk Uskoković

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Challenges for the Modern Science in its Descend Towards Nano Scale, Vuk Uskoković

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New Dosing Schedules of Dasatinib for CML and Adverse Event Management, Siu Fun Wong

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CD82 Endocytosis Reveals Cholesterol-Dependent Reorganization of Tetraspanin-Enriched Microdomains and Lipid Rafts, Congfeng Xu, Yanhui H. Zhang, Muthusamy Thangavel, Mekel M. Richardson, Lu Liu, Bin Zhou, Yi Zheng, Rennolds S. Ostrom, and Xin A. Zhang

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The Complete Genome of Teredinibacter turnerae T7901: An Intracellular Endosymbiont of Marine Wood-Boring Bivalves (Shipworms), Joyce C. Yang, Ramana Madapu, A. Scott Durkin, Nathan A. Ekborg, Chandra S. Pedamallu, Jessica B. Hostetler, Diana Radune, Bradley S. Toms, Bernard Henrissat, Pedro M. Coutinho, Sandra Schwarz, Lauren Field, Amaro E. Trindade-Silva, Carlos A. G. Soares, Sherif Elshahawi, Amro Hanora, Eric W. Schmidt, Martha G. Haygood, Joanos Posfai, Jack Benner, Catherine Madinger, John Nove, Brian Anton, Kshitiz Chaudhary, Jeremy Foster, Alex Holman, Sanjay Kumar, Philip A. Lessard, Yvette A. Luyten, Barton Slatko, Nicole Wood, Bo Wu, Max Teplitski, Joseph D. Mougous, Naomi Ward, Jonathan A. Eisen, Jonathan H. Badger, and Daniel L. Distel

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Synthesis and Evaluation of Phosphopeptides Containing Iminodiacetate Groups as Binding Ligands of the Src SH2 Domain, Guofeng Ye, Aaron D. Schuler, Yousef Ahmadibeni, Joel R. Morgan, Absar Faruqui, Kezhen Huang, Gongqin Sun, John A. Zebala, and Keykavous Parang

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Pharmacodynamic Activity of Ceftobiprole Compared with Vancomycin versus Methicillin-Resistant Staphylococcus aureus (MRSA), Vancomycin-Intermediate Staphylococcus aureus (VISA) and Vancomycin-Resistant Staphylococcus aureus (VRSA) Using an In Vitro Model, George G. Zhanel, Dylan Voth, Kim Nichol, James A. Karlowsky, Ayman M. Noreddin, and Daryl J. Hoban

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Liquid Chromatography-Tandem Mass Spectrometry for the Determination of Methylprednisolone in Rat Plasma and Liver After Intravenous Administration of Its Liver-Targeted Dextran Prodrug, Shuang-Qing Zhang, Helen R. Thorsheim, Suman Penugonda, Venkateswaran C. Pillai, Quentin R. Smith, and Reza Mehvar

Submissions from 2008

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Symmetrical Dinucleosides, Yousef Ahmadibeni and Keykavous Parang

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Helical Peptides Derived from Lactoferrin Bind Hepatitis C Virus Envelope Protein E2, Reem Beleid, Donna Douglas, Norman Kneteman, and Kamaljit Kaur

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Zoledronic Acid Markedly Improves Bone Mineral Density for Patients with Monoclonal Gammopathy of Undetermined Significance and Bone Loss, James R. Berenson, Ori Yellin, Ralph V. Boccia, Marshall Flam, Siu Fun Wong, Olcay Batuman, Mehdi M. Moezi, Donald Woytowitz, Herbert Duvivier, Youram Nassir, and Regina A. Swift

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A High-Throughput In Vitro Model Illustrating Potential Microbiologocal Interactions During Treatment of Pseudomonas aeroginosa Biofilm Associated Infections, Walid Elkhatib, Virginia Haynes, and Ayman M. Noreddin

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Right-handed 14-Helix in β3-Peptides from L-Aspartic Acid Monomers, Kamaljit Kaur, Tara Sprules, Wael Soliman, Reem Beleid, and Sahar Ahmed

