Genetic Code: Introducing Pyrrolysine
Monomethylamine methyltransferase of the archaebacterium Methanosarcina barkeri contains a novel amino acid, pyrrolysine, encoded by the termination codon UAG. Initial studies suggest that pyrrolysine may be co-translationally inserted during protein synthesis, probably by a mechanism analogous to that operating during selenocysteine incorporation.
Ibba, M. and Söll, D. (2002) Genetic code: introducing pyrrolysine. Curr. Biol. 12, R464-R466. https://doi.org/10.1016/S0960-9822(02)00947-8
This article was originally published in Current Biology, volume 12, in 2002. https://doi.org/10.1016/S0960-9822(02)00947-8