Document Type
Article
Publication Date
8-18-2010
Abstract
Objectives—Little is known about blood cholesterol (blood-C) levels under conditions of infection and limited diet. This study examines blood-C and markers of infection and inflammation in the Tsimane of the Bolivian Amazon, indigenous forager farmers living in conditions that model preindustrial European populations by their short life expectancy, high load of infections and inflammation, and limited diets.
Methods—We use multivariate models to determine the relationships between lipid levels and markers of infection and inflammation. Adult Tsimane (N = 418, age 20–84) were characterized for blood lipids, cells, and inflammatory markers in relation to individual loads of parasites and village region.
Results—Most of the Tsimane (60%) carried at least one parasite species, averaging 1.3 species per person. Serum high-density lipoprotein cholesterol (HDL-C), total cholesterol (total-C), and low-density lipoprotein cholesterol (LDL-C) were below the U.S. norms and varied inversely with markers of infection and inflammation: C-reactive protein (CRP), interleukin-6 (IL-6), erythrocyte sedimentation rate (ESR), immunoglobulin (Ig) E and eosinophil count. Although no relationship of parasite load to blood-C was found, there was an association between anemia and parasite prevalence.
Conclusions—We conclude that the highly infected environment of the Tsimane is related to low levels of blood total-C, HDL-C, and LDL-C. This may suggest a potential reason why arterial disease is largely absent in the Tsimane.
Recommended Citation
Vasunilashorn, S., Crimmins, E. M., Kim, J. K., Winking, J., Gurven, M., Kaplan, H., & Finch, C. E. (2010). Blood lipids, infection, and inflammatory markers in the Tsimane of Bolivia. American Journal of Human Biology, 22(6), 731-740. https://doi.org/10.1002/ajhb.21074
Peer Reviewed
1
Copyright
Wiley
Included in
Biological and Physical Anthropology Commons, Economic Theory Commons, Ethnic Studies Commons, Latin American Studies Commons, Other Anthropology Commons, Other Economics Commons, Social and Cultural Anthropology Commons
Comments
This is the accepted version of the following article:
Vasunilashorn, S., Crimmins, E. M., Kim, J. K., Winking, J., Gurven, M., Kaplan, H., & Finch, C. E. (2010). Blood lipids, infection, and inflammatory markers in the Tsimane of Bolivia. American Journal of Human Biology, 22(6), 731-740.
which has been published in final form at https://doi.org/10.1002/ajhb.21074. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.