Below you may find selected research articles from faculty in the School of Pharmacy.

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Submissions from 2024

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Perceptions of Metabolic Syndrome Management Utilization in Relation to Patient Experience and Health-related Quality of Life, Olajide Adekunle, Jon C. Schommer, Yun Wang, Ismaeel Yunusa, Marc L. Fleming, Enrique Seoane-Vazquez, and Lawrence M. Brown

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Proteomic Characterization and Cytotoxic Potential of Proteins from Cuscuta (Cuscuta epithymum (L.) Crude Herbal Product Against MCF-7 Human Breast Cancer Cell Line, Umaima Akhtar, Yamna Khurshid, Bishoy El-Aarag, Basir Syed, Ishtiaq A. Khan, Keykavous Parang, and Aftab Ahmed

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Modifying Peptide/Lipid-Associated Nucleic Acids (PLANAs) for CRISPR/Cas9 Ribonucleoprotein Delivery, Abdulelah Alhazza, Parvin Mahdipoor, Ryley Hall, Arthur Manda, Sandeep Lohan, Keykavous Parang, and Hamidreza Montazeri Aliabadi

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Real-Time cAMP Dynamics in Live Cells Using the Fluorescent cAMP Difference Detector In Situ, Isabella Cattani-Cavalieri, Jordyn Margolis, Camelia Anicolaesei, Francisco J. Nuñez, and Rennolds S. Ostrom

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Harnessing Exosomes as a Platform for Drug Delivery in Breast Cancer: A Systematic Review for in vivo and in vitro Studies, Abdulwahab Teflischi Gharavi, Saeed Irian, Azadeh Niknejad, Keykavous Parang, and Mona Salimi

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A Novel Micropeptide, Slitharin, Exerts Cardioprotective Effects in Myocardial Infarction, Ahmed G. E. Ibrahim, Alessandra Ciullo, Shukuro Yamaguchi, Chang Li, Travis Antes, Xaviar Jones, Liang Li, Ramachandran Murali, Innokentiy Maslennikov, Niveda Sundararaman, Daniel Soetkamp, Eugenio Cingolani, Jennifer Van Eyk, and Eduardo Marbán

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Modulation of Hippocampal Protein Expression by a Brain Penetrant Biologic TNF-α Inhibitor in the 3xTg Alzheimer’s Disease Mice, Nataraj Jagadeesan, G. Chuli Roules, Devaraj V. Chandrashekar, Joshua Yang, Sanjana Kolluru, and Rachita K. Sumbria

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Effectiveness of Empiric Carbapenem versus Non-carbapenem Therapy for Extended-spectrum β-lactamase Producing Enterobacterales Infections in Non-intensive Care Unit Patients: A Real-world Investigation in a Hospital with High-prevalence of Extended-spectrum β-lactamase Producing Enterobacterales, Amy Y. Kang, Mary Elkomos, Danny Pham, Michelle Guerrero, Deborah Kupferwasser, and Loren G. Miller

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Limonene Exerts Anti-Inflammatory Effect on LPS-Induced Jejunal Injury in Mice by Inhibiting NF-κB/AP-1 Pathway, Sarmed H. Kathem, Yasameen Sh. Nasrawi, Shihab H. Mutlag, and Surya M. Nauli

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Predisposing Deleterious Variants in the Cancer-Associated Human Kinases in the Global Populations, Salman Ahmed Khan, Misbah Anwar, Atia Gohar, Moom R. Roosan, Daniel C. Hoessli, Ambrina Khatoon, and Muhammad Shakeel

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Exploring LGBTQ+ Cultural Competency and DEI in Continuing Education: A Cross-sectional Review of U.S. Pharmacy Legislation, Jennifer Ko, Jeremy Carlos, and Yvonne Nguyen

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Pediatric Obesity in the United States: Age–Period–Cohort Analysis, Ashley W. Kranjac, Dinko Kranjac, and Roxanne I. Aguilera

