Mechanisms of Multiple Cellular Adaptation Processes in Clonal Cell Lines During Chronic Opiate Treatment

Authors

Ping-Yee Law, University of California - San Francisco
Michael T. Griffin, Chapman UniversityFollow
Horace H. Loh, University of California - San Francisco

Files

Description

Among the various in vitro models for studies of opiate action, the clonal cell line, neuroblastoma x glioma NG 108-15 hybrid cells, represents the simplest model of brain origin in which the molecular basis of opiate action is being investigated. The hybrid cells possess many neuronal properties, such as having excitable membrane containing light and dense core vesicles; also the hybrid cells can be synapsed onto striatal muscle cells (Hamprecht 1977).

Publication Date

1984

Publisher

National Institute on Drug Abuse

City

Rockville, MD

Keywords

Adaptation, Physiological, Narcotics pharmacology

Disciplines

Nervous System | Substance Abuse and Addiction

Comments

In __ (Ed.), Title of book. Dr. Griffin's chapter begins on page 119 (page 134 of the PDF).

Recommended Citation

Law, Ping-Yee, Michael T. Griffin, and Horace H. Loh. "Mechanisms of multiple cellular adaptation processes in clonal cell lines during chronic opiate treatment." Mechanisms of tolerance and dependence 54. Rockville, MD: National Institute on Drug Abuse, 1984 (pp. 119-135).

Copyright

The authors