Oxidation of Phenylalanyl-tRNA Synthetase Positively Regulates Translational Quality Control

Authors

Rebecca E. Steiner, The Ohio State University
Amanda M. Kyle, The Ohio State University
Michael Ibba, Chapman UniversityFollow

Document Type

Article

Publication Date

5-14-2019

Abstract

Regulation of translational quality control during adverse growth conditions is critical to maintain cellular homeostasis. Translational quality control is maintained by proofreading by the aminoacyl-tRNA synthetases (aaRS), which ensure that cognate aminoacyl-tRNAs are provided to the ribosome for protein synthesis. Our findings now show that under oxidative stress a global conformational change in the phenylalanyl-tRNA synthetase positively regulates quality control by increasing the rate of proofreading. These results demonstrate that the translational machinery is able to rapidly and positively respond to environmental challenges to maintain the accuracy of protein synthesis.

Comments

This article was originally published in Proceedings of the National Academy of Sciences of the United States of America, volume 116, in 2019. https://doi.org/10.1073/pnas.1901634116

Recommended Citation

Steiner, R.E., Kyle, A.M. and Ibba, M. (2019) Oxidation of phenylalanyl-tRNA synthetase positively regulates translational quality control. Proc. Natl. Acad. Sci. USA. 116, 10058-10063. https://doi.org/10.1073/pnas.1901634116

Copyright

National Academy of Sciences