Student Scholar Symposium Abstracts and Posters
Document Type
Poster
Publication Date
Spring 5-1-2024
Faculty Advisor(s)
Dr. Molla Islam
Abstract
Nanogels have emerged as a notably safer and more effective means for drug delivery, primarily due to their adjustable drug-loading capabilities. Hollow-core nanoparticles offer some unique properties that are desirable for drug delivery applications. Initially, silica core nanoparticles were synthesized using the Stöber process at different temperatures where Tetraethoxysilane (TEOS) undergoes hydrolysis in the presence of ethanol and then a condensation reaction to form silica nanoparticles. Scanning Electron Microscopy (SEM) and Optical Microscopy (OM) analysis revealed that the size of silica core particles varied with the synthesis temperature (300 nm at 30°C to 150 at 60°C). The core silica particles were first coated with 3-(Trimethoxysilyl)propyl methacrylate (MPS) layers and used as seeds to grow ultra-low-cross linked thermoresponsive poly(N-isopropyl acrylamide) (NIPAm) shells using surfactant-free emulsion polymerization reaction. SEM and OM (differential contrast Interference Contrast) confirmed the addition of the NIPAm shell. The core was dissolved to get hollow shell nanogels. These hollow shell nanogels are very good candidates for drug delivery applications due to the presence of a hollow compartment in their structures.
Recommended Citation
Hijazi, Mohamad and Islam, Molla R., "Synthesis of Thermoresponsive Poly(N-isopropyl acrylamide) Based Core-Shell and Hollow Shell Nanogel with Tunable Core and Shell Thickness" (2024). Student Scholar Symposium Abstracts and Posters. 645.
https://digitalcommons.chapman.edu/cusrd_abstracts/645
Included in
Medicinal and Pharmaceutical Chemistry Commons, Medicinal-Pharmaceutical Chemistry Commons, Other Pharmacy and Pharmaceutical Sciences Commons, Pharmaceutics and Drug Design Commons
Comments
Presented at the Spring 2024 Student Scholar Symposium at Chapman University.