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Broad-spectrum Activity of Membranolytic Cationic Macrocyclic Peptides Against Multi-drug Resistant Bacteria and Fungi, Sandeep Lohan, Anastasia G. Konshina, Rakesh K. Tiwari, Roman G. Efremov, Innokentiy Maslennikov, and Keykavous Parang

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Wilms’ Tumor 1 (WT1) Antigen is Overexpressed in Kaposi Sarcoma and is Regulated by KSHV vFLIP, Ayana E. Morales, Ruby Gumenick, Caitlin M. Genovese, Yun Yeong Jang, Ariene Ouedraogo, Maite Ibáñez de Garayo, Tania Pannellini, Sanjay Patel, Matthew E. Bott, Julio Alvarez, Sung Soo Mun, Jennifer Totonchy, Archana Gautam, Jesus Delgado de la Mora, Stephanie Chang, Dagmar Wirth, Marcelo Horenstein, Tao Dao, David A. Scheinberg, Paul G. Rubinstein, Aggrey Semeere, Jeffrey Martin, Catherine C. Godfrey, Carlee B. Moser, Roy M. Matining, Thomas B. Campbell, Margaret Z. Borok, Susan E. Krown, and Ethel Cesarman

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Oxidative Stress and Ion Channels in Neurodegenerative Diseases, Razan Orfali, Adnan Z. Alwatban, Rawan S. Orfali, Liz Lau, Noble Chea, Abdullah M. Alotaibi, Young-Woo Nam, and Miao Zhang

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Changes in Real-world Dispensing of ADHD Stimulants in Youth from 2019 to 2021 in California, Anika Patel, Rishikesh Chavan, Cyril Rakovski, Richard C. Beuttler, and Sun Yang

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Non-alcoholic Fatty Liver Disease: Role of PNPLA3 and Its Association with Environmental Chemicals, Shakil A. Saghir, Ata Abbas, Saleh Alfuraih, Ajay Sharma, Jean Latimer, Yadollah Omidi, and Rais Ansari

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Analysis of US Food and Drug Administration New Drug and Biologic Approvals, Regulatory Pathways, and Review Times, 1980–2022, Enrique Seoane-Vazquez, Rosa Rodriguez-Monguio, and John H. Powers III

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A Deep Learning-Based Theoretical Protocol to Identify Potentially Isoform-Selective PI3Kα Inhibitors, Muhammad Shafiq, Zaid Anis Sherwani, Mamona Mushtaq, Mohammad Nur-e-Alam, Aftab Ahmed, and Zaheer Ul-Haq

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Predicting FFAR4 Agonists Using Structure-Based Machine Learning Approach Based on Molecular Fingerprints, Zaid Anis Sherwani, Syeda Sumayya Tariq, Mamona Mushtaq, Ali Raza Siddiqui, Mohammad Nur-e-Alam, Aftab Ahmed, and Zaheer Ul-Haq

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Real-World Dispensing of Buprenorphine in California During Prepandemic and Pandemic Periods, Yun Wang, Alexandre Chan, Richard Beuttler, Marc L. Fleming, Todd Schneberk, Michael Nichol, and Haibing Lu

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Characterizing Antibiotic Regimen Modification Behavior, Patient Characteristics, and Outcomes for Patients with Gram-Negative Bacterial Infections, A Retrospective Single-Center Study, Jason Yamaki, Mirna Mikhail, Richard Beuttler, Philip Robinson, Emre Yücel, and Alexandre H. Watanabe

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Repurposing of US-FDA-approved Drugs as Negative Modulators of Ubiquitin Specific Protease-7 (USP7), Seema Zadi, Sumaira Javaid, Atia-tul-Wahab, Humaira Zafar, Muhammad Awais, Innokentiy Maslennikov, and M. Iqbal Choudhary

