Small interfering RNAs have been an emerging medical treatment for molecular based diseases as they are capable of gene-specific knockdown. Appropriate and efficient delivery remains one of the biggest challenges in the development of siRNA as an anti-cancer treatment. Nanoparticles containing siRNA were characterized and the efficacy of various peptides in the transfection of the nanoparticles were tested. A gene silencing assay was developed in order to determine the effect of siRNA therapeutics on gene functionality in breast cancer cells.
Pong, Sydney; Shah, Samit; and Gupta, Vivek, "Engineered PLGA Nanoparticles for Delivery of siRNA in MCF-7 Breast Cancer Cells" (2014). Student Scholar Symposium Abstracts and Posters. 39.