tRNA Recognition and Evolution of Determinants in Seryl-tRNA Synthesis

Authors

Boris Lenhard, University of Zagreb
Omar Orellana, Universidad de Chile
Michael Ibba, Chapman UniversityFollow
Ivana Weygand-Durasevic, University of Zagreb

Document Type

Article

Publication Date

2-1-1999

Abstract

We have analyzed the evolution of recognition of tRNAs^Ser by seryl-tRNA synthetases, and compared it to other type 2 tRNAs, which contain a long extra arm. In Eubacteria and chloroplasts this type of tRNA is restricted to three families: tRNA^Leu, tRNA^Ser and tRNA^Tyr. tRNA^Leu and tRNA^Ser also carry a long extra arm in Archaea, Eukarya and all organelles with the exception of animal mitochondria. In contrast, the long extra arm of tRNA^Tyr is far less conserved: it was drastically shortened after the separation of Archaea and Eukarya from Eubacteria, and it is also truncated in animal mitochondria. The high degree of phylogenetic divergence in the length of tRNA variable arms, which are recognized by both class I and class II aminoacyl-tRNA synthetases, makes type 2 tRNA recognition an ideal system with which to study how tRNA discrimination may have evolved in tandem with the evolution of other components of the translation machinery.

Comments

This article was originally published in Nucleic Acids Research, volume 27, in 1999. https://doi.org/10.1093/nar/27.3.721

Recommended Citation

Lenhard, B., Orellana, O., Ibba, M. and Weygand-Durasevic, I. (1999) tRNA recognition and evolution of determinants in seryl-tRNA synthesis. Nucleic Acids Res. 27, 721-729. https://doi.org/10.1093/nar/27.3.721

Copyright

Oxford University Press