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Ciliary Dysfunction in Polycystic Kidney Disease: An Emerging Model with Polarizing Potential, Robert J. Kolb and Surya M. Nauli

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Fibroblast-Specific Expression of Adenylyl Cyclase 6 Reduces Myofibroblast Differentiation and Protects Against Bleomycin-Induced Pulmonary Fibrosis, Xiaoqiu Liu, Fengying Li, and Rennolds S. Ostrom

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Adenylyl Cyclase Type 6 Overexpression Selectively Enhances ß-Adrenergic and Prostacyclin Receptor Mediated Inhibition of Rat Cardiac Fibroblast Function Due to Co-Localization in Lipid Rafts, Xiaoqiu Liu, Muthusamy Thangavel, Shu Qiang Sun, Joseph Kaminsky, Penden Mahautmr, Jeremiah Stitham, John Hwa, and Rennolds S. Ostrom

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Endothelial Cilia Are Fluid Shear Sensors That Regulate Calcium Signaling and Nitric Oxide Production Through Polycystin-1, Surya M. Nauli, Yoshifumi Kawanabe, John J. Kaminski, William J. Pearce, Donald E. Ingber, and Jing Zhou

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An Orphan GCPR Finds a Home in the Heart. Focus On “Myocardial Expression, Signaling and Function of GPR22; a Protective Role for an Orphan G Protein-Coupled Receptor”, Hemal H. Patel and Rennolds S. Ostrom

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Synthesis and In Vitro Characterization of Novel Dextran- Methylprednisolone Conjugates with Peptide Linkers: Effects of Linker Length on Hydrolytic and Enzymatic Release of Methylprednisolone and Its Peptidyl Intermediates, Suman Penugonda, Anil Kumar, Hitesh K. Agarwal, Keykavous Parang, and Reza Mehvar

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Assessing the Efficiency of Hospital Pharmacy Services in Thai Public District Hospitals, Thananan Rattanachotphanit, Chulaporn Limwattananon, Supon Limwattananon, Jeff R. Johns, Jon C. Schommer, and Lawrence M. Brown

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Work Profiles Identified from the 2007 Pharmacist and Pharmaceutical Scientist Career Pathway Profile Survey, Jon C. Schommer, Lawrence M. Brown, and Elliott M. Sogol

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Drug Selection and Adverse Drug Reactions: Balancing Outcomes and Costs, Enrique Seoane-Vazquez

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Incentives for Orphan Drug Research and Development in the United States, Enrique Seoane-Vazquez, Rosa Rodriguez-Monguio, Sheryl L. Szeinbach, and Jay Visaria

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Proteomic Analysis Detects Cytoskeletal-Related Proteins That Interact With the Intracellular C1 Domain of Adenylyl Cyclase 6, Muthusamy Thangavel, Xiaoqiu Liu, and Rennolds S. Ostrom

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Composites Comprising Cholesterol and Carboxymethyl Cellulose, Vuk Uskoković

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Insights into Morphological Nature of Precipitation of Cholesterol, Vuk Uskoković

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Nanomaterials and Nanotechnologies: Approaching the Crest of this Big Wave, Vuk Uskoković

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Surface Charge Effects Involved in the Control of Stability of Sols Comprising Uniform Cholesterol Particles, Vuk Uskoković

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Enzymatic Processing of Amelogenin during Continuous Crystallization of Apatite, Vuk Uskoković, M.-K. Kim, W. Li, and S. Habelitz

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PDGF-Driven Proliferation, Migration, and IL8 Chemokine Secretion in Human Corneal Fibroblasts Involve JAK2-STAT3 Signaling Pathway, Neeraj Vij, Ajay Sharma, Mahesh Thakkar, Sunilima Sinha, and Rajiv R. Mohan

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Apurinic/Apyrimidinic Endonuclease/Redox Effector Factor-1(APE/Ref-1): A Unique Target for the Prevention and Treatment of Human Melanoma, Sun Yang and Frank L. Meyskens

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Nitric Oxide Initiates Progression of Human Melanoma via a Feedback Loop Mediated by Apurinic/Apyrimidinic Endonuclease-1/redox Factor-1, Which is Inhibited by Resveratrol, Zhen Yang, Sun Yang, Bobbye J. Misner, Rita Chiu, Feng Liu, and Frank L. Meyskens Jr.