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Taming the Cytokine Storm: Small Molecule Inhibitors Targeting IL-6/IL-6α Receptor, Komal Zia, Mohammad Nur-e-Alam, Aftab Ahmed, and Zaheer Ul-Haq

Submissions from 2023

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The Structural Characterization and Bioactivity Assessment of Nonspecific Lipid Transfer Protein 1 (nsLTP1) from Caraway (Carum carvi) Seeds, Taibah Aldakhil, Saud O. Alshammari, Bushra Siraj, Bishoy El-Aarag, Shamshad Zarina, David Salehi, and Aftab Ahmed

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Postgraduate Medical Trainees at a Ugandan University Perceive Their Clinical Learning Environment Positively but Differentially Despite Challenging Circumstances: A Cross-sectional Study, Paul E. Alele, Joshua Kiptoo, and Kathleen Hill-Besinque

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Promiscuous Enzymes for Residue-Specific Peptide and Protein Late-Stage Functionalization, Ashley K. Alexander and Sherif I. Elshahawi

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The Concise Guide to PHARMACOLOGY 2023/24: Enzymes, Stephen P. H. Alexander, Doriano Fabbro, Eamonn Kelly, Alistair Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, James A. Davies, Stephanie Annett, Detlan Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angela A. Izzo, Rennolds Ostrom, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes-Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, and Szu Shen Wong

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Disentangling the Cost of Orphan Drugs Marketed in the United States, Hana Althobaiti, Enrique Seoane-Vazquez, Lawrence B. Brown, Marc L. Fleming, and Rosa Rodriguez-Monguio

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Generation and Characterization of CYP2E1-Overexpressing HepG2 Cells to Study the Role of CYP2E1 in Hepatic Hypoxia-Reoxygenation Injury, Nouf Alwadei, Mamunur Rashid, Devaraj Venkatapura Chandrashekar, Simin Rahighi, Jennifer Totonchy, Ajay Sharma, and Reza Mehvar

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Structure-Guided Mutagenesis Reveals the Catalytic Residue that Controls the Regiospecificity of C6-Indole Prenyltransferases, Ahmed R. Aoun, Nagaraju Mupparapu, Diem N. Nguyen, Tae Ho Kim, Christopher M. Nguyen, Zhengfeiyue Pan, and Sherif I. Elshahawi

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Describing the Evidence Linking Interprofessional Education Interventions to Improving the Delivery of Safe and Effective Patient Care: A Scoping Review, Tamara Cadet, Joseph Cusimano, Shelley McKearney, Julie Honaker, Cynthia O'Neal, Reza Taheri, Virginia Uhley, Yingting Zhang, Margaret Dreker, and Judith S. Cohn

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Quantitative Phosphoproteomic Analysis Reveals Unique cAMP signaling Pools Emanating from AC2 and AC6 in Human Airway Smooth Muscle Cells, Isabella Cattani-Cavalieri, Yue Li, Jordyn Margolis, Amy S. Bogard, Moom R. Roosan, and Rennolds S. Ostrom

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Alcohol as a Modifiable Risk Factor for Alzheimer’s Disease—Evidence from Experimental Studies, Devaraj V. Chandrashekar, Ross A. Steinberg, Derick Han, and Rachita K. Sumbria

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Structural Features of Thyroglobulin Linked to Protein Trafficking, Cintia E. Citterio, Kookjoo Kim, Bhavana Rajesh, Kevin Pena, Oliver Biggs Clark, and Peter Arvan

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Structural Analysis and Activity Correlation of Amphiphilic Cyclic Antimicrobial Peptides Derived from the [W4R4] Scaffold, Shaima Ahmed El-Mowafi, Anastasia G. Konshina, Eman H. M. Mohammed, Nikolay A. Krylov, Roman G. Efremov, and Keykavous Parang

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Proteoglycan 4 (PRG4)/Lubricin and the Extracellular Matrix in Gout, Khaled A. Elsaid, Gregory D. Jay, Ru Liu-Bryan, and Robert Terkeltaub

