"CXCR7 was recently characterized as an alternative receptor for the chemokine CXCL12/SDF-1, previously thought to bind and signal exclusively through CXCR4.We recently identified CXCR7 as a key cellular factor in the endothelial cell (EC) dysfunction associated with KSHV infection. CXCL12 signaling is critically associated with tumor growth, angiogenesis and metastasis in several diverse tumors and is one of the most studied chemokine/chemokine receptor interactions in cancer systems. The tumorigenic activity of the CXCL12 signaling axis offers an attractive target for therapeutic intervention in multiple cancers including Kaposi’s Sarcoma (KS). However, most of the research to date was based on the assumption that CXCR4 was the sole CXCL12 receptor, and thus focused on the development of CXCR4-targeted treatments."
Vomaske J, Clepper L, Douglas J, Pantanowitz L, Fruh K, Moses AV. KSHV infection of endothelial cells manipulates CXCR7-mediated signaling: Implications for Kaposi’s Sarcoma progression and intervention. Infect Agent Cancer. 2012;7(S1):O6. doi: 10.1186/1750-9378-7-S1-O6
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