Document Type
Article
Publication Date
5-16-2011
Abstract
The Tsimane of lowland Bolivia are an indigenous forager-farmer population living under conditions resembling pre-industrial European populations, with high infectious morbidity, high infection and inflammation, and shortened life expectancy. Analysis of 917 persons ages 5 to 60+ showed that allele frequencies of 9 SNPs examined in the apolipoprotein E (apoE), C-reactive protein (CRP), and interleukin-6 (IL-6) genes differed from some European, African, and north Asian-derived populations. The apoE2 allele was absent, whereas four SNPs related to CRP and IL-6 were monomorphic: CRP (rs1800947, rs3093061, and rs3093062) and IL-6 (rs1800795). No significant differences in apoE, CRP, and IL-6 variants across age were found CRP levels were higher in carriers of two CRP proinflammatory SNPs, whereas they were lower in carriers of apoE4. Taken together, the evidence for (1) different allele frequencies between the Tsimane and other populations and (2) the correlations of CRP and apoE alleles with blood CRP may suggest that these variants are under selection in response to a high infection environment.
Recommended Citation
Vasunilashorn, S., Finch, C. E., Crimmins, E. M., et al. (2011). Inflammatory gene variants in the Tsimane, an indigenous Bolivian population with a high infectious load. Biodemography and Social Biology, 57(1), 33-52. https://doi.org/10.1080/19485565.2011.564475
Peer Reviewed
1
Copyright
Taylor & Francis
Included in
Biological and Physical Anthropology Commons, Economic Theory Commons, Ethnic Studies Commons, Latin American Studies Commons, Other Anthropology Commons, Other Economics Commons, Social and Cultural Anthropology Commons
Comments
This is an Accepted Manuscript of an article published in Biodemography and Social Biology, volume 57, issue 1, in 2011, available online at https://doi.org/10.1080/19485565.2011.564475. It may differ slightly from the final version of record.