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Pharmacy Student Involvement in Population Health Management of Statin Quality Measures, Neeloufar Fakourfar and Hindu Rao

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Chronic Kidney Disease Promotes Cerebral Microhemorrhage Formation, Chuo Fang, Wei Ling Lau, Jiahong Sun, Rudy Chang, Adrian Vallejo, Donghy Lee, Jihua Liu, Han Liu, Yu-Han Hung, Yitong Zhao, Annlia Paganini-Hill, Rachita K. Sumbria, David H. Cribbs, and Mark J. Fisher

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Positive Changes in Safety Perception Among Blacks with HIV and Comorbidities: Assessment of Social Determinants of Health During COVID‑19, Marc Fleming, Deidra Lee, Chukwuezugo Oranu, Jon C. Schommer, Jennifer M. Cocohoba, Jennifer Cooper, Crystal K. Hodge, Saharnaz Nedjat, and Kathleen Borgmann

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Not a Waste: Wastewater Surveillance to Enhance Public Health, Anna Gitter, Jeremiah Oghuan, Anuja Rajendra Godbole, Carlos A. Chavarria, Carlos Monserrat, Tao Hu, Yun Wang, Anthony W. Maresso, Blake M. Hanson, Kristina D. Mena, and Fuqing Wu

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Recommendations for Nonantidote Medications Needed in the Emergency Department During a Mass Casualty Incident, Haili Gregory, Raniah Aljadeed, Dharati Desai, Faisal Syed Minhaj, Andrew Posen, Megan A. Rech, Andrew P. Smith, Kyle Weant, Kimberly Won, and David Zimmerman

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Design, Synthesis, and Antiproliferative Activity of Benzopyran-4-One-Isoxazole Hybrid Compounds, Shilpi Gupta, Shang Eun Park, Saghar Mozaffari, Bishoy El-Aarag, Keykavous Parang, and Rakesh Kumar Tiwari

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Chemical Hypoxic Preconditioning Improves Survival and Proliferation of Mesenchymal Stem Cells, Kanwal Haneef, Asmat Salim, Zehra Hashim, Amber Ilyas, Basir Syed, Aftab Ahmed, and Shamshad Zarina

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Cyclic Peptides with Antifungal Properties Derived from Bacteria, Fungi, Plants, and Synthetic Sources, Naiera M. Helmy and Keykavous Parang

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Tolfenamic Acid Derivatives: A New Class of Transcriptional Modulators with Potential Therapeutic Applications for Alzheimer’s Disease and Related Disorders, Juanetta Hill, Karim E. Shalaby, Syed W. Bihaqi, Bothaina H. Alansi, Benjamin Barlock, Keykavous Parang, Richard Thompson, Khalid Ourarhni, and Nasser H. Zawia

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Additive Effects of Cyclic Peptide [R4W4] When Added Alongside Azithromycin and Rifampicin against Mycobacterium avium Infection, Melissa Kelley, Kayvan Sasaninia, Arbi Abnousian, Ali Badaoui, James Owens, Abrianna Beever, Nala Kachour, Rakesh Kumar Tiwari, and Vishwanath Venketaraman

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Assessing Perspectives of a Global Health Area of Concentration Within the PharmD Curriculum, Jennifer Ko, Lauren Jonkman, Vidya Balakrishna Sharma, Emily Liu, and Sharon E. Connor

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The Effectiveness of Pay-It-Forward in Addressing HPV Vaccine Delay and Increasing Uptake Among 15–18-Year-Old Adolescent Girls Compared to User-Paid Vaccination: A Study Protocol for a Two-Arm Randomized Controlled Trial in China, Yifan Li, Chuanyu Qin, Shengyue Qiu, Yu He, Linchuan Pang, Xiaolan Xu, Vivian Wan-Cheong Yim, Shenglan Tang, Heng Du, Wenfeng Gong, Fan Yang, Joseph D. Tucker, Weiming Tang, Yun Wang, Leesa Lin, Mark Jit, Wei Song, Chunrong Li, Jennifer Smith, Jing Li, and Dan Wu

