Document Type

Article

Publication Date

2003

Abstract

An imbalance between excitation and inhibition can play an important role in the generation of epileptiform activity. Experimental evidence indicates that alterations of either synaptic activity or intrinsic membrane properties may contribute to this imbalance. The slow Ca2+ - activated K+ currents (sIAHP) limit neuronal firing rate and excitability and are therefore of great interest for their potential role in epileptogenesis. The sIAHP is found in both excitatory and inhibitory neurons, and its effect on these neurons can influence the network behavior. Simulations show that the increased excitability caused by reduction of inhibition by the sIAHP for inhibitory interneuron generates recurrent bursting activity.

Comments

This is a pre-copy-editing, author-produced PDF of an article accepted for publication in the proceedings for the Computational Neuroscience Meeting in 2003.

Peer Reviewed

1

Copyright

TNB

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