Data from: A Selfish Genetic Element Linked to Increased Lifespan Impacts Metabolism in Female House Mice

Data from: A Selfish Genetic Element Linked to Increased Lifespan Impacts Metabolism in Female House Mice

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Description

Gene drive systems can lead to the evolution of traits that further enhance the transmission of the driving element. In gene drive, one allele is transmitted to offspring at a higher frequency than the homologous allele. This has a range of consequences, which generally include a reduction in fitness of the carrier of the driving allele, making such systems selfish. The t haplotype is one such driver, found in house mice. It is linked to a reduction in litter size in matings among heterozygous animals, but also to increased lifespan in wild females that carry it. Here, we tested whether carrying the t haplotype was associated with altered resting metabolic rate (RMR). We show that females carrying the t haplotype decrease RMR as they increase in size, compared to wildtype females or males of either genotype. Our study elucidates a plausible mechanism by which a selfish genetic element increases lifespan.

Publication Date

12-17-2019

Keywords

energetics, meiotic drive, Mus musculus

Disciplines

Animal Experimentation and Research | Genetics | Other Animal Sciences

Comments

Usage Notes

Resting metabolic rate data

This file contains the respirometer results run in the laboratory. Box is the respirometer box; ID is the animal identity; sex is the animal sex; haplotype is the haplotype of the animal (w for wildtype and t for t-haplotype); VO2_abs is the resting VO2 value; pair indicates the sibling pair that was compared (from same litter and run at the same time in respirometer); mean_bm constitutes the average of the body mass measurements at the beginning and end of the respirometry quantification.

LopesLindholmRMR.xlsx

Copyright

This work is licensed under a CC0 1.0 Universal (CC0 1.0) Public Domain Dedication license.

Data from: A Selfish Genetic Element Linked to Increased Lifespan Impacts Metabolism in Female House Mice

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