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Predicting Suicidal and Self-Injurious Events in a Correctional Setting Using AI Algorithms on Unstructured Medical Notes and Structured Data, Hongxia Lu, Alex Barrett, Albert Pierce, Jianwei Zheng, Yun Wang, Chun Chiang, and Cyril Rakovski

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Geospatial Analysis of Opioid Dispensing Patterns in California: A 2021 Real-World Study, Hongxia Lu, Jianwei Zheng, and Yun Wang

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Modified Linear Peptides Effectively Silence STAT-3 in Breast Cancer and Ovarian Cancer Cell Lines, Dindyal Mandal, Sandeep Lohan, Muhammad Imran Sajid, Abdulelah Alhazza, Rakesh Kumar Tiwari, Keykavous Parang, and Hamidreza Montazeri Aliabadi

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Effects of Transition from Closed-Book to Open-Book Assessment on Students’ Scores in a Pharmacokinetics Course, Reza Mehvar and Richard Beuttler

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A Motivational Interviewing Intervention to Improve Adherence to ACEIs/ARBs among Nonadherent Older Adults with Comorbid Hypertension and Diabetes, Anjana Mohan, Zahra Majd, Michael L. Johnson, Ekere J. Essien, Jamie Barner, Omar Serna, Esteban Gallardo, Marc L. Fleming, Nancy Ordonez, Marcia M. Holstad, and Susan M. Abughosh

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Targeting Breast Cancer: The Familiar, the Emerging, and the Uncharted Territories, Hamidreza Montazeri Aliabadi, Arthur Manda, Riya Sidgal, and Co Chung

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Amphiphilic Cell-Penetrating Peptides Containing Arginine and Hydrophobic Residues as Protein Delivery Agents, Jonathan Moreno, Khalid Zoghebi, David Salehi, Lois Kim, Sorour Khayyatnejad Shoushtari, Rakesh K. Tiwari, and Keykavous Parang

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Sensing Behavior of Pristine and TM-decorated Zn12O12 Nanocage Towards Toxic Formaldehyde, Phosgene and Thiophosgene Gases, Sajida Munsif, Khurshid Ayub, Mohammad Nur-e-Alam, Sarfaraz Ahmed, Aftab Ahmed, and Zaheer Ul-Haq

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Identification of Potent Anti-immunogenic Agents Through Virtual Screening, 3D-QSAR Studies, and in vitro Experiments, Mamona Mushtaq, Saman Usmani, Almas Jabeen, Mohammad Nur-e-Alam, Sarfaraz Ahmed, Aftab Ahmed, and Zaheer Ul-Haq

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Loss-of-Function KCa2.2 Mutations Abolish Channel Activity, Young-Woo Nam, Mohammad Asikur Rahman, Grace Yang, Razan Orfali, Meng Cui, and Miao Zhang

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The Effects of Sex Hormones on the Size of Intestinal Lipoproteins, Andromeda M. Nauli, Ann Phan, Patrick Tso, and Surya M. Nauli

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Prorelaxant E-type Prostanoid Receptors Functionally Partition to Different Procontractile Receptors in Airway Smooth Muscle, Ajay P. Nayak, Elham Javed, Dominic R. Villaba, Yinna Wang, Henry P. Morelli, Sushrut D. Shah, Nicholas Kim, Rennolds S. Ostrom, Reynold A. Pannettieri Jr., Steven S. An, Dale D. Tang, and Raymond B. Penn

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Factors Affecting Initiation and Retention of Medication-Assisted Recovery (MAR) within a Pilot Pharmacist-Involved Practice Model at a Federally Qualified Healthcare Center (FQHC) during the COVID-19 Pandemic, Tiffany Nguyen, Thomas Craig Cheetham, Souhiela Fawaz, Richard Beuttler, and Sharon Xavioer

