Mullinamides A and B, New Cyclopeptides Produced by the Ruth Mullins Coal Mine Fire Isolate Streptomyces sp. RM-27-46

Authors

Xiachang Wang, University of Kentucky
Khaled A. Shaaban, University of Kentucky
Sherif Elshahawi, Chapman UniversityFollow
Larissa V. Ponomareva, University of Kentucky
Manjula Sunkara, University of Kentucky
Gregory C. Copley, University of Kentucky
James C. Hower, University of Kentucky
Andrew J. Morris, University of Kentucky
Madan K. Kharel, University of Kentucky
Jon S. Thorson, University of Kentucky

Document Type

Article

Publication Date

4-9-2014

Abstract

Two new cyclopeptides, mullinamides A [cyclo-(-L-Gly-L-Glu-L-Val-L-Ile-L-Pro-)] and B [cyclo-(-L-Glu-L-Met-L-Pro-)] were isolated from the crude extract of terrestrial Streptomyces sp. RM-27-46 along with the three known cyclopeptides surugamide A [cyclo-(-L-Ile-D-Ile-L-Lys-L-Ile-D-Phe-D-Leu-L-Ile-D-Ala-)], cyclo-(-L-Pro-L-Phe-) and cyclo-(-L-Pro-L-Leu-). The structures of the new compounds were elucidated by the cumulative analyses of NMR spectroscopy and HRMS. Although mullinamides A and B displayed no appreciable antimicrobial/fungal activity or cytotoxicity, this study highlights the first reported antibacterial activity of surugamide A.

Comments

This article was originally published in Journal of Antibiotics, volume 67, issue 8, in 2014. https://doi.org/10.1038/ja.2014.37

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Recommended Citation

Wang X, Shaaban KA, Elshahawi SI, et al. Mullinamides A and B, new cyclopeptides produced by the Ruth Mullins coal mine fire isolate Streptomyces sp. RM-27-46. J. Antibiot. 2014;67(8):571-575. https://doi.org/10.1038/ja.2014.37

Copyright

Springer