Document Type
Article
Publication Date
12-8-2017
Abstract
Introduction
In October 2010, the US Food and Drug Administration (FDA) issued a safety communication regarding the risks of atypical fractures of the femur, with bisphosphonates drugs. This study evaluated the impact of the bisphosphonates FDA safety communication on the utilization of osteoporosis medications in Medicaid programs.
Methods
Osteoporosis drugs utilization data from the July 2006 to June 2014 were extracted from the national Summary Files from the Medicaid State Drug Utilization Data maintained by the Centers for Medicare & Medicaid Services (CMS). We performed an interrupted time series analyses to evaluate trends in utilization of osteoporosis drugs before and after the 2010 FDA safety commination.
Results
Time-series analyses of osteoporosis drug utilization in Medicaid program revealed a significant downward trend associated with the 2010 FDA bisphosphonates safety communication. Before the FDA safety communication was issued, the utilization rate was slightly decreased between 2006 and 2010. In the year following the FDA safety communication the bisphosphonate DDDs per 1000 beneficiaries of fell 22% yearly until the end of study period.
Conclusions
The 2010 FDA bisphosphonates safety communication appeared to have influenced Osteoporosis utilization in Medicaid recipients. The 2010 FDA bisphosphonates safety communication was associated with a significant reduction in the utilization of bisphosphonates in the Medicaid program.
Recommended Citation
Balkhi, B., Seoane-Vazquez, E., Rodriguez-Monguio, R., Changes in the Utilization of Osteoporosis Drugs after the 2010 FDA Bisphosphonate Drug Safety Communication, Saudi Pharmaceutical Journal (2017), doi: https://doi.org/10.1016/j.jsps.2017.12.005
Copyright
Elsevier
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Included in
Health and Medical Administration Commons, Health Communication Commons, Musculoskeletal, Neural, and Ocular Physiology Commons, Other Chemicals and Drugs Commons, Other Pharmacy and Pharmaceutical Sciences Commons, Pharmaceutical Preparations Commons, Pharmacy Administration, Policy and Regulation Commons
Comments
NOTICE: this is the author’s version of a work that was accepted for publication in Saudi Pharmaceutical Journal. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version will be subsequently published in Saudi Pharmaceutical Journal in 2017. DOI: 10.1016/j.jsps.2017.12.005