Engineered PLGA Nanoparticles for Delivery of siRNA in MCF-7 Breast Cancer Cells

Authors

Sydney Pong, Chapman UniversityFollow
Samit Shah, Keck Graduate InstituteFollow
Vivek Gupta, Keck Graduate InstituteFollow

Document Type

Poster

Publication Date

12-10-2014

Faculty Advisor(s)

Elaine Schwartz

Abstract

Small interfering RNAs have been an emerging medical treatment for molecular based diseases as they are capable of gene-specific knockdown. Appropriate and efficient delivery remains one of the biggest challenges in the development of siRNA as an anti-cancer treatment. Nanoparticles containing siRNA were characterized and the efficacy of various peptides in the transfection of the nanoparticles were tested. A gene silencing assay was developed in order to determine the effect of siRNA therapeutics on gene functionality in breast cancer cells.

Comments

Presented at the Fall 2014 Undergraduate Student Research Day at Chapman University.

Recommended Citation

Pong, Sydney; Shah, Samit; and Gupta, Vivek, "Engineered PLGA Nanoparticles for Delivery of siRNA in MCF-7 Breast Cancer Cells" (2014). Student Scholar Symposium Abstracts and Posters. 39.
https://digitalcommons.chapman.edu/cusrd_abstracts/39