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KCa2 and KCa3.1 Channels in the Airways: A New Therapeutic Target, Razan Orfali, Ali AlFaiz, Mohammad Asikur Rahman, Liz Lau, Young-Woo Nam, and Miao Zhang

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Folate Conjugated Nanomedicines for Selective Inhibition of mTOR Signaling in Polycystic Kidneys at Clinically Relevant Doses, Rajasekharreddy Pala, Ayan K. Barui, Ashraf M. Mohieldin, Jing Zhou, and Surya M. Nauli

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Improving Pharmacist-Led Pediatric Patient Education on Oral Chemotherapy at Home, Anika Patel, Christopher M. Nguyen, Kristin Willins, Elsabella Y. Wang, Grace Magedman, and Sun Yang

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Development and Validation of an Ultrahigh-Performance Liquid Chromatography–Tandem Mass Spectrometry Method to Investigate the Plasma Pharmacokinetics of a KCa2.2/KCa2.3 Positive Allosteric Modulator in Mice, Mohammad Asikur Rahman, Devaraj Venkatapura Chandrashekar, Young-Woo Nam, Basir Syed, David Salehi, Hamidreza Montazeri Aliabadi, Miao Zhang, and Reza Mehvar

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Development and Validation of a UPLC-MS/MS Method to Investigate the Plasma Pharmacokinetics of a KCa2.2/KCa2.3 Positive Allosteric Modulator in Mice, Mohammad Asikur Rahman, Devaraj Venkatapura Chandrashekar, Young-Woo Nam, Basir Syed, David Salehi, Hamidreza Montazeri Aliabadi, Miao Zhang, and Reza Mehvar

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KCa2.2 (KCNN2): A Physiologically and Therapeutically Important Potassium Channel, Mohammad Asikur Rahman, Razan Orfali, Nikita Dave, Elyn Lam, Nadeen Naguib, Young-Woo Nam, and Miao Zhang

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A New Method for Investigating Bioequivalence of Inhaled Formulations: A Pilot Study on Salbutamol, Homa Razaei, Maryam Khoubnasabjafari, Vahid Jouyban-Gharamaleki, Hamed Hamishehkar, Mohammad Reza Afshar Mogaddam, Elaheh Rahimpour, Reza Mehvar, and Abolghasem Jouyban

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A Comparative Assessment of Approvals and Discontinuations of Systemic Antibiotics and Other Therapeutic Areas, Rosa Rodriguez-Monguio, Enrique Seoane-Vazquez, and John H. Powers III

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COVID-Dynamic: A Large-Scale Longitudinal Study of Socioemotional and Behavioral Change Across the Pandemic, Tessa Rusch, Yanting Han, Dehua Liang, Amber R. Hopkins, Carolyn V. Lawrence, Uri Maoz, Lynn K. Paul, Damian A. Stanley, and The COVID-Dynamic Team

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Untargeted Metabolomics Analysis on Kidney Tissues from Mice Reveals Potential Hypoxia Biomarkers, Muhammad Imran Sajid, Francisco J. Nunez, Farideh Amirrad, Moom Rahman Roosan, Tom Vojtko, Scott McCulloch, Amal Alachkar, and Surya M. Nauli

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Predicting Survival of NSCLC Patients Treated with Immune Checkpoint Inhibitors: Impact and Timing of Immune-related Adverse Events and Prior Tyrosine Kinase Inhibitor Therapy, Michael R. Sayer, Isa Mambetsariev, Kun-Han Lu, Chi Wah Wong, Ashley Duche, Richard Beuttler, Jeremy Fricke, Rebecca Pharaon, Leonidas Arvanitis, Zahra Eftekhari, Arya Amini, Marianna Koczywas, Erminia Massarelli, Moom Rahman Roosan, and Ravi Salgia

