Pharmacological Approaches For the Management of Patients with Moderately Elevated Triglycerides (150-499 mg/dL)

Authors

Michael S. Kelly, Chapman UniversityFollow
Craig Beavers, University of Kentucky
John D. Bucheit, Virginia Commonwealth University
Evan M. Sisson, Virginia Commonwealth University
Dave L. Dixon, Virginia Commonwealth University

Document Type

Article

Publication Date

6-6-2017

Abstract

Hypertriglyceridemia, defined as serum triglyceride (TG) levels > 150 mg/dL, now affects over one-quarter of the U.S. adult population and is associated with an increased risk of atherosclerotic cardiovascular disease. Available guidelines for managing hypertriglyceridemia vary with respect to triglyceride thresholds and severity of disease. Lifestyle modifications and management of secondary causes (e.g., diabetes) remain the first step in managing hypertriglyceridemia, with pharmacotherapy reserved to reduce the risk of pancreatitis and/or further reduce TG levels. Several classes of lipid-lowering agents are available with variable TG-lowering efficacy. While there is no consensus regarding the choice of initial TG-lowering pharmacotherapy, there is general agreement that the decision depends on the degree of hypertriglyceridemia and atherosclerotic cardiovascular disease risk. This review will discuss available and emerging lipid-lowering therapies for the management of moderately elevated TG, defined as TG 150-499 mg/dL.

Comments

NOTICE: this is the author’s version of a work that was accepted for publication in Journal of Clinical Lipidology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version will be subsequently published in Journal of Clinical Lipidology in 2017. DOI: 10.1016/j.jacl.2017.05.014

The Creative Commons license below applies only to this version of the article.

Recommended Citation

Kelly MS, Beavers C, Bucheit JD, Sisson EM, Dixon DL. Pharmacological approaches for the management of patients with moderately elevated triglycerides (150-499 mg/dL). J Clin Lipidol. 2017. https://doi.org/10.1016/j.jacl.2017.05.014

Copyright

Elsevier

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.