Document Type
Article
Publication Date
1-31-2024
Abstract
Poor oral health is associated with cardiovascular disease and dementia. Potential pathways include sepsis from oral bacteria, systemic inflammation, and nutritional deficiencies. However, in post-industrialized populations, links between oral health and chronic disease may be confounded because the lower socioeconomic exposome (poor diet, pollution, low physical activity) often entails insufficient dental care. We assessed tooth loss, caries, and damaged teeth, in relation to cardiovascular and brain aging among the Tsimane, a subsistence population living a relatively traditional forager-horticulturalist lifestyle with poor dental health, but minimal cardiovascular disease and dementia. Dental health was assessed by a physician in 739 participants aged 40-92 years with cardiac and brain health measured by chest computed tomography (CT) (n=728) and brain CT (n=605). A subset of 356 individuals aged 60+ were also assessed for dementia and mild cognitive impairment (n=33 impaired). Tooth loss was highly prevalent, with 2.2 teeth lost per decade and a 2-fold greater loss in women. The number of teeth with exposed pulp was associated with higher inflammation, as measured by cytokine levels and white blood cell counts, and lower body mass index. Coronary artery calcium and thoracic aortic calcium were not associated with tooth loss or damaged teeth. However, aortic valve calcification and brain tissue loss were higher in those that had more teeth with exposed pulp. Overall, these results suggest that dental health is associated with indicators of chronic diseases in the absence of typical confounds, even in a population with low cardiovascular and dementia risk factors.
Recommended Citation
Benjamin C Trumble, Matthew Schwartz, Andrew T Ozga, Gary T Schwartz, Christopher M Stojanowski, Carrie L Jenkins, Thomas S Kraft, Angela R Garcia, Daniel K Cummings, Paul L Hooper, Daniel Eid Rodriguez, Kenneth Buetow, Bret Beheim, Andrei Irimia, Gregory S Thomas, Randall C Thompson, HORUS Team, Margaret Gatz, Jonathan Stieglitz, Caleb E Finch, Michael Gurven, Hillard Kaplan, Poor oral health is associated with inflammation, aortic valve calcification, and brain volume among forager-farmers, The Journals of Gerontology: Series A, Volume 79, Issue 5, May 2024, glae013, https://doi.org/10.1093/gerona/glae013
Peer Reviewed
1
Copyright
Oxford University Press
Included in
Biological and Physical Anthropology Commons, Economic Theory Commons, Other Economics Commons
Comments
This is a pre-copy-editing, author-produced PDF of an article accepted for publication in The Journals of Gerontology: Series A, volume 79, issue 5, in 2024 following peer review. The definitive publisher-authenticated version is available online at https://doi.org/10.1093/gerona/glae013.