Document Type
Article
Publication Date
6-14-2018
Abstract
We demonstrate the utility of microgel core/shell structures conjugated to fibrin-specific peptides as fibrinolytic agents. Poly(N-isopropylmethacrylamide) (pNIPMAm) based microgels conjugated to the peptide GPRPFPAC (GPRP) were observed to bring about fibrin clot erosion, merely through exploitation of the dynamic nature of the clots. These results suggest the potential utility of peptide–microgel hybrids in clot disruption and clotting modulation.
Recommended Citation
P. Kodlekere and A. Lyon, Biomater. Sci., 2018, DOI: 10.1039/C8BM00119G.
Copyright
Royal Society of Chemistry
Included in
Amino Acids, Peptides, and Proteins Commons, Medicinal-Pharmaceutical Chemistry Commons, Other Chemicals and Drugs Commons, Other Chemistry Commons, Pharmaceutical Preparations Commons, Polymer Chemistry Commons
Comments
This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Biomaterials Science in 2018 following peer review. The definitive publisher-authenticated version is available online at DOI: 10.1039/C8BM00119G.