Document Type
Article
Publication Date
2-20-2016
Abstract
Study Objective
Midazolam has been found to have beneficial effects on anxiety in children in the preoperative setting. Prior studies have examined various postoperative behaviors of children, but little research has examined the effects of preoperative use of midazolam with postoperative sleep. The purpose of this investigation was to compare postoperative sleep in children as a function of preoperative sedative medication use.
Design
This study was a 2-group randomized controlled trial.
Setting
Participants were recruited from Yale-New Haven Children's Hospital.
Patients
Participants included a convenience sample of 70 children between the ages of 3 to 12 years undergoing ambulatory tonsillectomy and adenoidectomy.
Interventions
Children were randomly assigned to 1 of 2 groups: a control group who received preoperative acetaminophen only (n = 32) and an experimental group who received both acetaminophen and midazolam preoperatively (n = 38).
Measurements
Parents completed measures of postoperative behavioral recovery and a subset of children wore actigraphs to examine objective sleep data.
Main Results
Children who received midazolam experienced similar sleep changes compared to children in the control group. The actigraph data revealed that children who received midazolam were awake significantly less during the night compared to the control group (P= .01).
Conclusion
Children who received midazolam before surgery had similar postoperative sleep changes compared to children who did not receive midazolam. Further understanding of the postoperative behavioral effects of midazolam on children will help guide healthcare providers in their practice.
Recommended Citation
Min, C. B., Kain, Z. N., Stevenson, R. S., Jenkins, B. N., & Fortier, M. A. (2016). A randomized trial examining preoperative sedative medication and post-operative sleep in children. Journal of Clinical Anesthesia, 30, 15-20. doi: 10.1016/j.jclinane.2015.11.011
Copyright
Elsevier
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Comments
NOTICE: this is the author’s version of a work that was accepted for publication in Journal of Clinical Anesthesia. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Clinical Anesthesia, volume 30, in 2016. DOI: 10.1016/j.jclinane.2015.11.011
The Creative Commons license below applies only to this version of the article.