Document Type
Article
Publication Date
1-28-2024
Abstract
Numerous neurodegenerative diseases result from altered ion channel function and mutations. The intracellular redox status can significantly alter the gating characteristics of ion channels. Abundant neurodegenerative diseases associated with oxidative stress have been documented, including Parkinson’s, Alzheimer’s, spinocerebellar ataxia, amyotrophic lateral sclerosis, and Huntington’s disease. Reactive oxygen and nitrogen species compounds trigger posttranslational alterations that target specific sites within the subunits responsible for channel assembly. These alterations include the adjustment of cysteine residues through redox reactions induced by reactive oxygen species (ROS), nitration, and S-nitrosylation assisted by nitric oxide of tyrosine residues through peroxynitrite. Several ion channels have been directly investigated for their functional responses to oxidizing agents and oxidative stress. This review primarily explores the relationship and potential links between oxidative stress and ion channels in neurodegenerative conditions, such as cerebellar ataxias and Parkinson’s disease. The potential correlation between oxidative stress and ion channels could hold promise for developing innovative therapies for common neurodegenerative diseases.
Recommended Citation
Orfali R, Alwatban AZ, Orfali RS, Lau L, Chea N, Alotaibi AM, Nam Y-W and Zhang M (2024), Oxidative stress and ion channels in neurodegenerative diseases. Front. Physiol. 15:1320086. https://doi.org/10.3389/fphys.2024.1320086
Copyright
The authors
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Included in
Cell Anatomy Commons, Cell Biology Commons, Cells Commons, Medicinal and Pharmaceutical Chemistry Commons, Nervous System Diseases Commons, Other Pharmacy and Pharmaceutical Sciences Commons
Comments
This article was originally published in Frontiers in Physiology, volume 15, in 2024. https://doi.org/10.3389/fphys.2024.1320086