Document Type
Article
Publication Date
5-31-2022
Abstract
Chronic aphasia, a devastating impairment of language, affects up to a third of stroke survivors. Speech and language therapy has consistently been shown to improve language function in prior clinical trials, but few clinicially applicable predictors of individual therapy response have been identified to date. Consequently, clinicians struggle substantially with prognostication in the clinical management of aphasia. A rising prevalence of aphasia, in particular in younger populations, has emphasized the increasing demand for a personalized approach to aphasia therapy, that is, therapy aimed at maximizing language recovery of each individual with reference to evidence-based clinical recommendations. In this narrative review, we discuss the current state of the literature with respect to commonly studied predictors of therapy response in aphasia. In particular, we focus our discussion on biographical, neuropsychological, and neurobiological predictors, and emphasize limitations of the literature, summarize consistent findings, and consider how the research field can better support the development of personalized aphasia therapy. In conclusion, a review of the literature indicates that future research efforts should aim to recruit larger samples of people with aphasia, including by establishing multisite aphasia research centers.
Recommended Citation
Kristinsson, S., Den Ouden, D.B., Rorden, C., Newman-Norlund, R., Neils-Strunjas, J., and Fridriksson, J. (2022) Predictors of Therapy Response in Chronic Aphasia: Building a Foundation for Personalized Aphasia Therapy. Journal of Stroke, 24(2), 189-206. https://doi.org/10.5853/jos.2022.01102
Peer Reviewed
1
Copyright
Korean Stroke Society
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
Comments
This article was originally published in Journal of Stroke, volume 24, issue 2, in 2022. https://doi.org/10.5853/jos.2022.01102