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Murine Models of Graft Versus Host Disease (GVHD): Focus on Ocular GVHD, Philipp Steven, Victor L. Perez, and Ajay Sharma

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Differential Protein Expression in Response to Varlitinib Treatment in Oral Cancer Cell Line: an In Vitro Therapeutic Approach, Fariha Tanveer, Amber Ilyas, Basir Syed, Zehra Hashim, Aftab Ahmed, and Shamshad Zarina

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Brain Microvascular Endothelial Cells Possess a Second Cilium That Arises from the Daughter Centriole, Karthikeyan Thirugnanam, Ankan Gupta, Francisco Nunez, Shubhangi Prabhudesai, Amy Y. Pan, Surya M. Nauli, and Ramani Ramchandran

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What Quantifies Good Primary Care in the United States? A Review of Algorithms and Metrics Using Real-World Data, Yun Wang, Jianwei Zheng, Todd Schneberk, Yu Ke, Alexandre Chan, Tao Hu, Jerika Lam, Mary Gutierrez, Ivan Portillo, Dan Wu, Chi-Hung Chang, Yang Qu, Lawrence Brown, and Michael B. Nichol

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A Critical Appraisal of the Physicochemical Properties and Biological Effects of Artificial Tear Ingredients and Formulations, Judy Weng, Michael K. Fink, and Ajay Sharma

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Diabetes-Associated Hyperglycemia Causes Rapid-Onset Ocular Surface Damage, Judy Weng, Christopher Ross, Jacob Baker, Saleh Alfuraih, Kiumars Shamloo, and Ajay Sharma

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Addressing the Crisis: Leveraging the United Nations Sustainable Development Goals to Prepare Student Leaders to Tackle the Opioid Epidemic, Sharon Xavioer, Laressa Bethishou, Madeline Dintzner, Reza Taheri, and Jelena Lewis

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The Effects of a Blood–Brain Barrier Penetrating Erythropoietin in a Mouse Model of Tauopathy, Joshua Yang, Weijun Ou, Nataraj Jagadeesan, Juste Simanauskaite, Jiahong Sun, Demi M. Castellanos, David H. Cribbs, and Rachita K. Sumbria

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Erythrocyte–Brain Endothelial Interactions Induce Microglial Responses and Cerebral Microhemorrhages in Vivo, Hai Zhang, Rachita K. Sumbria, Rudy Chang, Jiahong Sun, David H. Cribbs, Todd C. Holmes, Mark J. Fisher, and Xiangmin Xu

Submissions from 2022

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Synthesis and Biological Evaluation of 5′-O-Fatty Acyl Ester Derivatives of 3′-Fluoro-2′,3′-dideoxythymidine as Potential Anti-HIV Microbicides, Hitesh Agarwal, Bhupender S. Chhikara, Guofeng Ye, Sitaram Bhavaraju, Ajay Dixit, Anil Kumar, Gustavo F. Doncel, and Keykavous Parang

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Bis-Cinnamamide Derivatives as APE/Ref-1 Inhibitors for the Treatment of Human Melanoma, Razan Alhazmi, Shirley Tong, Shaban Darwish, Elina Khanjani, Bharti Khungar, Swati Chawla, Zhonghui Zheng, Richard Chamberlain, Keykavous Parang, and Sun Yang

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Host-Level Susceptibility and IRF1 Expression Influence the Ability of IFN-γ to Inhibit KSHV Infection in B Lymphocytes, Nedaa Alomari and Jennifer Totonchy

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IL-21 Signaling Promotes the Establishment of KSHV Infection in Human Tonsil Lymphocytes by Increasing Differentiation and Targeting of Plasma Cells, Nedaa Alomari and Jennifer Totonchy

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Differential Expression and Activities of Cytochrome P450 3A in the Rat Brain Microsomes and Mitochondria, Nouf Alshammari, Devaraj Venkatapura Chandrashekar, Mamunur Rashid, and Reza Mehvar

