Document Type
Article
Publication Date
7-18-2017
Abstract
Menthol belongs to monoterpene class of a structurally diverse group of phytochemicals found in plant-derived essential oils. Menthol is widely used in pharmaceuticals, confectionary, oral hygiene products, pesticides, cosmetics, and as a flavoring agent. In addition, menthol is known to have antioxidant, anti-inflammatory, and analgesic effects. Recently, there has been renewed awareness in comprehending the biological and pharmacological effects of menthol. TRP channels have been demonstrated to mediate the cooling actions ofmenthol. There has been new evidence demonstrating thatmenthol can significantly influence the functional characteristics of a number of different kinds of ligand and voltage-gated ion channels, indicating that at least some of the biological and pharmacological effects of menthol can be mediated by alterations in cellular excitability. In this article, we examine the results of earlier studies on the actions of menthol with voltage and ligand-gated ion channels.
Recommended Citation
Oz M, El Nebrisi EG, Yang K-HS, Howarth FC and Al Kury LT (2017) Cellular and Molecular Targets of Menthol Actions. Front. Pharmacol. 8:472. doi: 10.3389/fphar.2017.00472
Peer Reviewed
1
Copyright
The authors
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Included in
Biochemistry Commons, Biological Factors Commons, Biology Commons, Botany Commons, Medicinal-Pharmaceutical Chemistry Commons, Organic Chemicals Commons, Organic Chemistry Commons, Other Chemicals and Drugs Commons, Other Chemistry Commons, Other Plant Sciences Commons, Pharmaceutical Preparations Commons, Pharmaceutics and Drug Design Commons, Plant Biology Commons
Comments
This article was originally published in Frontiers in Pharmacology, volume 8, in 2017. DOI:10.3389/fphar.2017.00472