Ruthmycin, a New Tetracyclic Polyketide from Streptomyces sp. RM-4-15
The isolation and structural elucidation of a new tetracyclic polyketide (ruthmycin) from Streptomyces sp. RM-4-15, a bacteria isolated near thermal vents from the Ruth Mullins underground coal mine fire in eastern Kentucky, is reported. In comparison to the well-established frenolicin core scaffold, ruthmycin possesses an unprecedented signature C3 bridge and corresponding fused six member ring. Preliminary in vitro antibacterial, anticancer and antifungal assays revealed ruthmycin to display moderate antifungal activity.
Wang X, Elshahawi SI, Shaaban KA, et al. Ruthmycin, a new tetracyclic polyketide from Streptomyces sp. RM-4-15. Org. Lett. 2014;16(2):456-459.https://doi.org/10.1021/ol4033418
American Chemical Society