Document Type
Article
Publication Date
9-5-2025
Abstract
BACKGROUND
Blood pressure (BP) is not steady. It varies over intervals from months to consecutive cardiac cycles, and this variation contains meaningful information beyond mean BP. Variability over multiple clinic visits (VVV-BP) and during 24-h ambulatory monitoring (ABPV) is positively related to risk of stroke and coronary artery disease and negatively associated with cognitive performance. Beat-to-beat BP variation, often quantified as low frequency variability (0.04–0.15 Hz, LF-BPV), is less well-studied. Here, we examine the relationship between LF-BPV and cognitive outcomes in 1953 participants from the Midlife in the US study. METHODS
Participants completed the Brief Test of Adult Cognition by Telephone from which we derived episodic memory (EMF) and executive function (EFF) factors and a composite index. With participants in the seated position, the continuous BP signal was recorded noninvasively with a Finometer. The resultant time series was submitted to Fourier-based spectral analysis to compute LF-BPV. Linear regression models estimated the associations with cognitive indices. RESULTS
Systolic (LF-SBPV) and diastolic (LF-DBPV) were positively associated with EFF (b = 0.073 ± 0.033, P = 0.02), EMF (b = 0.079 ± 0.036, P = 0.04), and the composite index (b = 0.101 ± 0.035, P = 0.004) after adjustment for age, sex, education, and income. Findings were similar for LF-DBPV. CONCLUSIONS
This positive association is consistent with evidence demonstrating that LF blood pressure variability contributes to increased delivery of oxygenated blood to the brain and clearance of metabolic and cellular waste via the brain’s glymphatic system and intramural periarterial drainage pathway, both of which contribute to superior cognitive performance.
Recommended Citation
Joshua Sweigert, Tara Gruenewald, Margie Lachman, Teresa Seeman, Maxine Weinstein, Tse-Hwei Choo, Martina Pavlicova, Ramakrishna Mukkamala, Richard P Sloan, Dynamical Regulation of Blood Pressure and Cognitive Function, American Journal of Hypertension, 2025;, hpaf165, https://doi.org/10.1093/ajh/hpaf165
Copyright
Oxford University Press
Included in
Cardiovascular Diseases Commons, Cognition and Perception Commons, Cognitive Psychology Commons, Psychological Phenomena and Processes Commons
Comments
This is a pre-copy-editing, author-produced PDF of an article accepted for publication in American Journal of Hypertension in 2025 following peer review. The definitive publisher-authenticated version is available online at https://doi.org/10.1093/ajh/hpaf165