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The Use of Advanced Spectral Imaging to Reveal Nanoparticle Identity in Biological Samples, Qamar A. Alshammari, Rajasekharreddy Pala, Ayan K. Barui, Saud O. Alshammari, Andromeda M. Nauli, Nir Katzir, Ashraf M. Mohieldin, and Surya M. Nauli

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Cytotoxic Activity of Non-specific Lipid Transfer Protein (nsLTP1) from Ajwain (Trachyspermum ammi) Seeds, Saud O. Alshammari, Taibah Aldakhil, Qamar A. Alshammari, David Salehi, and Aftab Ahmed

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Hypertrophic and Fibrotic Human PKD Hearts are Associated with Macrophage Infiltration and Abnormal TGF-β1 Signaling, Farideh Amirrad, Gregory A. Fishbein, Robert A. Edwards, and Surya M. Nauli

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Targeted Next-Generation Sequencing of Congenital Hypothyroidism-causative Genes Reveals Unexpected Thyroglobulin Gene Variants in Patients with Iodide Transport Defect, Carlos Eduardo Bernal Barquero, Romina Celeste Geysels, Virginie Jacques, Gerardo Hérnan Carro, Mariano Martín, Victoria Peyret, María Celeste Abregú, Patricia Papendieck, Ana María Masini-Repiso, Frédérique Savagner, Ana Elena Chiesa, Cintia E. Citterio, and Juan Pablo Nicola

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Combinational Silencing of Components Involved in JAK/STAT Signaling Pathway, Emira Bousoik, Parvin Mahdipoor, Abdulelah Alhazza, and Hamidreza Montazeri Aliabadi

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Editorial: Adenylyl Cyclase Isoforms as Potential Drug Targets, Tarsis F. Brust, Rennolds S. Ostrom, and Val J. Watts

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Global Cancer Statistics 2022: The Trends Projection Analysis, Bhupender S. Chhikara and Keykavous Parang

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Nanotherapeutics and HIV: Four Decades of Infection Canvass the Quest for Drug Development Using Nanomedical Technologies, Bhupender S. Chhikara, Nirpendra Singh, Poonam, Parveen Bazard, Rajender S. Varma, and Keykavous Parang

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Clinical Application and Feasibility of Utilizing the PEDI-CAT to Assess Activity and Participation Among Children Receiving Physical Therapy Incorporating Hippotherapy, Susan Conroy, Trish Evans, Dana Butler-Moburg, Richard Beuttler, Janelle Robinson, Matt Huebert, Erin O. Mahoney, and Marybeth Grant-Beuttler

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Citizenship Matters: Non-Citizen COVID-19 Mortality Disparities in New York and Los Angeles, Jason A. Douglas, Georgiana Bostean, Angel Miles Nash, Emmanuel B. John, Lawrence M. Brown, and Andrew M. Subica

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Amplification of Inflammation by Lubricin Deficiency Implicated in Incident, Erosive Gout Independent of Hyperuricemia, Khaled A. Elsaid, Tony R. Merriman, Leigh-Ana Rossitto, Ru Liu-Bryan, Jacob Karsh, Amanda Phipps-Green, Gregory D. Jay, Sandy Elsayed, Marwa Qadri, Marin Miner, Murray Cadzow, Talia J. Dambruoso, Tannin A. Schmidt, Nicola Dalbeth, Ashika Chhana, Jennifer Höglund, Majid Ghassemian, Anaamika Campeau, Nancy Maltez, Niclas G. Karlsson, David J. Gonzalez, and Robert Terkeltaub

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Protein Phosphatase 2A Regulates Xanthine Oxidase-derived ROS Production in Macrophages and Influx of Inflammatory Monocytes in a Murine Gout Model, Sandy Elsayed and Khaled A. Elsaid

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We Need a Labeling System for Pharmaceutical Prices, Robin Feldman, Natalie Feldman, and Enrique Seoane-Vazquez