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A palladium-catalyzed intramolecular dehydrogenative coupling reaction was developed for the synthesis of fused imidazo[1,2-a]pyrimidines and pyrazolo[1,5-a]- pyrimidines. The developed protocol provides a practical approach for the synthesis of biologically important substituted pyrimidines from easily available substrates, with a broad substrate scope under mild reaction conditions.


This article was originally published in ACS Omega, volume 2, in 2017. DOI: 10.1021/acsomega.6b00417

It is published under an ACS Author Choice License.


American Chemical Society



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