Document Type
Article
Publication Date
8-18-2020
Abstract
Bacterial oxidative stress responses are generally controlled by transcription factors that modulate the synthesis of RNAs with the aid of some sRNAs that control the stability, and in some cases the translation, of specific mRNAs. Here, we report that oxidative stress additionally leads to inactivation of tRNAGly in Escherichia coli, inducing a series of physiological changes. The observed inactivation of tRNAGly correlated with altered efficiency of translation of Gly codons, suggesting a possible mechanism of translational control of gene expression under oxidative stress. Changes in translation also depended on the availability of glycine, revealing a mechanism whereby bacteria modulate the response to oxidative stress according to the prevailing metabolic state of the cells.
Recommended Citation
Leiva, L.E., Pincheira, A., Elgamal, S., Kienast, S.D., Bravo, V., Leufken, J., Gutierrez, D.V., Leidel, S.A., Ibba, M., and Katz, A. (2020) Modulation of Escherichia coli translation by the specific inactivation of tRNAGly under oxidative stress. Front. Genet. 11, e00856. https://doi.org/10.3389/fgene.2020.00856
Copyright
The authors
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Included in
Amino Acids, Peptides, and Proteins Commons, Biochemistry Commons, Cellular and Molecular Physiology Commons, Molecular Biology Commons, Nucleic Acids, Nucleotides, and Nucleosides Commons, Other Biochemistry, Biophysics, and Structural Biology Commons
Comments
This article was originally published in Frontiers in Genetics, volume 11, in 2020. https://doi.org/10.3389/fgene.2020.00856