Non-genomic Effects of Glucocorticoids: An Updated View

Authors

Reynod A. Panettieri, Rutgers Institute for Translational Medicine & Science
Dedmer Schaafsma, Science Impact, Winnipeg
Yassine Amrani, Leicester Biomedical Research Center Respiratory
Cynthia Koziol-White, Rutgers Institute for Translational Medicine and Science
Rennolds S. Ostrom, Chapman UniversityFollow
Omar Tliba, Long Island University

Document Type

Article

Publication Date

11-26-2018

Abstract

Glucocorticoid (GC) anti-inflammatory effects generally require a prolonged onset of action and involve genomic processes. Because of the rapidity of some of the GC effects, however, the concept that non-genomic actions may contribute to GC mechanisms of action has arisen. While the mechanisms have not been completely elucidated, the non-genomic effects may play a role in the management of inflammatory diseases. For instance, we recently reported that GCs ‘rapidly’ enhanced the effects of bronchodilators, agents used in the treatment of allergic asthma. In this review article, we discuss (i) the non-genomic effects of GCs on pathways relevant to the pathogenesis of inflammatory diseases and (ii) the putative role of the membrane GC receptor. Since GC side effects are often considered to be generated through its genomic actions, understanding GC non-genomic effects will help design GCs with a better therapeutic index.

Comments

NOTICE: this is the author’s version of a work that was accepted for publication in Trends in Pharmacological Sciences. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Trends in Pharmacological Sciences, volume 40, issue 1, in 2019. DOI: 10.1016/j.tips.2018.11.002

The Creative Commons license below applies only to this version of the article.

Recommended Citation

Panettieri RA, Schaafsma D, Amrani Y, Koziol-White C, Ostrom R, Tliba O. Non-genomic effects of glucocorticoids: An updated view. Trends Pharmacol Sci. 2019;40(1):38-49. doi: 10.1016/j.tips.2018.11.002

Copyright

Elsevier

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.