Document Type
Article
Publication Date
10-1-2024
Abstract
Understanding the neurobiology of semantic knowledge is a major goal of cognitive neuroscience. Taxonomic and thematic semantic knowledge are represented differently within the brain's conceptual networks, but the specific neural mechanisms remain unclear. Some neurobiological models propose that the anterior temporal lobe is an important hub for taxonomic knowledge, whereas the TPJ is especially involved in the representation of thematic knowledge. However, recent studies have provided divergent evidence. In this context, we investigated the neural correlates of taxonomic and thematic confrontation naming errors in 79 people with aphasia. We used three complementary lesion-symptom mapping (LSM) methods to investigate how structure and function in both spared and impaired brain regions relate to taxonomic and thematic naming errors. Voxel-based LSM mapped brain damage, activation-based LSM mapped BOLD signal in surviving tissue, and network-based LSM mapped white matter subnetwork integrity to error type. Voxel- and network-based lesion symptom mapping provided converging evidence that damage/disruption of the left mid-to-anterior temporal lobe was associated with a greater proportion of thematic naming errors. Activation-based lesion symptom mapping revealed that higher BOLD signal in the left anterior temporal lobe during an in-house naming task was associated with a greater proportion of taxonomic errors on the Philadelphia Naming Test administered outside of the scanner. A lower BOLD signal in the bilateral angular gyrus, precuneus, and right inferior frontal cortex was associated with a greater proportion of taxonomic errors. These findings provide novel evidence that damage to the anterior temporal lobe is especially related to thematic naming errors.
Recommended Citation
Riccardi, N., Blackett, D. S., Broadhead, A., den Ouden, D.B., Rorden, C., Fridriksson, J., Bonilha, L., & Desai, R. H. (2024). A Rose by Any Other Name: Mapping Taxonomic and Thematic Naming Errors Poststroke. Journal of Cognitive Neuroscience, 36(10), 2251-2267. https://doi.org/10.1162/jocn_a_02236
Peer Reviewed
1
Copyright
Massachusetts Institute of Technology
Included in
Cognitive Science Commons, Communication Sciences and Disorders Commons, Nervous System Commons, Neurosciences Commons
Comments
This article was originally published in Journal of Cognitive Neuroscience, volume 36, issue 10, in 2024. https://doi.org/10.1162/jocn_a_02236