Document Type
Article
Publication Date
12-4-2020
Abstract
The incidence of Kaposi’s sarcoma-associated herpesvirus (KSHV)-associated Kaposi Sarcoma has declined precipitously in the present era of effective HIV treatment. However, KSHV-associated lymphoproliferative disorders although rare, have not seen a similar decline. Lymphoma is now a leading cause of death in people living with HIV (PLWH), indicating that the immune reconstitution provided by antiretroviral therapy is not sufficient to fully correct the lymphomagenic immune dysregulation perpetrated by HIV infection. As such, novel insights into the mechanisms of KSHV-mediated pathogenesis in the immune compartment are urgently needed in order to develop novel therapeutics aimed at prevention and treatment of KSHV-associated lymphoproliferations. In this review, we will discuss our current understanding of KSHV molecular virology in the lymphocyte compartment, concentrating on studies which explore mechanisms unique to infection in B lymphocytes.
Recommended Citation
Aalam F, Totonchy J. Molecular virology of KSHV in the lymphocyte compartment—Insights from patient samples and de novo infection models. Front Cell Infect Microbiol. 2020;10:607663. https://doi.org/10.3389/fcimb.2020.607663
Copyright
The authors
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Included in
Immune System Diseases Commons, Other Pharmacy and Pharmaceutical Sciences Commons, Virus Diseases Commons
Comments
This article was originally published in Frontiers in Cellular and Infection Microbiology, volume 10, in 2020. https://doi.org/10.3389/fcimb.2020.607663