Document Type
Article
Publication Date
9-16-2014
Abstract
During mRNA decoding at the ribosome, deviations from stringent codon identity, or “mistranslation,” are generally deleterious and infrequent. Observations of organisms that decode some codons ambiguously, and the discovery of a compensatory increase in mistranslation frequency to combat environmental stress have changed the way we view “errors” in decoding. Modern tools for the study of the frequency and phenotypic effects of mistranslation can provide quantitative and sensitive measurements of decoding errors that were previously inaccessible. Mistranslation with non‐protein amino acids, in particular, is an enticing prospect for new drug therapies and the study of molecular evolution.
Recommended Citation
Moghal, A., Mohler, K. and Ibba, M. (2014) Mistranslation of the genetic code. FEBS Letts. 588, 4305-4310. https://doi.org10.1016/j.febslet.2014.08.035
Copyright
Federation of European Biochemical Societies
Included in
Amino Acids, Peptides, and Proteins Commons, Biochemistry Commons, Cellular and Molecular Physiology Commons, Molecular Biology Commons, Nucleic Acids, Nucleotides, and Nucleosides Commons, Other Biochemistry, Biophysics, and Structural Biology Commons
Comments
This is a pre-copy-editing, author-produced PDF of an article accepted for publication in FEBS Letters, volume 588, in 2014 following peer review. The definitive publisher-authenticated version is available online at https://doi.org/10.1016/j.febslet.2014.08.035.