The Concise Guide to PHARMACOLOGY 2023/24: Enzymes

Authors

Stephen P. H. Alexander, University of Nottingham
Doriano Fabbro, PIQUR Therapeutics
Eamonn Kelly, University of Bristol
Alistair Mathie, University of Suffolk
John A. Peters, University of Dundee
Emma L. Veale, University of Suffolk
Jane F. Armstrong, University of Edinburgh
Elena Faccenda, University of Edinburgh
Simon D. Harding, University of Edinburgh
James A. Davies, University of Edinburgh
Stephanie Annett, Royal College of Surgeons Ireland
Detlan Boison, Rutgers University
Kathryn Elisa Burns, University of Auckland
Carmen Dessauer, University of Texas at Houston
Jürg Gertsch, University of Bern
Nuala Ann Helsby, University of Auckland
Angela A. Izzo, University of Naples
Rennolds Ostrom, Chapman UniversityFollow
Andreas Papapetropoulos, University of Athens
Nigel J. Pyne, University of Glasgow
Susan Pyne, University of Glasgow
Tracy Robson, Royal College of Surgeons Ireland
Roland Seifert, Hannover Medical School
Johannes-Peter Stasch, Bayer HealthCare
Csaba Szabo, University of Fribourg
Mario van der Stelt, Leiden University
Albert van der Vliet, University of Vermont
Val Watts, Purdue University
Szu Shen Wong, Keele University

Document Type

Article

Publication Date

12-20-2023

Abstract

The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.16176. In addition to this overview, in which are identified ‘Other protein targets’ which fall outside of the subsequent categorisation, there are six areas of focus: G protein-coupled receptors, ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

Comments

This article was originally published in British Journal of Pharmacology, volume 180, issue S2, in 2023. https://doi.org/10.1111/bph.16181

Recommended Citation

Alexander SPH, Fabbro D, Kelly E, et al. The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol, 180: S289–S373. 2023. https://doi.org/10.1111/bph.16181

Copyright

The authors

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.