Bridging the Gap between Ribosomal and Non-ribosomal Protein Synthesis

Authors

Hervé Roy, The Ohio State University
Michael Ibba, Chapman UniversityFollow

Document Type

Article

Publication Date

8-17-2010

Abstract

Aminoacyl-tRNA synthetases (aaRSs) are the enzymes normally responsible for the attachment of amino acids (aa) to tRNAs. Numerous paralogous proteins of aaRSs have been identified in a wide range of organisms, but the functions of most of these aaRS-like proteins are yet to be determined. In PNAS, the study by Mocibob et al. (1) identifies a paralog of seryl-tRNA synthetase that does not aminoacylate a tRNA, but instead, aminoacylates an aa carrier protein. This exciting discovery provides an unforeseen function for the aaRS architecture and also uncovers a possible evolutionary link between ribosome-catalyzed translation and nonribosomal peptide synthesis.

Comments

This article was originally published in Proceedings of the National Academy of Sciences of the United States of America, volume 107, in 2010. https://doi.org/10.1073/pnas.1009939107

Recommended Citation

Roy, H. and Ibba, M. (2010) Bridging the gap between ribosomal and non-ribosomal protein synthesis. Proc. Natl. Acad. Sci. USA 107, 14517-14518. https://doi.org/10.1073/pnas.1009939107

Copyright

The authors