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Pharmacodynamic Activity of Ertapenem versus Multidrug-Resistant Genotypically Characterized Extended-Spectrum Beta-Lactamase-Producing Escherichia coli Using an In Vitro Model, George G. Zhanel, Patricia Baudry, Vibhu Vashisht, Nancy Laing, Ayman M. Noreddin, and Daryl J. Hoban

Submissions from 2007

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Protein Pyrophosphorylation by Inositol Pyrophosphates is a Posttranslational Event, Rashna Bhandari, Adolfo Saiardi, Yousef Ahmadibeni, Adele M. Snowman, Adam C. Resnick, Troels Z. Kristiansen, Henrik Molina, Akhilesh Pandey, J. Kent Werner Jr., Krishna R. Juluri, Yong Xu, Glenn D. Prestwich, Keykavous Parang, and Solomon H. Snyder

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Synthesis And Antifungal Properties Of Alpha-Methoxy And Alpha-Hydroxyl Substituted 4-Thiatetradecanoic Acids, Nestor Carballeira, Rosann O'Neill, and Keykavous Parang

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Effects of Methylprednisolone and Its Liver-Targeted Dextran Prodrug on Ischemia–Reperfusion Injury in a Rat Liver Transplantation Model, Anjaneya Chimalakonda and Reza Mehvar

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Antagonism of p66shc by Melanoma Inhibitory Activity, K. Kasuno, A. Naqvi, J. DeRicco, T. Yamamori, L. Santhanam, I. Mattagajasingh, Sun Yang, F. L. Meyskens, A.-K. Bosserhoff, and K. Irani

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Improving Medication Safety in the ICU: The Pharmacist’s Role, Audrey J. Lee, Teresa B. Chiao, Jerika T. Lam, Shamima Khan, and Maureen S. Boro

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Expression and Localization of Adenylyl Cyclases and G Protein Receptors in Guinea Pig Ileum Caveolae and Lipid Rafts, Richard Reece, Xiaoqiu Liu, Shu Q. Sun, Frederick J. Ehlert, and Rennolds S. Ostrom

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The Proximal Segments of the Cytosolic Domain of Adenylyl Cyclase Type 6 Localize to Plasma Membrane Lipid Rafts and Caveolae, Muthusamy Thangavel, Xiaoqiu Liu, and Rennolds S. Ostrom

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Four Novel Co-Precipitation Procedures for the Synthesis of Lanthanum-Strontium Manganites, Vuk Uskoković and Miha Drofenik

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Uniform Particles of Pure and Silica Coated Cholesterol, Vuk Uskoković and Egon Matijević

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Drug Utilization and Cost in a Medicaid Population: A Simulation Study of Community vs. Mail Order Pharmacy, Satish Valluri, Enrique Seoane-Vazquez, Rosa Rodriguez-Monguio, and Sheryl L. Szeinbach

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Fibrocystin/Polyductin, Found in the Same Protein Complex with Polycystin-2, Regulates Calcium Responses in Kidney Epithelia, Shizuan Wang, Jingjing Zhang, Surya M. Nauli, Xiaogang Li, Patrick G. Starremans, Ying Luo, Kristina A. Roberts, and Jing Zhou

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Redox Effector Factor-1, Combined with Reactive Oxygen Species, Plays an Important Role in the Transformation of JB6 Cells, Sun Yang, Bobbye J. Misner, Rita J. Chiu, and Frank L. Meyskens Jr.

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Common and Distinct Mechanisms of Different Redox-Active Carcinogens Involved in the Transformation of Mouse JB6P+ Cells, Sun Yang, Bobbye J. Misner, Rita Chiu, and Frank L. Meyskens Jr.

