Baraphenazines A–G, Divergent Fused Phenazine-Based Metabolites from a Himalayan Streptomyces
The structures and bioactivities of three unprecedented fused 5-hydroxyquinoxaline/alpha-keto acid amino acid metabolites (baraphenazines A–C, 1–3), two unique diastaphenazine-type metabolites (baraphenazines D and E, 4 and 5) and two new phenazinolin-type (baraphenazines F and G, 6 and 7) metabolites from the Himalayan isolate Streptomyces sp. PU-10A are reported. This study highlights the first reported bacterial strain capable of producing diastaphenazine-type, phenazinolin-type, and izumiphenazine A-type metabolites and presents a unique opportunity for the future biosynthetic interrogation of late-stage phenazine-based metabolite maturation.
Wang X, Abbas M, Zhang Y, et al. Baraphenazines A-G, Divergent Fused Phenazine-Based Metabolites from a Himalayan Streptomyces. J Nat Prod. 2019;82(6):1686-1693. https://doi.org/10.1021/acs.jnatprod.9b00289
American Chemical Society and American Society of Pharmacognosy