The Role of Peptides in Combatting HIV Infection: Applications and Insights

Authors

Naiera M. Helmy, Chapman UniversityFollow
Keykavous Parang, Chapman UniversityFollow

Document Type

Article

Publication Date

10-19-2024

Abstract

Peptide-based inhibitors represent a promising approach for the treatment of HIV-1, offering a range of potential advantages, including specificity, low toxicity, and the ability to target various stages of the viral lifecycle. This review outlines the current state of research on peptide-based anti-HIV therapies, highlighting key advancements and identifying future research directions. Over the past few years, there has been significant progress in developing synthetic peptide-based drugs that target various stages of the viral life cycle, including entry and replication. These approaches aim to create effective anti-HIV therapies. Additionally, peptides have proven valuable in the development of anti-HIV vaccines. In the quest for effective HIV vaccines, discovering potent antigens and designing suitable vaccine strategies are crucial for overcoming challenges such as low immunogenicity, safety concerns, and increased viral load. Innovative strategies for vaccine development through peptide research are, therefore, a key focus area for achieving effective HIV prevention. This review aims to explore the strategies for designing peptides with anti-HIV activity and to highlight their role in advancing both therapeutic and preventive measures against HIV.

Comments

This article was originally published in Molecules, volume 29, issue 20, in 2024. https://doi.org/10.3390/molecules29204951

Recommended Citation

Helmy, N.M.; Parang, K. The Role of Peptides in Combatting HIV Infection: Applications and Insights. Molecules 2024, 29, 4951. https://doi.org/10.3390/molecules29204951

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The authors

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.