Document Type
Article
Publication Date
11-18-2021
Abstract
Objectives
Heightened inflammatory state, as measured by circulating C-reactive protein (CRP) levels, can promote inflammation-mediated disease risk. It is important to account for population fluctuation and sex variation in serum CRP concentrations on overall time trends.
Methods
Using the National Health and Nutrition Examination Survey data, we specify linear and algebraic decomposition models separately by sex to identify the drivers of the changing trends in the distribution of CRP values in the population.
Results
We found a nonsignificant overall increase in CRP, but a significant decrease among women and increase among men, over a 10-year period. We then used linear and algebraic decomposition techniques to identify the sources of change in CRP over time, separately for women and men. CRP increased among men mainly because lifestyle/health characteristics worsened over time, and because the size of socioeconomic/demographic groups with higher CRP increased and the size of groups with lower CRP decreased. The downward shift in CRP among women occurred because the typical woman across all cohorts had lower CRP levels.
Conclusions
We identified two fundamentally different processes of change driving the decline and rise in CRP values among women and men, respectively.
Recommended Citation
Kranjac, A. W., Kranjac, D., & Lounsbury, O. (2021). Deconstructing sex differences in C-reactive protein trends over time. American Journal of Human Biology 34(5): E23705. https://doi.org/10.1002/ajhb.23705
Peer Reviewed
1
Copyright
Wiley
Included in
Amino Acids, Peptides, and Proteins Commons, Gender and Sexuality Commons, Medicine and Health Commons, Other Psychiatry and Psychology Commons, Psychological Phenomena and Processes Commons
Comments
This is the accepted version of the following article:
Kranjac, A. W., Kranjac, D., & Lounsbury, O. (2021). Deconstructing sex differences in C-reactive protein trends over time. American Journal of Human Biology 34(5): E23705. https://doi.org/10.1002/ajhb.23705
which has been published in final form athttps://doi.org/10.1002/ajhb.23705. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.