Baraphenazines A–G, Divergent Fused Phenazine-Based Metabolites from a Himalayan Streptomyces

Authors

Xiachang Wang, Nanjing University of Chinese Medicine
Muhammad Abbas, University of the Punjab
Yinan Zhang, anjing University of Chinese Medicine
Sherif I. Elshahawi, Chapman UniversityFollow
Larissa V. Ponomareva, University of Kentucky
Zheng Cui, University of Kentucky
Steven G. Van Lanen, University of Kentucky
Imran Sajid, University of the Punjab
S. Randal Voss, University of Kentucky
Khaled A. Shaaban, University of Kentucky
Jon S. Thorson, University of Kentucky

Document Type

Article

Publication Date

5-22-2019

Abstract

The structures and bioactivities of three unprecedented fused 5-hydroxyquinoxaline/alpha-keto acid amino acid metabolites (baraphenazines A–C, 1–3), two unique diastaphenazine-type metabolites (baraphenazines D and E, 4 and 5) and two new phenazinolin-type (baraphenazines F and G, 6 and 7) metabolites from the Himalayan isolate Streptomyces sp. PU-10A are reported. This study highlights the first reported bacterial strain capable of producing diastaphenazine-type, phenazinolin-type, and izumiphenazine A-type metabolites and presents a unique opportunity for the future biosynthetic interrogation of late-stage phenazine-based metabolite maturation.

Comments

This article was originally published in Journal of Natural Products, volume 82, issue 6, in 2019. https://doi.org/10.1021/acs.jnatprod.9b00289

Recommended Citation

Wang X, Abbas M, Zhang Y, et al. Baraphenazines A-G, Divergent Fused Phenazine-Based Metabolites from a Himalayan Streptomyces. J Nat Prod. 2019;82(6):1686-1693. https://doi.org/10.1021/acs.jnatprod.9b00289

Copyright

American Chemical Society and American Society of Pharmacognosy