ls There Any Risk of a Withdrawal Syndrome Associated with Abrupt Discontinuation of Selective Serotonin Reuptake Inhibitors?

Authors

Rene A. Endow, University of Southern California
Mary Gutierrez, Chapman UniversityFollow
Michael Z. Wincor, University of Southern California

Document Type

Article

Publication Date

1996

Abstract

"With the availability of the newer selective serotonin reuptake inhibitors (SSRis), concern over a 'cholinergie rebound' seemed unnecessary since these agents demonstrate little or no anticholinergic activity. However, a review of the literature indicates that there may be other withdrawal symptoms associated with discontinuation of the SSRis. The time course and, perhaps to a lesser extent, the frequency of these symptoms appear to be correlated with the elimination half-lives of the agents."

Comments

This article was originally published in California Pharmacist, volume 43, in 1996.

Recommended Citation

Endow RA, Gutierrez MA, Wincor MZ. Is there any risk of a withdrawal syndrome associated with abrupt discontinuation of selective serotonin reuptake inhibitors? Calif Pharmacist. 1996;43:26-27.

Copyright

California Pharmacists Association