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Synthesis and Evaluation of Tripodal Peptide Analogues for Cellular Delivery of Phosphopeptides, Guofeng Ye, Nguyen Hai Nam, Anil Kumar, Ali Saleh, Dinesh B. Shenoy, Mansoor M. Amiji, Xiaofeng Lin, Gongqin Sun, and Keykavous Parang

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Pharmacodynamic Activity of Ertapenem versus Penicillin-Susceptible and Penicillin-Non-Susceptible Streptococcus pneumoniae Using an In Vitro Model, George G. Zhanel, Sheldon Derkatch, Nancy Laing, Ayman M. Noreddin, and Daryl J. Hoban

Submissions from 2006

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The Science of Prevention Strategies, Rachel Abrishami and Jeffery A. Goad

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2,6-Hexadecadiynoic Acid and 2,6-Nonadecadiynoic Acid - Novel Synthesized Acetylenic Fatty Acids as Potent Antifungal Agents, Nestor Carballeira, David Sanabria, Clarisa Cruz, Keykavous Parang, Baojie Wan, and Scott Franzblau

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Attenuation of Acute Rejection in a Rat Liver Transplantation Model by a Liver-Targeted Dextran Prodrug of Methylprednisolone, Anjaneya Chimalakonda, Donald L. Montgomery, Jon A. Weidanz, Imam H. Shaik, Justin H. Nguyen, John J. Lemasters, Eiji Kobayashi, and Reza Mehvar

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Immunization Update, Karl M. Hess and Jeffery A. Goad

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Synthesis of Polymer-Bound 4-acetoxy-3-phenylbenzaldehyde Derivatives: Applications in Solid-Phase Organic Synthesis, Anil Kumar, Guofeng Ye, Yousef Ahmadibeni, and Keykavous Parang

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Synthesis and Structure-Activity Relationships of Linear and Conformationally Constrained Peptide Analogues of CIYKYY as Src Tyrosine Kinase Inhibitors, Anil Kumar, Guofeng Ye, Yuehao Wang, Xiaofeng Lin, Gongqin Sun, and Keykavous Parang

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Cost Prevention of HIV, Jerika Lam

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cAMP Inhibits TGF-ß-Stimulated Collagen Synthesis via Inhibition of ERK1/2 and SMAD Signaling in Rat Cardiac Fibroblasts, Xiaoqiu Liu, Shu Qiang Sun, Avi Hassid, and Rennolds S. Ostrom

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Palmitoylation at Cys 1145 in the Carboxyl Terminus of Human Type 6 Adenylyl Cyclase is Not Required for Targeting to Lipid Rafts and Caveolae, Xiaoqiu Liu, Shu Qiang Sun, and Rennolds S. Ostrom

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TGFß Signaling via ERK1/2 and Smad is Inhibited by cAMP-Elevating Agents in Rat Cardiac Fibroblasts, Xiaoqiu Liu, Shu Qiang Sun, and Rennolds S. Ostrom

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Estimation of Pharmacokinetic Parameters Based on the Patient-Adjusted Population Data, Reza Mehvar

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Interdependency of Pharmacokinetic Parameters: A Chicken-and-Egg Problem? Not!, Reza Mehvar

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Insights into the Effects of Hyperlipoproteinemia on Cyclosporine A Biodistribution and Relationship to Renal Function, Hamidreza Montazeri Aliabadi, Tara J. Spencer, Parvin Mahdipoor, Afsaneh Lavasanifar, and Dion R. Brocks

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Loss of Polycystin-1 in Human Cyst-Lining Epithelia Leads to Ciliary Dysfunction, Surya M. Nauli, Sandro Rossetti, Robert J. Kolb, Francis J. Alenghat, Mark B. Consugar, Peter C. Harris, Donald E. Ingber, Mahmoud Loghman-Adham, and Jing Zhou

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Stromal Haze, Myofibroblasts, and Surface Irregularity after PRK, Marcelo V. Netto, Rajiv R. Mohan, Sunilima Sinha, Ajay Sharma, William Dupps, and Steven E. Wilson

