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Inflammatory responses to implanted biomedical devices elicit a foreign body fibrotic reaction that limits device integration and performance in various biomedical applications. We examined chronic inflammatory responses to microgel conformal coatings consisting of thin films of poly(N-isopropylacrylamide) hydrogel microparticles cross-linked with poly(ethylene glycol) diacrylate deposited on poly(ethylene terephthalate) (PET). Unmodified and microgel-coated PET disks were implanted subcutaneously in rats for 4 weeks and explants were analyzed by histology and immunohistochemistry. Microgel coatings reduced chronic inflammation and resulted in a more mature/organized fibrous capsule. Microgel-coated samples exhibited 22% thinner fibrous capsules that contained 40% fewer cells compared to unmodified PET disks. Furthermore, microgel-coated samples contained significantly higher levels of macrophages (80%) than unmodified PET controls. These results demonstrate that microgel coatings reduce chronic inflammation to implanted biomaterials.


This is the accepted version of the following article:

Bridges, A. W.; Whitmire, R. E.; Singh, N.; Templeman, K. L.; Babensee, J. E.; Lyon, L. A.; Garcia, A. J., Chronic inflammatory responses to microgel-based implant coatings, Journal of Biomedical Materials Research Part A 2010, 94A (1), 252-258.

which has been published in final form at DOI: 10.1002/jbm.a.32669.





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