Nanoscale Opportunities in Extracellular Matrix Mimicry

Authors

L. Andrew Lyon, Chapman UniversityFollow
Abbygail Caine, Chapman University
Elif Narbay, Chapman UniversityFollow
E. Daniel Cárdenas-Vásquez, Chapman University

Document Type

Article

Publication Date

2-27-2026

Abstract

We present an overview of the composition, function, energetics, and dynamics of extracellular matrix and its relation to nanoscale structures and phenomena. These concepts are then related to the development of synthetic and biosynthetic materials that aim to mimic the extracellular matrix for regenerative medicine and tissue engineering technologies. Notable successes and advancements towards the goal of biomimicry are outlined, while remaining challenges and knowledge gaps towards that goal are highlighted. Finally, we frame the remaining challenges in the field in terms of nanoscience-related research opportunities that if solved, might prove to be transformative steps forward in the discipline.

Comments

This article was originally published in Nanoscale Horizons, volume number, issue number, in year. https://doi.org/

Recommended Citation

L. A. Lyon, A. Caine, E. Narbay, and E. D. Cárdenas-Vásquez, Nanoscale Horiz., 2026. https://doi.org/10.1039/D5NH00735F

Copyright

The authors

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial 3.0 License