At the Crossroad of Nucleotide Dynamics and Protein Synthesis in Bacteria

Authors

Lorenzo Eugenio Leiva, Chapman University
Victor Zegarra, Philipps-University Marburg
Gert Bange, Philipps-University Marburg
Michael Ibba, Chapman UniversityFollow

Document Type

Article

Publication Date

2-28-2023

Abstract

Nucleotides are at the heart of the most essential biological processes in the cell, be it as key protagonists in the dogma of molecular biology or by regulating multiple metabolic pathways. The dynamic nature of nucleotides, the cross talk between them, and their constant feedback to and from the cell’s metabolic state position them as a hallmark of adaption toward environmental and growth challenges. It has become increasingly clear how the activity of RNA polymerase, the synthesis and maintenance of tRNAs, mRNA translation at all stages, and the biogenesis and assembly of ribosomes are fine-tuned by the pools of intracellular nucleotides. With all aspects composing protein synthesis involved, the ribosome emerges as the molecular hub in which many of these nucleotides encounter each other and regulate the state of the cell. In this review, we aim to highlight intracellular nucleotides in bacteria as dynamic characters permanently cross talking with each other and ultimately regulating protein synthesis at various stages in which the ribosome is mainly the principal character.

Comments

This article was originally published in Microbiology and Molecular Biology Reviews, volume 87, issue 1, in 2023. https://doi.org/10.1128/mmbr.00044-22

Recommended Citation

Leiva LE, Zegarra V, Bange G, Ibba M. At the Crossroad of Nucleotide Dynamics and Protein Synthesis in Bacteria. Microbiol Mol Biol Rev. 2023;87(1):e0004422. https://doi.org/10.1128/mmbr.00044-22

Copyright

American Society for Microbiology