Document Type

Editorial

Publication Date

11-23-2020

Abstract

"Since the description of the operon model by Jacob and Monod during the late 1950s and early 1960s (Ullmann, 2010), the concept that the reading of genetic information must be a regulated process has been central to our understanding of biology. This is particularly true for microbes, which can adapt to an incredible variety of environments. Based on the research performed since the description of the operon, we have gained a deep understanding of the diverse strategies used by microbes to modulate the transcription of genetic information from DNA to RNA. In contrast, the mechanisms that regulate the translation of messenger RNAs into proteins has received less attention. The technical developments of the last decade now allow us to obtain detailed information on RNA folding (Rouskin et al., 2014; Aw et al., 2016) and modification (Linder et al., 2015; Lorenz et al., 2020) and the speed of translation (Subramaniam et al., 2013; Ingolia, 2014; Dai et al., 2016). This, in turn, allows us to scrutinize the functionality of translation components in vivo, providing unprecedented opportunities to study translation regulation. In this special issue of Frontiers in Genetics, 'Microbial Regulation of Translation,' we have assembled a series of articles that use diverse experimental approaches to study the regulation of translation in microbes."

Comments

This editorial was originally published in Frontiers in Genetics, volume 11, in 2020. https://doi.org/10.3389/fgene.2020.616946

Copyright

The authors

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.