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Effect of Prophylactic and Therapeutic Mitomycin C on Corneal Apoptosis, Cellular Proliferation, Haze, and Long-Term Keratocyte Density in Rabbits, Marcelo V. Netto, Rajiv R. Mohan, Sunilima Sinha, Ajay Sharma, Pankaj C. Gupta, and Steven E. Wilson

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Caveolin-2, Rennolds S. Ostrom

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Methods for the Study of Signaling Molecules in Membrane Lipid Rafts and Caveolae, Rennolds S. Ostrom and Paul A. Insel

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Rapid Determination of Reduced and Oxidized Glutathione Levels Using a New Thiol-Masking Reagent and the Enzymatic Recycling Method: Application to the Rat Liver and Bile Samples, Imam H. Shaik and Reza Mehvar

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Mechanism of a Solid-State Formation of La1-xSrxMnO3+δ (0 < x < 0.5) and Magnetic Characterization Thereof, Vuk Uskoković and Miha Drofenik

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Synthesis of Lanthanum-Strontium Manganites by Oxalate-Precursor Co-Precipitation Methods in Solution and in Reverse Micellar Microemulsion, Vuk Uskoković and Miha Drofenik

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Preparation of Silica-Coated Lanthanum-Strontium Manganite Particles with Designable Curie Point, for Application in Hyperthermia Treatments, Vuk Uskoković, Aljoša Košak, and Miha Drofenik

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Silica-Coated Lanthanum-Strontium Manganites for Hyperthermia Treatments, Vuk Uskoković, Aljoša Košak, and Miha Drofenik

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Selective Effects of Nitric Oxide on the Disposition of Chlorzoxazone and Dextromethorphan in Isolated Perfused Rat Livers, Ragini Vuppugalla and Reza Mehvar

Submissions from 2005

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Fibrotic Lung Fibroblasts Show Blunted Inhibition by cAMP Due to Deficient cAMP Response Element-Binding Protein Phosphorylation, Xiaoqiu Liu, Shu Qiang Sun, and Rennolds S. Ostrom

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Redox Regulation by Intrinsic Species and Extrinsic Nutrients in Normal and Cancer Cells, Archana Jaiswal McEligot, Sun Yang, and Frank L. Meyskens Jr.

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Role of Protein Binding in Pharmacokinetics, Reza Mehvar

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Mouse Cytomegalovirus M33 is Necessary and Sufficient in Virus-Induced Vascular Smooth Muscle Cell Migration, Ryan Melnychuk, Patsy Smith, Craig N. Kreklywich, Franziska Ruchti, Jennifer Totonchy, Laurel Hall, Lambert Loh, Jay A. Nelson, Susan L. Orloff, and Daniel N. Streblow

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Chronic Hypoxia Modulates Relations Among Calcium, Myosin Light Chain Phosphorylation, and Force Differently in Fetal and Adult Ovine Basilar Arteries, Surya M. Nauli, James M. Williams, William T. Gerthoffer, and William J. Pearce

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Caveolins Muscle Their Way Into the Regulation of Cell Differentiation, Development and Function. Focus On “Muscle-Specific Interaction of Caveolin Isoforms (Cav-1, Cav-2 and Cav-3): Differential Complex Formation Between Caveolins in Fibroblastic Versus Muscle Cells", Rennolds S. Ostrom

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A Mechanism for the Formation of Nanostructured NiZn Ferrites via a Microemulsion-Assisted Precipitation Method, Vuk Uskoković and Miha Drofenik

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Synthesis of Relatively Highly Magnetic Nano-Sized NiZn-Ferrite in Microemulsion at 45 oC, Vuk Uskoković and Miha Drofenik

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Synthesis of Lanthanum-Strontium Magnanites by a Hydroxide-Precursor Co-Precipitation Method in Solution and in Reverse Micellar Microemulsion, Vuk Uskoković, Darko Makovec, and Miha Drofenik

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Enzyme-Selective Effects of Nitric Oxide on Affinity and Maximum Velocity of Various Rat Cytochromes P450, Ragini Vuppugalla and Reza Mehvar